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1.
Diagn Interv Imaging ; 99(2): 65-72, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28729182

RESUMO

PURPOSE: To assess the relationships between mucosal thickness, T1-weighted, T2-weighted signals and restricted diffusion on magnetic resonance imaging (MRI) with the degree of symptoms in patients with incidentally detected inflammatory sinonasal disease. MATERIALS AND METHODS: Conventional and diffusion-weighted MRI of 100 patients with incidental sinonasal mucosal thickening were prospectively evaluated. There were 53 men and 47 women, with a mean age of 44.6 years±15.17 (SD) (range: 18-81 years). Correlations between quantitative values (T1-signal, T2-signal and apparent diffusion coefficient [ADC]) and three different quality of life questionnaires (chronic sinusitis survey, sinonasal outcomes test-22 and nasal obstruction and septoplasty effectiveness scale [NOSE]) were searched using the Spearman correlation test. RESULTS: The mean SNOT-22 score was 35.81±20.36 (SD) (range: 0-83), CSS score was 4.64±3.42 (SD) (range: 0-14), and NOSE score was 5.91±4.84 (range: 0-18). All patients (100%) had maxillary sinus involvement. Ethmoidal sinus involvement was present in 57% of patients, frontal sinus involvement in 33% and sphenoidal sinus involvement in 27%. Morphologically, 40 patients (40%) had septal deviation, 41 (41%) had maxillary sinus retention cyst and 78 (78%) had hypertrophy of the conchae. No correlations were found between morphological abnormalities, quantitative values and patient scores in none of the questionnaires. CONCLUSION: Incidental morphological abnormalities or restricted diffusion of the paranasal sinuses on MRI do not correlate with the degree of symptoms in patients with incidentally detected inflammatory sinonasal disease.


Assuntos
Imageamento por Ressonância Magnética , Mucosa Nasal/diagnóstico por imagem , Seios Paranasais/diagnóstico por imagem , Sinusite/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Achados Incidentais , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Adulto Jovem
2.
Cardiovasc J Afr ; 26(1): 25-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25475408

RESUMO

BACKGROUND: In this study, we retrospectively reviewed our experience in a meticulously selected group of patients undergoing redo off-pump coronary artery bypass graft (CABG) surgery from the descending aorta to the circumflex artery (Cx) and its branches. METHODS: Between January 2001 and October 2013, 32 patients at our hospital underwent redo off-pump CABG from the descending aorta to the Cx and its branches via a left posterolateral thoracotomy. Of these patients, 27 were male (84.3%) and five were female (15.7%), with a mean age of 61.66 ± 8.63 years. All patients had a patent left internal thoracic artery-to-left anterior descending coronary artery (LITA-LAD) anastomosis. Thoracotomy was performed through the fifth intercostal space. The saphenous vein or radial artery was prepared as a graft at the same time as the left posterolateral thoracotomy from the contralateral extremity, without any positional problem. RESULTS: The main reasons for surgery in this group of patients were new lesion formation in 19, graft occlusion in six, and both in seven patients. The average operating time was 143.90 ± 36.93 minutes, respiratory assist time was 5.08 ± 1.88 hours, intensive care unit (ICU) stay was 21.3 ± 4.41 hours and hospital stay was 5.06 ± 2.74 days. Thirty-eight bypasses were performed. The follow-up period was 56.17 ± 39.2 months. Six patients were lost in the follow-up period and four patients died. Twenty-two were alive and free of cardiac problems. CONCLUSION: Redo off-pump CABG via a left posterolateral thoracotomy provided a safe and effective surgical approach with lower rates of postoperative morbidity and mortality in patients who required revascularisation of the Cx and its branches.


Assuntos
Ponte de Artéria Coronária sem Circulação Extracorpórea/métodos , Doença da Artéria Coronariana/cirurgia , Oclusão de Enxerto Vascular/cirurgia , Anastomose de Artéria Torácica Interna-Coronária , Artéria Radial/transplante , Veia Safena/transplante , Toracotomia , Adulto , Idoso , Ponte de Artéria Coronária sem Circulação Extracorpórea/efeitos adversos , Ponte de Artéria Coronária sem Circulação Extracorpórea/mortalidade , Doença da Artéria Coronariana/diagnóstico , Doença da Artéria Coronariana/mortalidade , Feminino , Oclusão de Enxerto Vascular/diagnóstico , Oclusão de Enxerto Vascular/etiologia , Oclusão de Enxerto Vascular/mortalidade , Humanos , Anastomose de Artéria Torácica Interna-Coronária/efeitos adversos , Anastomose de Artéria Torácica Interna-Coronária/mortalidade , Masculino , Pessoa de Meia-Idade , Seleção de Pacientes , Recidiva , Reoperação , Estudos Retrospectivos , Fatores de Risco , Toracotomia/efeitos adversos , Toracotomia/mortalidade , Fatores de Tempo , Resultado do Tratamento , Turquia
3.
Clin Ter ; 165(2): e145-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24770823

