Carcinogenic effects of cadmium on the prostate of the rat.

The carcinogenic effects of cadmium were tested in an animal experiment to check the results of epidemiological studies showing that the incidence of prostatic carcinoma is above average in workers industrially exposed to high cadmium levels. For this purpose 1.9 mg CdCl2 (1.2 mg Cd/kg body weight) was injected into the right ventral prostatic lobe of 12-month-old male inbred rats of the Okamoto-toki strain. Simple hyperplasia was found in 38, atypical hyperplasia in 29, atypical hyperplasia with severe dysplasia in 11 and invasive prostatic carcinoma in 5 of 100 animals 270 days after the injection. Various mechanisms are discussed in connection with the carcinogenic action of cadmium.

[Radical prostatovesiculectomy in the treatment of prostate cancer. Indications, operative technic and personal results]. / Die radikale Prostatovesikulektomie in der Behandlung des Prostatakarzinoms. Indikation, Operationstechnik und eigene Ergebnisse.

Cancer of the prostate is the most common form of carcinoma in males of advanced age. If treated at an early stage, it can be healed by prostatovesiculectomy. Rectal prophylactic examination of all males aged 45 years or more should therefore be performed on a larger scale in order to detect these carcinomas as early as possible. Radical operation is indicated in males younger than 70 years old from stage T1 up to stages T3 and M0. Criteria vary in regard of the N-categories. The surgical technique practiced in the perineal and retropubic approach to prostatovesiculectomy is described, advantages and disadvantages are dealt with. No complete urinary incontinence could be observed in the 20 patients who underwent this operation at our hospital. Only 1 patient suffers from severe stress-induced incontinence, all others experiencing no difficulty in this respect. In 2 cases rectal lesions occurred during the operation. Postsurgical strictures occurring in the region of the urethra-bladder anastomosis in 2 other patients could be eliminated by internal urethrotomy. Impotence is the most common complication following this operation.

[Organ preservation in intra- and extracorporeal kidney surgery]. / Organkonservierung bei intra- und extrakorporaler Nierenchirurgie.

With the help of cases of own patients is reported on the possibility of organ preservation in intra- and extracorporal renal surgery. In 5 patients with tumours, 3 patients with coral calculi and one patient with an extended disease of the ureter five times the extracorporal renal surgery with following autotransplantation and initial pulsatile fall stream perfusion was performed. Four times the in-situ-perfusion with hypothermic Collins solution and in-situ-operation was performed. Indication and advantages for the different methods are demarcated.

[A contribution to bladder amyloidosis]. / Ein Beitrag zur Harnblasenamyloidose.

It is reported on a localised primary amyolidosis of the urinary bladder with a progressing course. In contrast to the prevailing observations of other authors during two years an increasing bilateral urinary stasis developed so that finally after an at first unilateral nephrostomy due to an infected retention kidney the bilateral ureter-intestine-anastomosis became necessary. Apart from a short description of the amyloidosis from the general and especially urologi-al point of view it is particularly referred to diagnostic difficulties, since the various forms of amyloidosis have a different prognosis and demand a therapy.