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Biochem Biophys Res Commun ; 463(3): 235-40, 2015 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-25998391

RESUMO

In animal circadian clock machinery, the phosphorylation program of PERIOD (PER) leads to the spatio-temporal regulation of diverse PER functions, which are crucial for the maintenance of ~24-hr circadian rhythmicity. The peptidyl-prolyl isomerase PIN1 modulates the diverse functions of its substrates by inducing conformational changes upon recognizing specific phosphorylated residues. Here, we show that overexpression of Drosophila pin1, dodo (dod), lengthens the locomotor behavioral period. Using Drosophila S2 cells, we demonstrate that Dod associates preferentially with phosphorylated species of PER, which delays the phosphorylation-dependent degradation of PER. Consistent with this, PER protein levels are higher in flies overexpressing dod. Taken together, we suggest that Dod plays a role in the maintenance of circadian period by regulating PER metabolism.


Assuntos
Ritmo Circadiano , Proteínas de Drosophila/metabolismo , Drosophila/fisiologia , Peptidilprolil Isomerase/metabolismo , Proteínas Circadianas Period/metabolismo , Animais , Linhagem Celular , Drosophila/genética , Peptidilprolil Isomerase de Interação com NIMA , Peptidilprolil Isomerase/genética , Fosforilação , Ligação Proteica , Mapas de Interação de Proteínas , Proteólise , Regulação para Cima
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