RESUMO
BACKGROUND: Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. AIM: To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. METHODS: In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. RESULTS: c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. CONCLUSIONS: The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity.
Assuntos
Herpesvirus Humano 8/imunologia , Proteínas Proto-Oncogênicas c-kit/metabolismo , Sarcoma de Kaposi/imunologia , Neoplasias Cutâneas/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Sarcoma de Kaposi/patologia , Neoplasias Cutâneas/patologiaAssuntos
Alopecia , Adulto , Alopecia/diagnóstico , Alopecia/terapia , Feminino , Humanos , Terminologia como AssuntoRESUMO
Ossifying fibroma localized in the nasopharynx of a 35-year-old man with histopathologic and radiologic findings has been reported. Because of its rarity, the subject has been presented and discussed.
