Assuntos
Analgésicos/farmacologia , Aprendizagem da Esquiva/efeitos dos fármacos , Peptídeos/farmacologia , Receptores Opioides/metabolismo , Extratos do Timo/farmacologia , Adjuvantes Imunológicos/farmacologia , Animais , Masculino , Naloxona/farmacologia , Antagonistas de Entorpecentes/farmacologia , Ratos , Ratos Wistar , Receptores Opioides/agonistasRESUMO
The interaction between neurotransmitter systems and opioid system in rats of different strains was studied during learning and emotional stress. The interaction between noradrenergic, serotoninergic, and opioid systems in the brain is the main neurochemical mechanism underlying learning reinforced by nociceptive electrical stimulation, which determine individual differences in the rate and type of learning.
Assuntos
Aprendizagem da Esquiva/fisiologia , Monoaminas Biogênicas/metabolismo , Encéfalo/metabolismo , Peptídeos Opioides/metabolismo , Estresse Psicológico/metabolismo , Estresse Psicológico/psicologia , Animais , Monoaminas Biogênicas/análise , Estimulação Elétrica , Masculino , Ratos , Ratos Mutantes , Estresse Psicológico/genéticaRESUMO
Experiments were performed on rats with opium abuse induced by chronic administration of morphine in increasing doses. We studied the effect of HLDF-6 peptide on symptoms of naloxone abstinence. Repeated administration of HLDF-6 peptide in a dose of 0.2 mg/kg 24 and 0.5 h before naloxone relieved the major symptoms of the abstinence syndrome. A possible neurochemical mechanism underlying the effect of HLDF-6 peptide is inhibition of enkephalinase A in structures of the endogenous antinociceptive system.
Assuntos
Dependência de Morfina/tratamento farmacológico , Proteínas de Neoplasias/uso terapêutico , Inibidores de Proteases/uso terapêutico , Síndrome de Abstinência a Substâncias/tratamento farmacológico , Animais , Comportamento Animal/efeitos dos fármacos , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Química Encefálica , Modelos Animais de Doenças , Masculino , Naloxona/farmacologia , Proteínas de Neoplasias/farmacologia , Neprilisina/antagonistas & inibidores , Ratos , Ratos Wistar , Síndrome de Abstinência a Substâncias/diagnósticoRESUMO
We studied the effect of bioactive peptide HLDF-6 on functional activity of the endogenous antinociceptive system in the offspring of morphine-tolerant animals. Disturbances in this system included changes in the thermonociceptive threshold and enkephalinase A activity in various brain structures. The peptide acted as a potent regulator of the homeostasis in systems responsible for the synthesis and catabolism of endogenous opioids. HLDF-6 effectively corrected disorders of the endogenous antinociceptive system.
Assuntos
Tolerância a Medicamentos/fisiologia , Morfina/farmacologia , Entorpecentes/metabolismo , Proteínas de Neoplasias/metabolismo , Dor/metabolismo , Fragmentos de Peptídeos/metabolismo , Animais , Animais Recém-Nascidos , Encéfalo/metabolismo , Feminino , Homeostase , Masculino , Neprilisina/antagonistas & inibidores , Neprilisina/metabolismo , Medição da Dor , Ratos , Ratos WistarRESUMO
The use of naloxone hydrochloride (0.2-0.4 mg) in complex therapy of adolescent heroin addicts significantly prolonged the half-life of serum leu-enkephalin, slightly elevated the thresholds of thermal nociceptive reactions, and improved some clinical indices (considerably reduced drug addiction, eliminated affective disorders, etc.), which are important for deactualization of drug addiction and promoting remission.
