[Validation and approaches to correction of hemorheologic disorders in patients with gastrointestinal cancer]. / Obosnovanie i puti korrektsii gemoreologicheskikh rasstroistv u bol'nykh rakom zheludochno-kishechnogo trakta.

A total of 237 patients were examined: 127 with gastric cancer and 110 with colonic cancer, 99 women and 138 men, mean age 57.5 years. Erythrocyte deformability and aggregation were studied by original methods. Red blood, protein metabolism, and endogenous intoxication parameters were evaluated by routine laboratory tests. Increased aggregation and volume of erythrocytes and decrease of their deformability and hemoglobin content in parallel with hypo- and dysproteinemia and increased level of endogenous intoxication were observed in all patients with gastrointestinal cancer. Correction of these disorders by intravenous laser exposure of the blood essentially improved the erythron status and protein metabolism and decreased endotoxicosis. Infusion/transfusion therapy also notably improved the erythron function and decreased endogenous intoxication. Analysis of the results of surgery showed decreased incidence of complications and lethal outcomes, which was due to methods of corrective therapy.

[Microcirculation in gastrointestinal cancer and some possibilities of its correction]. / Mikrotsirkulatsiia u bol'nykh rakom zheludochno-kishechnogo trakta i nekotorye vozmozhnosti korrektsii eë narushenii.

Microcirculation and blood rheology were studied in 348 patients with tumors of the gastrointestinal tract. Such disorders as increased blood and plasma viscosity, aggregates of erythrocytes and their increased stability of shape were recorded in conjunction with hypo- and dysproteinemia, endogenous intoxication syndrome and microvascular disturbances. Microcirculation significantly improved and endoxemia was alleviated following photomodification of the blood by use of helium-neon laser radiation and application of an original procedure of infusion.

[Blood rheology in patients with gastric cancer]. / Reologicheskie svoistva krovi u bol'nykh rakom zheludka.

Blood rheology was examined in 163 patients with gastric cancer. The 4th stage of the disease was detected in 51 of them. The following changes of blood rheology were found: changes of a blood and plasma viscosity and red blood cells hyperaggregation. These changes lead to hypo- and dysproteinaemia, erythron system disorders, endogenous intoxication, hemostasis disorders which correlated in severity with the disease stage. These patients need correction of rheological disorders.

[A method of determining erythrocyte aggregation in clinical practice]. / Metod opredeleniia agregatsii éritrotsitov v klinicheskoi praktike.

Intensification of the red cell aggregation results in considerable disorders of the hemorheologic characteristics, a most important component in the pathogenesis of many diseases. The author suggests the following method for the diagnosis of hyperaggregation: aggregate formation in the blood diluted 100-fold with autoplasma is examined microscopically with the blood simulating its natural flow in the microcirculatory vessels.

[Evaluation of the degree of endogenous intoxication in oncological patients]. / Otsenka stepeni éndogennoi intoksikatsii u onkologicheskikh bol'nykh.

The paper is concerned with an evaluation of leucocyte index of intoxication, neutrophile/lymphocyte ratio and nuclear index in 55 patients with ovarian malignancies and 74 cases of stage IV lung cancer. Also, the said indexes were followed in 68 cases of gynecologic malignancies and 62 cases of lung cancer after radical surgery. Lymphocytic index of intoxication proved to be instrumental in the evaluation of endogenous intoxication in stage IV lung cancer and ovarian tumors before and after surgery.