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1.
JGH Open ; 4(6): 1031-1036, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33319034

RESUMO

BACKGROUND AND AIM: The purpose of this study was to review and analyze the nature of industry payments to gastroenterology and hepatology (GI) physicians. METHODS: We conducted a retrospective study of open payments (OP) data for the year 2017. Payments to individual physicians were aggregated using a unique physician profile identification number. General payments to Centers for Medicare and Medicaid Services regions were also analyzed. The nature of financial transactions in general payments was reported overall and per physician payment. Research, ownership, and general payments were aggregated and analyzed by drug/device companies. RESULTS: During the study period, more GI physicians received contributions in the form of general payments compared to ownership or research payments. A small percentage of physicians received contributions greater than $100 000. The most frequent contributions were for food and beverages. Only 10 manufacturers made about 71% ($43 271 938) of general payments. CONCLUSIONS: We found that only a small number of GI physicians received a significant portion of industry payments. A large portion of those payments came from drug or device companies. The impact of these payments on gastroenterologists needs to be examined further.

2.
Int J Colorectal Dis ; 33(10): 1349-1357, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29938362

RESUMO

BACKGROUND AND AIMS: The colon cancer survival rate is significantly affected by location, stage, and size of the cancer. Polypectomy was shown be as equally effective as surgery in early-stage colon cancer, but there have been no established clinical guidelines in the management of colon cancer based on the size of the polyp or the tumor location. The aim of our study was to assess the early-stage colon cancer-specific survival rate in patients who underwent endoscopic polypectomy versus surgery, based on size and location of tumor in early-stage colon cancer. METHODS: This is a population-based nationwide study in the USA. RESULTS: Of 13,157 patients, 15.5% underwent endoscopic treatment and 84.5% underwent surgical therapy. For early cancer tumors located in the left colon, polypectomy yielded comparable 5-year survivals to surgery irrespective of size of the tumors. Five-year early cancer-specific survivals were similar for tumors located in the right colon that were < 20 mm in size (94.5 vs 94.3%, p value = 0.94). However, tumors > 20 mm in size that were located in the right colon had better survivals when treated surgically compared to those treated with polypectomy (20-39 mm: 91.8 vs 74.2%; ≥ 40 mm: 92.4 vs 60%, both p values < 0.01). Similar results were obtained on propensity score analysis. CONCLUSIONS: Polypectomy was as effective as surgical therapy for small tumors. For larger tumors, surgical therapy is better than polypectomy for right-sided tumors, but both are equally effective for left-sided tumors.


Assuntos
Neoplasias do Colo , Pólipos do Colo , Colonoscopia/métodos , Idoso , Colo/patologia , Colo/cirurgia , Neoplasias do Colo/mortalidade , Neoplasias do Colo/patologia , Neoplasias do Colo/cirurgia , Pólipos do Colo/patologia , Pólipos do Colo/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Avaliação de Resultados em Cuidados de Saúde , Programa de SEER/estatística & dados numéricos , Taxa de Sobrevida , Carga Tumoral , Estados Unidos/epidemiologia
3.
Biomed Mater ; 12(4): 045008, 2017 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-28357996

RESUMO

Few studies have been reported that focus on developing implant surface nanofiber (NF) coating to prevent infection and enhance osseointegration by local drug release. In this study, coaxial doxycycline (Doxy)-doped polycaprolactone/polyvinyl alcohol (PCL/PVA) NFs were directly deposited on a titanium (Ti) implant surface during electrospinning. The interaction of loaded Doxy with both PVA and PCL NFs was characterized by Raman spectroscopy. The bonding strength of Doxy-doped NF coating on Ti implants was confirmed by a stand single-pass scratch test. The improved implant osseointegration by PCL/PVA NF coatings in vivo was confirmed by scanning electron microscopy, histomorphometry and micro computed tomography (µCT) at 2, 4 and 8 weeks after implantation. The bone contact surface (%) changes of the NF coating group (80%) is significantly higher than that of the no NF group (<5%, p < 0.05). Finally, we demonstrated that a Doxy-doped NF coating effectively inhibited bacterial infection and enhanced osseointegration in an infected (Staphylococcus aureus) tibia implantation rat model. Doxy released from NF coating inhibited bacterial growth up to 8 weeks in vivo. The maximal push-in force of the Doxy-NF coating (38 N) is much higher than that of the NF coating group (6.5 N) 8 weeks after implantation (p < 0.05), which was further confirmed by quantitative histological analysis and µCT. These findings indicate that coaxial PCL/PVA NF coating doped with Doxy and/or other drugs have great potential in enhancing implant osseointegration and preventing infection.


Assuntos
Doxiciclina/farmacologia , Osseointegração/efeitos dos fármacos , Poliésteres/química , Álcool de Polivinil/química , Infecções Estafilocócicas/prevenção & controle , Staphylococcus aureus/química , Staphylococcus aureus/efeitos dos fármacos , Tíbia/fisiologia , Titânio/química , Animais , Doxiciclina/química , Nanofibras , Próteses e Implantes , Ratos , Microtomografia por Raio-X
4.
Can J Gastroenterol Hepatol ; 2016: 6132640, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27559535

RESUMO

Background. Approximately one-fifth of all esophageal cancer cases are defined as early esophageal cancer (EEC). Although endoscopic therapy (ET) has been shown to be equally effective as esophagectomy (EST) in patients with EEC, there is little information comparing the survival outcomes of the two therapies based on anatomical location. Methods. A population-based study was conducted and the data was obtained from Surveillance, Epidemiology, and End Results program. Patients with EEC (i.e., stages Tis and T1a) and treated with either ET or EST were analyzed to compare EEC-related survival for three different locations of tumor. Results. The overall EEC-specific 1-year and 5-year mean (±SE) survival rates were 11.66 ± 0.05 and 52.80 ± 0.58 months, respectively. Tumors located in lower third had better 5-year survival compared to those located in middle third (83.50% versus 73.10%, p < 0.01). However, when adjusted for age, race, gender, marital status, grade, stage of tumor, histological type, and treatment modality, there was no significant difference. Conclusion. The EEC-specific 1-year or 5-year adjusted survival did not differ by anatomic location of the tumor. Therefore, ET might serve as a minimally invasive yet effective alternative to EST to treat EEC.


Assuntos
Neoplasias Esofágicas/mortalidade , Neoplasias Esofágicas/patologia , Esôfago/patologia , Idoso , Análise de Variância , Distribuição de Qui-Quadrado , Intervalo Livre de Doença , Neoplasias Esofágicas/cirurgia , Esofagectomia/mortalidade , Esofagoscopia/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Programa de SEER , Taxa de Sobrevida , Resultado do Tratamento , Estados Unidos/epidemiologia
5.
J Orthop Trauma ; 30 Suppl 2: S21-2, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27441929

RESUMO

OBJECTIVES: The purpose of this video is to describe the equipment, anatomy, and surgical technique of anterior subcutaneous pelvic fixation (INFIX) using pedicle screws and a rod in an Anterior Posterior Compression 3 pelvic fracture, as well as how to distract in lateral compression fractures. METHODS: The equipment required includes standard spine pedicle screw sets with long screws, 70-110 mm in length, and 7 or 8 mm in diameter. The approach is a mini open and one needs to be familiar with the iliac oblique, obturator outlet, and obturator inlet views. The length of the screw is measured from the sciatic notch to the skin, and they are placed so that the head sits just below the skin. The rod is passed just under the skin along the bikini line and the construct compressed or distracted against a c-clamp while monitored with fluoroscopy. In Orthopaedic Trauma Association C type injuries, we leave c-clamps on the outside the screws to reinforce them or use monoaxial screws. The implants are removed at 3-6 months postop. RESULTS: The patients tolerate the implants and are able to sit and stand with out difficulty. Complications include lateral femoral cutaneous nerve irritation, heterotopic bone, loss of fixation if the implants are applied incorrectly. CONCLUSIONS: The INFIX procedure for anterior pelvic fixation is based on standard techniques that are familiar to the Orthopaedic Pelvic Surgeon including supraacetabular screws. Rod bending, rod passing, determining the ideal height of the screws, and distraction/compression maneuvers are demonstrated in this video.


Assuntos
Fixação Interna de Fraturas/instrumentação , Fixação Interna de Fraturas/métodos , Fraturas Ósseas/cirurgia , Parafusos Pediculares , Ossos Pélvicos/lesões , Ossos Pélvicos/cirurgia , Pinos Ortopédicos , Fraturas Ósseas/diagnóstico por imagem , Humanos , Ossos Pélvicos/diagnóstico por imagem , Resultado do Tratamento
6.
Am J Sports Med ; 40(12): 2872-8, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22972849

RESUMO

BACKGROUND: The adverse effects of smoking on various health conditions such as cancer, diabetes, and cardiovascular disease have been well documented. Many orthopaedic conditions, such as fracture healing, wound repair, and bone mineral density, have been reported to be adversely affected by smoking. However, no known systematic reviews have investigated the effects of smoking on ligament and cartilage knee surgery. PURPOSE: We hypothesized that smoking would have a negative influence from both a basic science and clinical outcome perspective on these types of knee surgeries. STUDY DESIGN: Systematic review. METHODS: A systematic review of multiple medical databases was performed evaluating clinical and basic science studies to determine the effects of smoking on ligament and cartilage knee surgery. RESULTS: Fourteen studies were found for inclusion and analysis. Eight of these studies addressed the relationship between smoking and knee ligaments, and 6 investigated the relationship between smoking and articular cartilage. With the exception of 1, all of the basic science and clinical studies exploring the relationship between smoking and knee ligaments found a negative association of smoking, either molecularly, biomechanically, or clinically. One basic science and 3 clinical studies found a negative influence of smoking on articular cartilage of the knee. No studies were found that investigated the relationship of smoking and menisci. CONCLUSION: The current literature reveals a negative influence of smoking on the results of knee ligament surgery, both from a basic science and clinical perspective, implying that smoking cessation would benefit patients undergoing these procedures. The association between smoking and knee articular cartilage was less clear, although the literature still suggests an overall negative influence and highlights the need for further investigation.


Assuntos
Cartilagem Articular/cirurgia , Traumatismos do Joelho/cirurgia , Ligamentos Articulares/cirurgia , Fumar/efeitos adversos , Humanos
7.
J Knee Surg ; 24(3): 175-80, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21980877

RESUMO

We evaluated two newer forms of femoral fixation of hamstring grafts for anterior cruciate ligament reconstruction, the Endobutton direct (Smith and Nephew, Andover, MA) and Femoral intrafix (Depuy Mitek, Raynham, MA), and compare them to devices that have been evaluated in the literature, the AXL Crosspin (Biomet, Warsaw, IN) and Biotransfix II (Arthrex, Naples, FL). Paired hamstring tendon allografts were fixed in the femoral tunnel of 24 cadaveric bovine knees (6 per group) according to each device's specifications. The free ends (tibial sides) were fixed to the materials testing machine via custom-made cryo-clamps. In Phase I, single load to failure and stiffness were evaluated, and in Phase II, peak displacement was evaluated while cyclic loading was performed over 1000 cycles. One-way analyses of variance were performed to test for differences between groups. There were no significant differences in failure load (p = 0.42) or stiffness (p = 0.39) between the fixation devices. There was also no significant difference in peak displacement measured during the cyclic loading phase (p = 0.32). Our findings suggest that the newer generation devices, Endobutton direct and Femoral intrafix, have similar strength in single load to failure and similar peak displacement during cyclic loading as compared with clinically proven Crosspin techniques. These newer devices, which are designed to accommodate for more anatomic femoral tunnel placement, may provide a reasonable alternative without compromising biomechanical properties.


Assuntos
Ligamento Cruzado Anterior/cirurgia , Artroplastia/instrumentação , Fêmur/cirurgia , Fixadores Internos , Animais , Artroplastia/métodos , Bovinos , Traumatismos do Joelho/cirurgia , Articulação do Joelho/fisiologia , Suporte de Carga
8.
J Addict Med ; 3(3): 128-33, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21769008

RESUMO

OBJECTIVES: : Cocaine use is associated with cardiac arrhythmias. Markers of ventricular late potentials, which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG) but not by standard ECG. METHODS: : We evaluated SA-ECG parameters in 60 medically screened, physically healthy, recently abstinent cocaine users (53 males, mean [SD] age, 34.0 [4.6] years; 10.1 [6.0] years of use) and 54 nondrug-using controls (21 males, mean [SD] age 28.4 [7.8] years). SA-ECGs were done periodically for ≤12 weeks of monitored abstinence in 25 cocaine users. We analyzed 3 SA-ECG parameters considered markers of ventricular late potentials: duration of filtered QRS complex, duration of low-amplitude potentials during terminal 40 ms of QRS complex (LAS40), and root mean square voltage during terminal 40 ms of QRS complex (RMS40). RESULTS: : Cocaine users differed significantly from controls in filtered QRS complex (118.5 [11.2] ms versus 111.9 [11.4] ms; P = 0.03) but not in LAS40 (28.9 [8.2] ms versus 30.8 [8.3] ms; P = 0.40) or RMS40 (40.0 [19.8] µV versus 30.2 [20.1] µV; P = 0.06) values. The proportion of subjects with abnormal SA-ECG parameters did not differ significantly between male cocaine users and male controls. There were no significant changes over time in either the mean values or proportion of subjects with abnormal values for any SA-ECG parameter. There were significant gender differences among controls but not among cocaine users. CONCLUSION: : These findings suggest that chronic cocaine use is not associated with a higher prevalence of abnormal SA-ECG parameters in physically healthy users.

9.
Am J Drug Alcohol Abuse ; 34(6): 712-20, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18855243

RESUMO

OBJECTIVES: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) use has been associated with cardiac arrhythmias. Markers of ventricular late potentials (VLP), which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG), but not by standard ECG. METHODS: We evaluated SA-ECG parameters in 21 physically healthy, recently abstinent MDMA users who also used cannabis (11 males, mean [SD] age 23.3 [4.6] years, 2.8 [2.0] years of use), 18 physically healthy cannabis users (8 males, mean [SD] age 26.6 [7.1] years, 11.2 [5.4] years of use) and 54 non-drug-using controls (21 males, mean [SD] age 28.4 [7.8] years). We analyzed three SA-ECG parameters considered markers of VLPs: duration of filtered QRS complex (fQRS), duration of low amplitude potentials during terminal 40 ms of QRS complex (LAS40), and root mean square voltage during terminal 40 ms of QRS complex (RMS40). RESULTS: MDMA users, cannabis users, and non-drug-using controls did not differ significantly from each other in fQRS, LAS40, or RMS40 values or in the proportion of subjects with abnormal SA-ECG parameters. There were significant gender differences among controls, but not among MDMA users. CONCLUSION: These findings suggest that chronic MDMA use is neither quantitatively nor qualitatively associated with a high prevalence of abnormal SA-ECG parameters indicative of VLP markers.


Assuntos
Arritmias Cardíacas/diagnóstico , Eletrocardiografia/métodos , Alucinógenos/efeitos adversos , N-Metil-3,4-Metilenodioxianfetamina/efeitos adversos , Adulto , Arritmias Cardíacas/etiologia , Feminino , Humanos , Masculino , Abuso de Maconha/fisiopatologia , Prevalência , Fatores Sexuais , Adulto Jovem
10.
Am J Drug Alcohol Abuse ; 34(4): 489-98, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18584578

RESUMO

We compared treadmill exercise stress testing (EST) in 28 medically screened, chronic cocaine users with the cardiovascular effects of an IV cocaine challenge (25 mg or 50 mg). All subjects had a clinically normal EST and echocardiography (except 2 subjects had septal wall hypokinesis). The EST produced significantly greater increases in heart rate and rate-pressure product than did the cocaine challenges. These findings suggest that EST may not provide additional diagnostic information in medically screened cocaine users. EST may cause more cardiac work (indicated by heart rate and blood pressure) than intravenous cocaine (at the doses in this study).


Assuntos
Doenças Cardiovasculares/induzido quimicamente , Doenças Cardiovasculares/fisiopatologia , Transtornos Relacionados ao Uso de Cocaína/reabilitação , Cocaína/efeitos adversos , Teste de Esforço , Frequência Cardíaca , Cooperação do Paciente , Abuso de Substâncias por Via Intravenosa/reabilitação , Adulto , Doenças Cardiovasculares/epidemiologia , Doença Crônica , Cocaína/administração & dosagem , Relação Dose-Resposta a Droga , Ecocardiografia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino
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