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Environ Health Prev Med ; 24(1): 8, 2019 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-30684957

RESUMO

BACKGROUND: In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with cadmium nephropathy in two core medical institutes in cadmium-polluted areas in Akita prefecture, Japan. METHODS: Subjects for this screening were selected from patients aged 60 years or older with elevated serum creatinine levels and no definite renal diseases. We enrolled 35 subjects from a hospital in Odate city and 22 from a clinic in Kosaka town. Urinary ß2-microglobulin and blood and urinary cadmium levels were measured. RESULTS: The criteria for renal tubular dysfunction and the over-accumulation of cadmium were set as a urinary ß2-microglobulin level higher than 10,000 µg/g cr. and a blood cadmium level higher than 6 µg/L or urinary cadmium level higher than 10 µg/g cr., respectively. Subjects who fulfilled both criteria were diagnosed with cadmium nephropathy. Six out of 57 patients (10.5% of all subjects) had cadmium nephropathy. CONCLUSIONS: This hospital-based screening is a very effective strategy for detecting patients with cadmium nephropathy in cadmium-polluted areas, playing a complementary role in health examinations for local inhabitants. REGISTRATION NUMBER: No. 6, date of registration: 6 June, 2010 (Akita Rosai Hospital), and No. 1117, date of registration: 26 December, 2013 (Akita University).


Assuntos
Intoxicação por Cádmio/complicações , Intoxicação por Cádmio/urina , Cádmio/efeitos adversos , Cádmio/urina , Poluentes Ambientais/efeitos adversos , Nefropatias/induzido quimicamente , Idoso , Idoso de 80 Anos ou mais , Intoxicação por Cádmio/sangue , Creatinina/urina , Exposição Ambiental/efeitos adversos , Monitoramento Ambiental , Poluentes Ambientais/urina , Feminino , Hospitais , Humanos , Japão , Nefropatias/urina , Masculino , Pessoa de Meia-Idade , Distribuição por Sexo
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