Comparison of parametric and semi-parametric models with randomly right-censored data by weighted estimators: Two applications in colon cancer and hepatocellular carcinoma datasets.

In this study, parametric and semi-parametric regression models are examined for random right censorship. The components of the aforementioned regression models are estimated with weights based on Cox and Kaplan-Meier estimates, which are semi-parametric and nonparametric methods used in survival analysis, respectively. The Tobit based on weights obtained from a Cox regression is handled as a parametric model instead of other parametric models requiring distribution assumptions such as exponential, Weibull, and gamma distributions. Also, the semi-parametric smoothing spline and the semi-parametric smoothing kernel estimators based on Kaplan-Meier weights are used. Therefore, estimates are obtained from two models with flexible approaches. To show the flexible shape of the models depending on the weights, Monte Carlo simulations are conducted, and all results are presented and discussed. Two empirical datasets are used to show the performance of the aforementioned estimators. Although three approaches gave similar results to each other, the semi-parametric approach was slightly superior to the parametric approach. The parametric approach method, on the other hand, yields good results in medium and large sample sizes and at a high censorship level. All other findings have been shared and interpreted.

Modified maximum likelihood estimator under the Jones and Faddy's skew t-error distribution for censored regression model.

It is well-known that classical Tobit estimator of the parameters of the censored regression (CR) model is inefficient in case of non-normal error terms. In this paper, we propose to use the modified maximum likelihood (MML) estimator under the Jones and Faddy's skew t-error distribution, which covers a wide range of skew and symmetric distributions, for the CR model. The MML estimators, providing an alternative to the Tobit estimator, are explicitly expressed and they are asymptotically equivalent to the maximum likelihood estimator. A simulation study is conducted to compare the efficiencies of the MML estimators with the classical estimators such as the ordinary least squares, Tobit, censored least absolute deviations and symmetrically trimmed least squares estimators. The results of the simulation study show that the MML estimators work well among the others with respect to the root mean square error criterion for the CR model. A real life example is also provided to show the suitability of the MML methodology.