Seroprevalence of anti-SARS-CoV-2 antibodies among staff at primary healthcare institutions in Prishtina.

BACKGROUND: Many studies examined the spread of SARS-CoV-2 within populations using seroprevalence. Healthcare workers are a high-risk population due to patient contact, and studies are needed to examine seroprevalence of SARS-CoV-2 antibodies among healthcare workers. Our study investigates the seroprevalence of anti-SARS-CoV-2 antibodies among staff at primary healthcare institutions in Prishtina, and factors associated with seroprevalence. METHODS: We carried out a cross-sectional survey including SARS-CoV-2 serological testing and questionnaires with primary healthcare workers from primary healthcare facilities in the Prishtina, the capital city of Kosovo. We calculated prevalence of anti-SARS-CoV-2 antibodies, and of self-reported positive PCR test among primary healthcare workers, as well as crude and adjusted ORs for explanatory factors. RESULTS: Eighty-three of the healthcare workers (17.47%) tested positive for SARS-CoV-2 antibodies IgG or IgM, while 231 (48.63%) either had antibodies or a previous positive PCR test. Odds of seropositivity were affected by male gender (OR 2.08, 95% CI 1.20, 3.61), and infected family members (OR 3.61, 95% CI 2.25, 5.79) of healthcare workers. Higher education, being part of larger families and having infected family members gave higher odds of positive PCR test and seropositivity. Other healthcare workers had lower odds of positive PCR test and seropositivity than physicians. CONCLUSION: Over 17% of healthcare workers were seropositive for SARS-CoV-2 antibodies and close to half of them were either seropositive or PCR self-reported positive test. Several factors are associated with decreased and increased odds for such outcomes. These findings should be explored further and addressed to Kosovo policy makers, and assist them to intensify vaccination efforts, and maintain control measures until we achieve herd immunity.

Seroprevalence of Anti-SARS-CoV-2 Antibodies among Municipal Staff in the Municipality of Prishtina.

BACKGROUND: Some studies have assessed the seroprevalence of anti-SARS-CoV-2 antibodies in different populations. Very few studies have explored seroprevalence in municipal workers, an important and potentially high-risk population. This study aims to determine the prevalence of anti-SARS-CoV-2 antibodies in municipal workers, with the additional examination of the association of prevalence with various demographic, health-related, and epidemiological factors. METHODS: We surveyed and tested for seroprevalence 418 public servants from the municipality of Prishtina, the capital of Kosovo. The primary prespecified outcome was the seroprevalence of anti-SARS-CoV-2 antibodies, IgG, and IgM. Additional outcomes were crude and adjusted odds ratios of seroprevalence by different factors. RESULTS: 21.1% of municipal workers tested positive for either IgM or IgG. Of these, 9.6% were positive for IgM and 19.4% for IgG. Data showed high levels of adherence to protective measures, e.g., social distancing in the office, but calculation of ORs did not show a significant difference between those reporting adherence to such measures and those reporting nonadherence. Of other examined factors, significantly lower odds were observed for smokers (0.52, 95% CI 0.28, 0.97), while municipal workers with infected family members had elevated odds of seropositivity according to both crude (2.19, 95% CI 1.34, 3.59) and adjusted (2.00, 95% CI 1.17, 3.41) ORs. CONCLUSIONS: Most answers from public servants demonstrated compliance to social-distancing policies in the workplace, but analysis of crude and adjusted odds ratios did not suggest a significant effect between municipal workers who followed these guidelines and those who did not. Results from this study help Kosovo policy makers in understanding the level of prevalence of COVID-19 in municipal workers and the effect of different factors on such prevalence. Results from the study could inform future decisions on the design and application of protective measures for municipal workers. Our findings should encourage further research to assess the extent of the spread of COVID-19 to other essential workers in Kosovo, including retail workers.