The association between higher cardiac troponin levels and the development of left ventricular diastolic dysfunction in septic patients with diabetes mellitus.

This study was designed to retrospectively analyze the relationship between the levels of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) and the development of left ventricular diastolic dysfunction (LVDD) in septic patients with diabetes mellitus. Furthermore, the predictive value of cTnT and cTnI in the LVDD development in those patients was investigated. The clinical information of 159 septic patients with diabetes mellitus treated in the intensive care unit of Affiliated Hospital of Chengde Medical University from June 2016 to January 2023 were retrospectively analyzed. These patients were separated into LVDD group (LVFP > 15 mmHg) and non-LVDD group (LVFP ≤ 15 mmHg) based on left ventricular filling pressure (LVFP). The differences in clinical data, echocardiographic parameters, as well as cTnT and cTnI levels between the LVDD and non-LVDD groups were compared. The relationship between the cTnT and cTnI levels and the echocardiographic parameters was studied using Pearson correlation analysis. Logistic regression analysis was conducted to explore the factors that influenced the LVDD development in septic patients with diabetes. Receiver operator characteristic (ROC) curves were created to evaluate the predictive value of cTnT and cTnI levels for the LVDD development in septic patients with diabetes. Totally 159 septic patients with diabetes were included in this study, with 97 patients in the LVDD group and 62 in the non-LVDD group. Compared with the non-LVDD group, patients in the LVDD group had much lower left ventricular (LV) early diastolic peak inflow velocity (E), LV advanced diastolic peak inflow velocity (A), E/A, and early diastolic mitral annular velocity (Em) while significantly higher E/Em. The LVDD group showed much higher levels of cTnI and cTnT than the non-LVDD group (P < 0.05). Significant positive correlation between log10cTnI level and E/Em ratio (r = 0.425, P < 0.001) was revealed by the Pearson correlation analysis. Multivariate analysis showed that E/A, E/Em, cTnI and cTnT were independent risk factors for the LVDD development in septic patients with diabetes (P < 0.05). As for ROC curve results, the area under the curve (AUC) of cTnT to predict the development of LVDD in septic patients with diabetes was 0.849 (95% CI 0.788-0.910, P < 0.001); the AUC of cTnI was 0.742 (95% CI 0.666-0.817, P < 0.001). Both cTnT and cTnI are independent risk factors and have predictive value for the LVDD development in septic patients with diabetes mellitus.

[Construction and evaluation of a nomogram prediction model for periprosthetic fractures after total hip arthroplasty].

OBJECTIVE: To construct and evaluate nomogram prediction model for periprosthetic fractures in patients undergoing total hip arthroplasty (THA). METHODS: A total of 538 patients who underwent THA from April 2013 to February 2019 were selected as the research subjects, including 318 males and 220 females, aged 40 to 60 years old with an average age of (50.79±6.37) years old. All patients with THA were divided into non-fracture group (506 patients) and fracture group (32 pathents) according to the 3-year follow-up results. Univariate and multivariate Logistic regression analyses were performed to analyze the influencing factors of postoperative periprosthetic fractures in patients with THA. A nomogram prediction model for periprosthetic fractures in patients undergoing THA was constructed, and the validity and discrimination of the prediction model were evaluated. RESULTS: The proportion of patients with osteoporosis, trauma history, and hip revision in the fracture group were higher than those in the non-fracture group(P<0.05), and the proportion of bone cement prosthesis was lower than that in the non-fracture group(P<0.05). The osteoporosis status[OR=4.177, 95%CI(1.815, 9.617), P<0.05], trauma history[OR=7.481, 95%CI(3.104, 18.031), P<0.05], and hip revision[OR=11.371, 95%CI(3.220, 40.153, P<0.05] were independent risk factors for postoperative periprosthetic fractures in patients undergoing THA, cemented prosthesis [OR=0.067, 95%CI(0.019, 0.236), P<0.05] was an independent protective factor for postoperative periprosthetic fractures in patients undergoing THA(P<0.05). Hosmer-Lemeshow goodness of fit test showed that χ2=7.864, P=0.325;the area under the curve (AUC) for periprosthetic fractures in patients undergoing THA was 0.892 with a sensitivity of 87.5% and a specificity of 77.7% by receiver operating characteristic(ROC) curve. CONCLUSION: The nomogram prediction model for periprosthetic fractures after THA constructed in this study has good discrimination, which is beneficial to clinical prediction of periprosthetic fractures in patients undergoing THA, and facilitates individualized fracture prevention.

Streptothiazolidine B, a new cytotoxic alkaloid produced by Streptomyces violaceoruber.

A new cytotoxic alkaloid, named streptothiazolidine B (1), together with three known compounds (2-4), were isolated from Streptomyces violaceoruber. The structure of the undescribed compound was established using 1D and 2D NMR, and HRESIMS. Streptothiazolidine B was isolated and identified as an amide alkaloid with a unique thiazolidine side chain and its absolute configuration was determined by a combination of NOESY experiment and ECD analysis. Streptothiazolidine B exhibited significant cytotoxic activities against two human tumor cell lines, Li-7 and A2780, with IC50 values of 7.8, and 9.1 µM. Meanwhile, compound 4 showed obvious cytotoxic activities against four human tumor cell lines, THP-1, HT29, Li-7 and A2780, with IC50 values ranging from 3.1 to 10.2 µM.

Two cyclotriveratrylene metal-organic frameworks as effective catalysts for Knoevenagel condensation and CO2 cycloaddition with epoxides.

By using a novel imidazole-functional cyclotriveratrylene ligand, two isostructural frameworks, [Cd3(HECTV)(bdc)3]·DMF·6H2O (1) and [Zn3(HECTV)(OH-bdc)3]·3DMF·4H2O (2) (HECTV = 5,6,12,13,19,20-hexaimidazolium-ethoxy-cyclotriveratrylene), were constructed. The two compounds exhibit fascinating 4-fold interpenetration three-dimensional frameworks. There are still large void spaces in the structures despite the interpenetration, which were filled with solvent molecules. Interestingly, 1 demonstrates a single-crystal to single-crystal transformation with the guests changed by a cycloalkane solvent. Strikingly, 1 and 2 feature highly heterogeneous catalytic activities for Knoevenagel condensation and CO2 cycloaddition, respectively. In particular, catalysts 1 and 2 could be reused with good catalytic performance.

Role of photoresponse of π electrons in light-driven DNA dissociations.

The role of photoresponse of π electrons in light-driven DNA dissociations is theoretically studied. A new model combining the Peyrard-Bishop-Dauxois model and the charge ladder model is first proposed. Then the evolutions of π-electronic states and H-bond stretching in the light-driven DNA dissociations are studied. The results show that light irradiation will induce ultrafast charge redistribution among bases, leading to the precursory insulator-to-metallic transition. This electronic transition will assist DNA to dissociate. Effects of screened Coulomb interactions on dissociation dynamics is emphatically discussed. Finally, it is also found that light-driven DNA dissociation preferentially occurs in the adenine-thymine-rich region rather than the guanine-cytosine-rich region.

Transverse electric field modulated tunneling magnetoresistance in a DNA molecular device.

Quantum spin-dependent transport in a ferromagnetic(FM)/DNA/ferromagnetic(FM) device is theoretically investigated based on the lattice Green function method and the Landauer-Büttiker theory. The effect of a transverse electric field on magnetoresistance (MR) of the device is investigated. It is predicted that either the direction or strength of the transverse electric field can change the MR of the device. We suggest a possible application of modulating MR of the FM/DNA/FM device by a transverse electric field.