RESUMO
This paper studies the terahertz optical properties of nonlinear potassium titanyl phosphate crystals with different conductivities in the spectral range of 0.2 to 2.6 THz. The observed properties are characterized by several absorption lines lying along different optical axes which represent the relevant potassium sublattice phonon modes. The peculiarities of these absorption lines are attributed to the structural order of potassium ions.
Assuntos
Fenômenos Ópticos , Fosfatos/química , Espectroscopia Terahertz , Titânio/química , Absorção de Radiação , Cristalização , Fônons , Refratometria , Temperatura , Fatores de TempoRESUMO
Questions of the identification of the type of pharmacological activity of physiologically active substances (PAS) with a receptor type of action under conditions of screening are examined. IN accordance with current concepts of the theory of the recognition of modes, the type of action of PAS was identified by establishing a set of criteria ("vectors of modes") characteristic of the effect of known substances and by selecting methods of comparing them with the vectors of the modes of the compounds being tested. Test parameters recorded by the the functional multiparametric method permitting identification of the type of the effects and an evaluation of their quantitative manifestations with the framework of a single experimental approach were used as the unknown set of criteria. The method of describing the relative change in the parameters from the dose as the vectors of action was used and the function of proximity (similarity).
Assuntos
Preparações Farmacêuticas/classificação , Receptores de Droga/metabolismo , Animais , Avaliação Pré-Clínica de Medicamentos/métodos , Epinefrina/farmacologia , Norepinefrina/farmacologia , Consumo de Oxigênio/efeitos dos fármacos , Fentolamina/farmacologia , Propranolol/farmacologia , RatosRESUMO
The problem of quantitative evaluation of the pharmacological influence of physiologically active substances with receptor action on the organism under conditions of screening is discussed. A vector-significant criterion, based on a functional multiparameter method (FMM), is suggested as the basic characteristic of effectiveness of action. This criterion permits an evaluation of the latitude of the permissible physiological effect, the threshold of subtoxicity, and the selectivity of the action of the substance according to the dominant activity.
