RESUMO
The aim of the present study was to assess the feasibility of intraosseous anaesthetic drug administration in domestic pigeons and to compare this method with an intramuscular technique for clinical parameters (induction quality and recovery of anaesthesia), heart-respiratory rate and cloacal temperature. Sixteen clinically healthy mature pigeons (7 male and 9 female) were included into the study. The birds were allocated into two groups as group I and II. Pigeons in group I received 50mg/kg ketamine by intraosseous route (IO) and birds in group II received intramuscular (IM) ketamine application at a dose of 50mg/kg. Heart rate (HR), respiratory rate (RR) and cloacal temperature (CT) were measured before (0 min) and 1, 3, 5, 10, 15, 20 and 30 min after anaesthetic drug administration. Clinical and anaesthetic effect of the ketamine used in different route were assessed. Statistical assessment performed between the groups revealed that RR in IM group was higher than in IO group between 1 and 3 min (p<0.001 and p<0.01, respectively), whereas in 15 min it was higher in IO group than IM (p<0.01) (Fig. 1A). Compared to baseline values, there was a decrease for HR within 3 to 15 min for both groups. However, this was statistically different between 5, 10 and 15 min for IM group. No significant alterations were recorded for CT during the anaesthesia for both groups. The anaesthetic effect of the ketamine started 1 to 3 min (1.8+/-0.4) after injection for Group I and 5 to 10 min (7.5+/-0.8) for Group II. The recovery time ranged from 50 to 75 min (62+/-15) for Group I and 80 to 100 min (90+/-12) for the Group II. Intraosseous and intramuscular ketamine administration resulted in a satisfactory anaesthesia in pigeons. However, intraosseous drug administration provided a more rapid and effective anaesthesia and might be useful for the birds requiring urgent anaesthesia.
Assuntos
Anestesia/veterinária , Anestésicos/administração & dosagem , Columbidae , Ketamina/administração & dosagem , Anestésicos/farmacologia , Animais , Feminino , Infusões Intraósseas/veterinária , Ketamina/farmacologia , MasculinoRESUMO
The aim of this work was to determine the effect of dietary vitamin E intake on lipid peroxidation (LPO) by measuring thiobarbituric acid reactive substances (TBARS), vitamin E and reduced glutathione (GSH) levels, and glutathione peroxidase (GSH-Px: EC 1.11.1.9) activity in plasma, red blood cells (RBC), livers, and kidneys of rabbits dosed with cadmium (Cd). Six-month-old clinically healthy New Zealand White rabbits (8 in each group) were given tap water only, containing 1 g CdCl2/L, or tap water with CdCl2 plus vitamin E (100 mg dl-alpha-tocopheryl acetate in 0.2 mL corn oil) daily for 30 days. The vitamin E level in the plasma, liver, and kidneys was significantly higher in the control than in the Cd-only group, and TBARS levels were significantly lower. There were no statistical differences between the control and Cd-only groups GSH-Px activities and GSH levels in RBC, liver, and kidneys. Vitamin E levels in plasma, liver, and kidneys and GSH-Px activity in RBC were higher in the vitamin E group than in both control and Cd-only groups. However, the TBARS levels of RBC, liver, and kidneys in vitamin E administered group were decreased. Therefore, the present study demonstrates the effectiveness of vitamin E in reducing oxidative stress in Cd-treated rabbits and suggests that reductions in increased TBARS due to Cd toxicity may be an important factor in the action of vitamin E.