[The first tuberculosis cure with chemotherapy: a lupus patient in Hornheide]. / Die erste Tuberkuloseheilung mit Chemotherapie: Eine Lupuskranke in Hornheide.

Karl Wilhelm Kalkoff (1909-1981) describes in his unpublished memoirs the first cure of a female patient suffering from a severe form of tuberculosis cutis of the lupus vulgaris type. The drug used in this case was TBI/698 developed by Bayer Leverkusen, which was later named Conteben. This was the first chemotherapeutic cure of tuberculosis.

[Etiology of perioral dermatitis]. / Zur Pathogenese der perioralen Dermatitis

The studies of Röckl und Schubert supported the theory that fusobacteria are often found in perioral dermatitis. When we characterize perioral dermatitis as fusobacteriosis, we do not have any doubt that fluorinated corticosteroids represent a very important pathogenetic factor. Corticoids enable opportune fusobacteria to become pathogenic. In our opinion without these bacteria the beginning of the perioral dermatitis seems impossible. Other supporting causes, which are relevant to sex distribution (oral contraceptives, moisturizing creams) are described.

[Optimal dosage in peroral therapy of acne with vitamin A palmitate]. / Zur optimalen Dosierung einer peroralen Therapie der Akne mit Vitamin-A-Palmitat

Successful oral therapy with vitamin A palmitate in acne vulgaris requires 150,000-200,000 I.U. daily for months. Side-effects were evaluated in 22 patients and in addition in 54 patients receiving 400,000 and 300,000 I.U. respectively for 3-4 weeks (SGPT, GGPT, Quick, electrophoresis, creatinine, bromosulfthaleine excretion). The same tests were done in 32 patients, who had received vitamin A palmitate 150,000-200,000 I.U. daily for at least half a year. Clinical experience and the presented data allow the following conclusions: There is no risk of liver impairement when 150,000-200,000 I.U. are given daily over extended periods. Doses over 300,000 I.U. are accompanied with liver impairement. During long-term treatment y-GT test should be performed regularly. Contraceptive advices are recommended.

[Fumaric acid monoethylester: Effect on DNA-synthesis and preliminary findings in experimental studies in animals (author's transl)]. / Fumarsäuremonoäthylester: Wirkung auf DNA-Synthese und erste tierexperimentelle Befunde

The incorporation of 14C-Thymidin into DNA of cultured human lymphocytes is depressed by added fumaric acid monoethylester (FSME) depending on the dosage of FSME. The decreased radioactivity in DNA as measured by scintillation counting is paralleled by a concomitant decrease in the labelling index in autoradiograms. Decreasing radioactivity is therefore due to a lower number of DNA synthesizing cells. No selective inhibition of proliferation during one of the cell cycle phases was observed. Especially a G2-block known from other cytostaties is absent. A mean dosis of 6.88 mg FSME per g body weight administered intraperitoneally is lethal to mice. The animal die from diffuse necroses of heart muscle cell. Alterations of other organs are less prominent. At lower doses of FSME the morphology of the organs investigated is altered to a smaller degree.

[The effect of fumaric acid monoethylester on the synthesis of nucleic acids and proteins of PHA-stimulated human lymphocytes (author's transl)]. / Der Einfluss von Fumarsäuremonoäthylester auf die Nucleinsäure- und Proteinsynthese PHA-stimulierter menschlicher Lymphocyten

Fumaric acid monoethylester (FAME) inhibits the incorporation of 14C-Thymidin, 14C-Uridin, 14C-Alanin and 14C-Leucin into acid-insoluble biopolymers of cultivated PHA-stimulated human lymphocytes. At high concentrations of FAME (500 mug/ml culture medium) the inhibition of nucleic acid synthesis is 6 times higher on the average than the inhibition of protein synthesis. However, the application of the cis-isomer, maleic acid monoethylester (MAME), results in an increase of the incorporation rate of the labelled precursors into the RNA and DNA. This is 3.5--9.3 times higher than after application of FAME. The results demonstrate the specific inhibition by FAME. The rate of labelling of nucleic acids is decreased above 10 mug FAME/ml culture medium and in the case of MAME above 50 mug/ml medium. As an explanation of the specific action of FAME its influence on the enzymes of the nucleic acid synthesis, the citric acid cycle or a faulty synthesis of enzymes are discussed.