Implementation science in low-resource settings: using the interactive systems framework to improve hand hygiene in a tertiary hospital in Ghana.

QUALITY ISSUE: Low-resource clinical settings often face obstacles that challenge the implementation of recommended evidence-based practices (EBPs). Implementation science approaches are useful in identifying barriers and developing strategies to address them. INITIAL ASSESSMENT: Ridge Regional Hospital (RRH), a tertiary referral hospital in Accra, Ghana experienced a spike in rates of neonatal sepsis and launched a quality improvement (QI) initiative that identified poor adherence to hand hygiene in the neonatal intensive care unit as a potential source of infections. CHOICE OF SOLUTION: A multi-modal change package of World Health Organization-recommended solutions was created to address this issue. IMPLEMENTATION: To ensure that the outputs of the QI effort were adopted within the organization, leaders at RRH and Kybele, Inc. used an implementation science framework called the 'Interactive Systems Framework for Dissemination and Implementation' (ISF) to create a package of locally acceptable implementation strategies. The ISF has never been used before to guide implementation in low-resource settings. EVALUATION: Hand hygiene compliance rose from 67% to 92% overall, including a 36% increase during the night shifts-a group of healthcare workers with typically very low levels of compliance. LESSONS LEARNED: The drastic improvement in adherence to hand hygiene suggests the potential value of the joint use of QI and implementation science to promote the creation and application of contextually appropriate EBPs in low-resource settings. Our results also suggest that using an implementation framework such as the ISF could rapidly increase the uptake of other evidence-based interventions in low-resource settings.

Global health partnerships: building multi-national collaborations to achieve lasting improvements in maternal and neonatal health.

BACKGROUND: In response to health care challenges worldwide, extensive funding has been channeled to the world's most vulnerable health systems. Funding alone is not sufficient to address the complex issues and challenges plaguing these health systems. To see lasting improvement in maternal and infant health outcomes in the developing world, a global commitment to the sharing of knowledge and resources through international partnerships is critical. But partnerships that merely introduce western medical techniques and protocols to low resource settings, without heeding the local contexts, are misguided and unsustainable. Forming partnerships with mutual respect, shared vision, and collaborative effort is needed to ensure that all parties, irrespective of whether they belong to resource rich or resource poor settings, learn from each other so that meaningful and sustained system strengthening can take place. METHODS: In this paper, we describe the partnership building model of an international NGO, Kybele, which is committed to achieving childbirth safety through sustained partnerships in low resource settings. The Kybele model adapts generic stages of successful partnerships documented in the literature to four principles relevant to Kybele's work. A multiple-case study approach is used to demonstrate how the model is applied in different country settings. RESULTS: The four principle of Kybele's partnership model are robust drivers of successful partnerships in diverse country settings. CONCLUSIONS: Much has been written about the need for multi-country partnerships to achieve sustainable outcomes in global health, but few papers in the literature describe how this has been achieved in practice. A strong champion, support and engagement of stakeholders, co-creation of solutions with partners, and involvement of partners in the delivery of solutions are all requirements for successful and sustained partnerships.

Transforming Maternal and Neonatal Outcomes in Tertiary Hospitals in Ghana: An Integrated Approach for Systems Change.

OBJECTIVE: In Ghana, regional referral facilities by design receive a disproportionate number of high-risk obstetric and neonatal cases and therefore have mortality rates higher than the national average. High volumes and case complexity result in these facilities experiencing unique clinical, operational, and leadership challenges. In order to improve outcomes in these settings, an integrated approach to strengthen the overall system is needed. METHODS: Clinical skills strengthening, quality improvement training, and leadership skill building have all been used to improve maternal and neonatal outcomes with some degree of success. We present here a customized model tailored to the particular context of tertiary referral hospitals that develops these three skills simultaneously, so that the complex interaction between clinical conditions, resource constraints, and organizational issues that affect the lives of mothers and babies can be considered together. This model uses local data to identify the drivers of poor maternal and neonatal outcomes and creates an integrated training package to focus on approaches to addressing these drivers. Based on this training, quality improvement projects are introduced to change the appropriate clinical or operational processes, or to strengthen organizational leadership. RESULTS: In testing in one of the largest referral hospitals in Ghana, the model has been well received and has improved performance in several cross-cutting areas affecting the quality of maternal and neonatal care, such as triage, patient flow, and NICU hand hygiene. CONCLUSION: An integrated approach to systems strengthening in referral hospitals holds much promise for improving outcomes for mothers with high-risk pregnancies and babies in Ghana and in other low-resource settings.

Objectif : Au Ghana, les établissements de recours régionaux reçoivent, de par leur nature, un nombre disproportionné de cas obstétricaux et néonataux exposés à des risques élevés; par conséquent, ces établissements comptent des taux de mortalité plus élevés que la moyenne nationale. Les volumes élevés et la complexité des cas font en sorte que ces établissements ont à faire face à des défis cliniques, opérationnels et de direction particuliers. Dans de telles situations, l'amélioration des issues nécessite la mise en œuvre d'une approche intégrée visant à renforcer le système dans sa globalité. Méthodes : Le renforcement des compétences cliniques, la formation en amélioration de la qualité et la consolidation des compétences propres au leadership sont des outils qui ont tous été utilisés, avec un certain succès, pour améliorer les issues maternelles et néonatales. Nous présentons ici un modèle, ayant été adapté au contexte particulier des hôpitaux de recours tertiaires, qui favorise la mise en œuvre simultanée de ces trois outils, de façon à ce que l'interaction complexe entre les conditions cliniques, les contraintes en matière de ressources et les facteurs organisationnels qui affectent la vie des mères et des enfants puisse être envisagée dans son ensemble. Ce modèle utilise des données locales pour identifier les éléments associés à l'obtention de piètres issues maternelles et néonatales, pour ensuite créer un programme intégré de formation axé sur des approches permettant d'aborder ces éléments. En fonction de ce programme de formation, des projets d'amélioration de la qualité sont mis en œuvre pour modifier les processus cliniques ou opérationnels appropriés, ou pour renforcer le leadership organisationnel. Résultats : Dans le cadre de sa mise à l'essai au sein de l'un des plus importants hôpitaux de recours du Ghana, ce modèle a été bien reçu et a permis une amélioration du rendement dans plusieurs domaines transsectoriels affectant la qualité des soins maternels et néonataux, comme le triage, le roulement des patientes et l'hygiène des mains en UNSI. Conclusion : La mise en œuvre d'une approche intégrée envers le renforcement des systèmes au sein des hôpitaux de recours s'avère fort prometteuse pour l'amélioration des issues chez les mères connaissant des grossesses exposées à des risques élevés et les nouveau-nés du Ghana et d'autres milieux ne disposant que de faibles ressources.

Targeting α4ß7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.

α4ß7 integrin-expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-α4ß7 monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIVmac251. In treated animals that became infected, the GALT was significantly protected from infection and CD4(+) T cell numbers were maintained in both the blood and the GALT. Thus, targeting α4ß7 reduces mucosal transmission of SIV in macaques.