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Elife ; 112022 11 22.
Artigo em Inglês | MEDLINE | ID: mdl-36412091

RESUMO

We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the identification of enriched predicted binding sites of transcription factors known to cause demethylation and to be involved in astrocytic/glial lineage specification, point to a shared ontogeny between these glioblastomas and astroglial progenitors. At functional level, increased invasiveness, at least in part mediated by SRPX2, and macrophage infiltration characterise this subset of glioblastoma.


Assuntos
Neoplasias Encefálicas , Glioblastoma , Humanos , Adulto , Glioblastoma/patologia , Neoplasias Encefálicas/genética , Astrócitos/metabolismo , Metilação de DNA , Epigenômica
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