1.
Pancreas
; 51(10): e117-e118, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37099794
2.
Ugeskr Laeger
; 182(12)2020 03 16.
Artigo
em Dinamarquês
| MEDLINE
| ID: mdl-32285771
RESUMO
Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.