RESUMO
The current study was performed to examine the effect of 50% surface PEGylation on the plasma circulation, biodistribution and metabolism of intravenously administered Generation 4 poly-L-lysine dendrimers in rats. Partial surface PEGylation blocked the rapid and extensive vascular binding previously described for the non-PEGylated dendrimer and slowed metabolism of the core, however the effect was less than that observed for total surface coverage of PEG. Capping the residual surface amines with acetyl groups further improved plasma stability.
Assuntos
Dendrímeros/química , Polietilenoglicóis/química , Polilisina/análogos & derivados , Animais , Cátions/metabolismo , Cromatografia em Gel , Dendrímeros/farmacocinética , Injeções Intravenosas , Masculino , Polietilenoglicóis/farmacocinética , Polilisina/sangue , Polilisina/química , Polilisina/farmacocinética , Ratos , Ratos Sprague-Dawley , Distribuição TecidualRESUMO
This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to "carbonyl stress" during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.