RESUMO

OBJECTIVE: To assess the relation between fetal and maternal blood type (ABO, Rh) incompatibility and development of gestational diabetes mellitus (GDM). MATERIALS AND METHODS: A total of 500 pregnant women underwent diagnostic test for GDM by a 100-g oral glucose tolerance test (OGTT) after an 8 to 12-h overnight fast participated in this study. OGTT was performed between the 24-28 weeks of gestation, but participants who were at high risk for GDM were tested after the first prenatal visit. In the postpartum period, maternal and infant blood types were determined. Presence of GDM was evaluated in terms of matched and unmatched fetal and maternal ABO and Rh blood types separately. RESULTS: GDM was detected in 235 participants. Unmatched ABO blood types between the mother-infant pairs were present in 44.7% (n=105) of GDM (+) and 35.8 % (n=95) of GDM (-) patients. Incompatible feto-maternal ABO blood type was positively correlated with development of GDM which was marginally significant. (p=0.045; R=1.2;95% CL; 1.004-1.48). However, Rh feto-maternal blood type incompatibility was not related with development of GDM. CONCLUSIONS: Feto-maternal ABO blood type incompatibility may be a weak risk factor for the development of GDM.


Assuntos
Sistema ABO de Grupos Sanguíneos , Diabetes Gestacional/etiologia , Isoimunização Rh/complicações , Adulto , Feminino , Humanos , Gravidez , Fatores de Risco
4.
Cell Mol Biol (Noisy-le-grand) ; 58 Suppl: OL1680-7, 2012 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-22762529

RESUMO

We investigated the potential protective effects of Nigella sativa (NS) on mortality, serum levels of proinflammatory cytokines, oxidative stress and histopathological changes in lung tissues, in cecal ligation and puncture (CLP)-induced sepsis model in rats. Sepsis induction by CLP, determination of serum cytokine levels by ELISA, spectrophotometric determination of oxidative stress parameters, and histological examination of lung tissues. The rat groups were: 1) CLP group, 2) sham group, 3) NS500-sham group, 4) NS125, 5) NS250, 6) NS500 groups. NS treatment significantly decreased proinflammatory cytokine levels in serum; LPO level, MPO activity, and pathological changes in lung tissues, in CLP-induced sepsis, while significantly increasing GSH levels and SOD activity in the lung tissue. NS treatment after CLP potentially reduced mortality and may exert effects through the reduction in tissue oxidative stress and serum cytokines. The histopathological changes were minimized in lung tissue by NS, under sepsis conditions. We can suggest that NS reverses the systemic inflammatory reaction to polymicrobial sepsis and thereby reduces multiple organ failure. It may be suggested that role of the NS ethanolic extract in preventing formation of CLP induced sepsis, is due to the anti-inflammatory and antioxidant effects of the different compounds of the black seeds.


Assuntos
Lesão Pulmonar/tratamento farmacológico , Nigella sativa/química , Extratos Vegetais/uso terapêutico , Sepse/complicações , Animais , Ceco , Citocinas/sangue , Modelos Animais de Doenças , Glutationa/metabolismo , Ligadura , Peroxidação de Lipídeos/efeitos dos fármacos , Lesão Pulmonar/etiologia , Lesão Pulmonar/metabolismo , Lesão Pulmonar/patologia , Masculino , Peroxidase/metabolismo , Extratos Vegetais/farmacologia , Punções , Ratos , Ratos Wistar , Superóxido Dismutase/metabolismo
5.
J Endocrinol Invest ; 32(10): 852-6, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19783896

RESUMO

OBJECTIVE: It has been suggested that lipid-lowering treatment with the use of statins adversely affects the steroid hormones. However, the safety of lipid lowering treatment targeting very low levels of LDL with respect to the steroid hormones has not been established. RESEARCH DESIGN AND METHODS: A prospective, randomized, multicenter trial was conducted involving 98 patients. The patients were randomized into 2 groups: group-I received 10 mg of atorvastatin plus 10 mg of ezetimibe and group-II 80 mg of atorvastatin for the first 3 months. After crossover, the first group received 80 mg of atorvastatin and the second group 10 mg of atorvastatin plus 10 mg of ezetimibe for the following 3 months. Cortisol, DHEAS, testosterone, and estradiol levels were measured at the enrollment and at the end of the 1st, 2nd, 3rd, and 6th months. RESULTS: Along with a decrease in LDL level, the levels of DHEAS, testosterone, and estradiol decreased in both groups (p<0.001). While cortisol levels were maintained in the group given 10 mg of atorvastatin plus 10 mg of ezetimibe, it decreased significantly after the crossover to 80 mg of atorvastatin (p<0.001). The group initially given 80 mg of atorvastatin measured a lower level of cortisol for the first 3 months and it returned to normal levels after switching to 10 mg of atorvastatin plus 10 mg of ezetimibe. CONCLUSION: Eighty milligrams of atorvastatin decreased all adrenal and gonadal steroids, whereas 10 mg of ezetimibe combined with 10 mg of atorvastatin had at least no impact on cortisol levels.


