1.
Bioorg Med Chem Lett
; 13(9): 1527-30, 2003 May 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12699747
RESUMO
To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation.