Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Stud Health Technol Inform ; 302: 821-822, 2023 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-37203505

RESUMO

Predicting important outcomes in patients with complex medical conditions using multimodal electronic medical records remains challenge. We trained a machine learning model to predict the inpatient prognosis of cancer patients using EMR data with Japanese clinical text records, which has been considered difficult due to its high context. We confirmed high accuracy of the mortality prediction model using clinical text in addition to other clinical data, suggesting applicability of this method to cancer.


Assuntos
Aprendizado de Máquina , Neoplasias , Humanos , Prognóstico , Pacientes Internados , Registros Eletrônicos de Saúde , Hospitais
2.
Artigo em Inglês | MEDLINE | ID: mdl-24110944

RESUMO

Vagus nerve stimulation (VNS) is a palliative treatment for intractable epilepsy. Therapeutic mechanisms of VNS have not been elucidated. In this study, we measured the local field potential (LFP) with high-spatial resolution using a microelectrode array in adult rats, and analyzed VNS-evoked phase modulation at a local network level. Eight adult Wistar rats (270 - 330 g) were used. Each rat underwent implantation of VNS system (Cyberonics, Houston, TX., USA) under 1.5% isoflurane anesthesia. One week after implantation, right temporal craniotomy was performed under the same as previous anesthesia. Subsequently, a microelectrode array was placed in the temporal lobe cortex, and LFP was recorded with sampling rate of 1000 Hz. Phase-locking value (PLV) between all pairs of electrodes in varied frequency bands was calculated in order to evaluate the effect of VNS in terms of synchrony of neuronal activities. PLV was calculated both in a normal state and in an epileptic state induced by kainic acid. VNS increased PLV in a normal state, particularly in high-γ band. In an epileptic state, VNS increased PLV in high-γ band, and decreased in d and low-ß bands. VNS modulates synchrony in a band-specific and state-dependent manner. VNS might keep cortical synchrony within the optimal state.


Assuntos
Epilepsia/terapia , Estimulação do Nervo Vago/métodos , Animais , Sincronização Cortical , Epilepsia/induzido quimicamente , Processamento de Imagem Assistida por Computador , Ácido Caínico/toxicidade , Masculino , Microeletrodos , Ratos , Ratos Wistar , Lobo Temporal/cirurgia , Estimulação do Nervo Vago/instrumentação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...