RESUMO
Sunlight induces clinical, histological and physiological changes in the skin that are known as photoageing. As the population ages, prevention and treatment of photoageing is a growing challenge because of its association with skin cancer as well as for cosmetic reasons. Therefore, it is of interest to assess the degrees of photoageing by developing valid and comprehensive grading systems. Several different methods have been proposed. These include descriptive grading scales, visual analogue scales and photographic grading scales. The merits and inconveniences of these different approaches are discussed.
RESUMO
With respect to the clinical advantages known for bath PUVA therapy, it was of interest to compare the plasma levels of 8-methoxypsoralen (8-MOP) in bath therapy with those after oral administration for a better insight into the pharmacokinetics of 8-MOP following different modes of application. Considerable high plasma levels of 8-MOP were observed after bath therapy with interindividual variability. The half-life of plasma 8-MOP was markedly shorter after bath PUVA than after oral application. The pharmacokinetic profile of 8-MOP differs according to the mode of application.
Assuntos
Banhos , Metoxaleno/administração & dosagem , Metoxaleno/sangue , Terapia PUVA , Fármacos Fotossensibilizantes/administração & dosagem , Fármacos Fotossensibilizantes/sangue , Administração Cutânea , Administração Oral , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Área Sob a Curva , Disponibilidade Biológica , Feminino , Meia-Vida , Humanos , Masculino , Metoxaleno/farmacocinética , Pessoa de Meia-Idade , Fármacos Fotossensibilizantes/farmacocinética , Absorção Cutânea , Dermatopatias/tratamento farmacológico , Dermatopatias/metabolismo , Fatores de Tempo , ÁguaRESUMO
Chronic exposure to sunlight induces clinical, histological and physiological changes that are described as photoaging. To assess the resulting skin changes different clinical and photographic scores have been evaluated. Regarding different scoring systems a standardized grading system would be useful in a variety of indications, in particular to improve the quality of epidemiologic and clinical studies of photodamage. Photonumeric grading is considered superior to descriptive scales; however, the combination of both may suggest an advanced assessment of photodamage.
Assuntos
Fotografação , Envelhecimento da Pele/efeitos da radiação , Luz Solar/efeitos adversos , Humanos , Reprodutibilidade dos Testes , Fenômenos Fisiológicos da PeleRESUMO
Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunteers using non-invasive bioengineering methods, such as measurement of transepidermal water loss and chromametry. N-propanol did not enhance cumulative skin irritation when used with sodium lauryl sulfate, as has been reported for toluene. As n-propanol is the active ingredient in many disinfectants, this is of particular interest regarding occupational skin irritation in health care workers.
