[The role of quantitative determination of the volume fraction of interstitial collagen and fibronectin in the pathogenesis of myocardial remodeling in dilated cardiomyopathy]. / Rol' kolichestvennogo opredeliniia ob''emnoi fraktsii interstitsial'nogo kollagena i fibronektina v patogeneze remodelirovaniia miokarda pri dilatatsionnoi kardiomiopatii.

The role of myocardial fibrosis in the pathogenesis of left-ventriclar remodeling was studied in patients with idiopathic and ischemic dilatation cardiomyopathy. The percentage of volumic collagen fraction in the left-ventricular myocardium was significantly increased, this increase correlating with the degree of dilatation of left-ventricular cavity. A sufficient increase of plasma fibromectin level was observed in patients with idiopathic dilatation cardiomyopathy at all stages of circulatory insufficiency.

[Comparative characteristics of left ventricular remodeling in dilatation cardiomyopathy and ischemic disease]. / Sravnitelnaia kharakteristika remodelirovaniia levogo zheludochka pri dilatatsionnoi kardiomiopatii i ishemicheskoi bolezni serdtsa.

Left ventricular remodelling plays an important pathogenetic role in progressive circulatory insufficiency both in dilated cardiomyopathy (DCMP) and in ischemic heart disease with postinfarction cardiosclerosis. In terminal cardiac failure structural changes (changed geometry of the left ventricle, in particular) become stereotypic. The dobutamin test in DCMP reveals low functional reserve of the total and segmentary contractility compared to ischemic cardiomyopathy. This may help in echocardiographic diagnostic difficulties.