The effect of teriparatide on patients with atypical femur fractures: a systematic review and meta-analysis.

INTRODUCTION: Bisphosphonates (BPs) are one of the most often used drugs to lower fracture risk in osteoporosis patients; nonetheless, BPs have been linked to atypical femoral fracture (AFF). Teriparatide (TPTD) is a parathyroid hormone analogue and anabolic drug that may accelerate fracture repair. TPTD has been considered as a possible treatment for AFF, particularly those caused by BP use. We evaluate the effect of TPTD on AFF in this systematic review and meta-analysis. MATERIALS AND METHODS: A thorough search of: Web of Science, Scopus, PubMed, and Cochrane was conducted on August 2, 2023. Trials evaluating the effect of TPTD on the incidence of: complete bone healing, non-union, early and delayed bone union, progression of incomplete AFF to complete AFF, and time to bone union were included. Using Review Manager (RevMan) version 5.4, the risk ratio (RR) and mean difference (MD) with the corresponding 95% confidence interval (CI) were estimated for dichotomous and continuous outcomes, respectively. The Newcastle-Ottawa Scale was used to assess the quality of studies. RESULTS: Eight studies met the eligibility criteria and were included in our analysis. TPTD significantly increased the incidence of early bone union (RR = 1.45, 95% CI [1.13, 1.87], P = 0.004) and time to bone union (MD = -1.56, 95% CI [-2.86, -0.26], P = 0.02) compared to the control group. No significant differences were observed in terms of complete bone healing (RR = 1.09, 95% CI [0.99, 1.13], P = 0.12), non-union (RR = 0.48, 95% CI [0.22, 1.04], P = 0.06), and progression of incomplete AFF to complete AFF (RR = 0.27, 95% CI [0.04, 1.97], P = 0.19). CONCLUSIONS: TPTD is an effective therapy for enhancing and hastening healing following AFF, particularly in postoperative settings. Future large randomized clinical trials are needed to confirm or dispute the results.

Case report of Hand salvage post burn using pedicled tensor fascia lata (TFL).

INTRODUCTION AND IMPORTANCE: Burn still the major cause of disabilities and challenge facing both patient and surgeon, and when hands were affected a comprehensive planning and work must be obtained to restore functional and aesthetic aspects of hand. Tensor fascia lata (TFL) considered since centuries a useful tool to save hand post burn either it was been harvested with pedicle or as free flap. Although pedicle TFL became seldom but it may be the best option for hand reconstruction. In this article we report a case of hand burn that was managed by pedicle TFL. CASE PRESENTATION: A 32 year- old man was involved in thermal burn affected multiple areas of his torso and limbs. He was referred to hospital from primary health care center. At hospital reassessment of the patient done was hemodynamic stable and inhalation injury was excluded. Burn estimated at 36 % total body surface area (TBSA) distributed through trunk and left upper limb, but left hand was the most affected area. CLINICAL DISSOCIATION: After stabilization, he underwent serial debridement and dorsum of hand became skeletonized with exposed bones and tendon. Pedicled tensor fascia lata eventually choose to resurface hand, and fortunately enough covered all hand. CONCLUSION: Tensor fascia late flap still has favorable use, easy applicable and expected outcome. in this article we report post burn hand injury that managed by pedicled tensor fascia lata.

Novel encryption for color images using fractional-order hyperchaotic system.

The fractional-order functions show better performance than their corresponding integer-order functions in various image processing applications. In this paper, the authors propose a novel utilization of fractional-order chaotic systems in color image encryption. The 4D hyperchaotic Chen system of fractional-order combined with the Fibonacci Q-matrix. The proposed encryption algorithm consists of three steps: in step#1, the input image decomposed into the primary color channels, R, G, & B. The confusion and diffusion operations are performed for each channel independently. In step#2, the 4D hyperchaotic Chen system of fractional orders generates random numbers to permit pixel positions. In step#3, we split the permitted image into 2 × 2 blocks where the Fibonacci Q-matrix diffused each of them. Experiments performed where the obtained results ensure the efficiency of the proposed encryption algorithm and its ability to resist attacks.

Ceria-containing uncoated and coated hydroxyapatite-based galantamine nanocomposites for formidable treatment of Alzheimer's disease in ovariectomized albino-rat model.

This paper upraises delivery and therapeutic actions of galantamine drug (GAL) against Alzheimer's disease (AD) in rat brain through attaching GAL to ceria-containing hydroxyapatite (GAL@Ce-HAp) as well ceria-containing carboxymethyl chitosan-coated hydroxyapatite (GAL@Ce-HAp/CMC) nanocomposites. Physicochemical features of such nanocomposites were analyzed by XRD, FT-IR, Raman spectroscopy, UV-vis spectrophotometer, N2-BET, DLS, zeta-potential measurements, SEM, and HR-TEM. Limited interactions were observed in GAL@Ce-HAp with prevailed existence of dispersed negatively charged rod-like particles conjugated with ceria nanodots. On contrary, GAL@Ce-HAp/CMC was well-structured developing aggregates of uncharged tetragonal-shaped particles laden with accession of ceria quantum dots. Such nanocomposites were i.p. injected into ovariectomized AD albino-rats at galantamine dose of 2.5mg/kg/day for one month, then brain tissues were collected for biochemical and histological tests. GAL@Ce-HAp adopted as a promising candidate for AD curativeness, whereas oxidative stress markers were successfully upregulated, degenerated neurons in hippocampal and cerebral tissues were wholly recovered and Aß-plaques were vanished. Also, optimizable in-vitro release for GAL and nanoceria were displayed from GAL@Ce-HAp, while delayed in-vitro release for those species were developed from GAL@Ce-HAp/CMC. This proof of concept work allow futuristic omnipotency of rod-like hydroxyapatite particles for selective delivery of GAL and nanoceria to AD affected brain areas.