RESUMO
Solanum torvum is used in Cameroonian traditional medicine for the management of pain and inflammation. The present work assesses the pain-killing and anti-inflammatory properties of the aqueous extracts of Solanum torvum leaves. Acetic acid- and pressure- induced pains were reduced by this extract while carrageenan-induced inflammation was inhibited at various doses of the extract. The extract therefore has both analgesic and anti-inflammatory properties
Assuntos
Analgésicos , Humor Aquoso , Inflamação , SolanumRESUMO
Solanum torvum is used in Cameroonian traditional medicine for the management of pain and inflammation. The present work assesses the pain-killing and anti-inflammatory properties of the aqueous extracts of Solanum torvum leaves. Acetic acid- and pressure- induced pains were reduced by this extract while carrageenan-induced inflammation was inhibited at various doses of the extract. The extract therefore has both analgesic and anti-inflammatory properties
Assuntos
Analgésicos , Anti-Inflamatórios , Extratos Vegetais , SolanumRESUMO
Solanum torvum is used in Cameroonian traditional medicine for the management of pain and inflammation. The present work assesses the pain-killing and anti-inflammatory properties of the aqueous extracts of Solanum torvum leaves. Acetic acid- and pressure- induced pains were reduced by this extract while carrageenan-induced inflammation was inhibited at various doses of the extract. The extract therefore has both analgesic and anti-inflammatory properties.
Assuntos
Artrite/tratamento farmacológico , Interleucina-10/biossíntese , Receptores de Interleucina-1/antagonistas & inibidores , Sialoglicoproteínas/uso terapêutico , Fator de Necrose Tumoral alfa/biossíntese , Antirreumáticos/uso terapêutico , Doenças Autoimunes/tratamento farmacológico , Humanos , Proteína Antagonista do Receptor de Interleucina 1 , Interleucina-10/antagonistas & inibidores , Masculino , Pessoa de Meia-Idade , SíndromeRESUMO
The effect of leaf aqueous extract of Bidens pilosa Linn. on KCl- and norepinephrine-induced contractions of rat aortic strips was studied. In aortic strips with endothelium intact, contractions induced using 60 mM KCl and 10(-5) M norepinephrine were dose-dependently relaxed by the extract, a more significant effect being seen with norepinephrine-induced contractions. Following mechanical damage to the aortic endothelium, inhibition of contractions was more prominent (105%) with the norepinephrine-induced contractions compared with KCl-induced contractions (15%) when the maximal dose (8 mg/ml) of the extract was used. The results suggest that the relaxation effect of the extract may be due to the blockade of the influx of extracellular Ca2+ into the cell.