Assuntos
Azetidinas/uso terapêutico , LDL-Colesterol/sangue , Diabetes Mellitus Tipo 2/tratamento farmacológico , Ácidos Heptanoicos/uso terapêutico , Pirróis/uso terapêutico , Adulto , Análise de Variância , Anticolesterolemiantes/uso terapêutico , Atorvastatina , Estudos Cross-Over , Desidroepiandrosterona/sangue , Diabetes Mellitus Tipo 2/sangue , Esquema de Medicação , Estradiol/sangue , Ezetimiba , Feminino , Humanos , Hidrocortisona/sangue , Medições Luminescentes , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estatísticas não Paramétricas , Testosterona/sangue , Resultado do Tratamento
6.
Fitoterapia ; 76(2): 216-9, 2005 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15752633

RESUMO

The total antioxidant activity, total phenolic content and reducing power of methanol and water extracts of four lichen species, Bryoria fuscescens, Dermatocarpon intestiniformis, Peltigera rufescens and Pseudevernia furfuracea, were determined in vitro. Water and methanol extracts of P. rufescens showed the highest antioxidant activity. However, there was no correlation between antioxidant activity and total phenolic content of the extracts. Although the methanol extract of P. furfuracea had the highest total phenolic contents, it exhibited low antioxidant activity. In contrast, there was a strong correlation between reducing power and total antioxidant activity of the extracts. The highest reducing power was determined for the methanol extract of P. rufescens.


Assuntos
Antioxidantes/farmacologia , Líquens , Fitoterapia , Extratos Vegetais/farmacologia , Antioxidantes/química , Humanos , Fenóis/química , Extratos Vegetais/química
7.
Phytomedicine ; 10(6-7): 552-7, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-13678242

RESUMO

An aqeuous extract of Lobaria pulmonaria (L.) Hoffm., from which a tea is prepared and consumed as treatment for various diseases in northeastern Turkey, was tested for its anti-inflammatory and antiulcerogenic effects in rats. The carrageenan-induced paw edema, cotton pellet granuloma and indomethacin-induced gastric damage models were used to determine these effects. The extract exhibited moderate anti-inflammatory and strong antiulcerogenic activities.


Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Antiulcerosos/farmacologia , Edema/prevenção & controle , Granuloma de Corpo Estranho/prevenção & controle , Líquens , Fitoterapia , Extratos Vegetais/farmacologia , Úlcera Gástrica/prevenção & controle , Animais , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/uso terapêutico , Antiulcerosos/administração & dosagem , Antiulcerosos/uso terapêutico , Bebidas , Carragenina , Edema/induzido quimicamente , Indometacina , Masculino , Medicina Tradicional , Extratos Vegetais/administração & dosagem , Extratos Vegetais/uso terapêutico , Ratos , Ratos Wistar , Úlcera Gástrica/induzido quimicamente , Chá , Turquia
8.
Ann Thorac Surg ; 64(3): 739-45, 1997 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9307467

RESUMO

BACKGROUND: This study was performed to assess the functional capacity of the survivors of septal myectomy for the treatment of hypertrophic obstructive cardiomyopathy in long-term follow-up as assessed by dobutamine stress echocardiography. METHODS: Sixty-nine patients with hypertrophic obstructive cardiomyopathy underwent septal myectomy between 1975 and 1996. The mean age was 25.4 +/- 13.6 years (range, 6-58 years), and 10 of the patients were women. The early mortality was 4.3%. Hospital survivors (95.7%) were followed up for a mean of 43.8 +/- 28.7 months (range, 6-114 months). RESULTS: The postoperative mean functional capacity of the group was 1.47 +/- 0.56. No late deaths were reported. Forty-nine patients (74.2%) were evaluated with standard echocardiographic techniques, and 29 (43.9%) patients underwent dobutamine stress echocardiography. There was a significant decrease in the thickness of the interventricular septum after surgery. The mean preoperative and postoperative septal thickness was 1.99 +/- 0.59 cm (range, 1.3-3.8 cm) and 1.55 +/- 0.41 cm (range, 0.96-2.8 cm), respectively (p < 0.004). The mean posterior wall thickness was significantly less than the preoperative value (p = 0.008) and the left ventricular end-diastolic diameter was slightly greater in the postoperative measurements, but the difference was not significant (p = 0.162). Postoperative left ventricular outflow systolic gradients were reduced significantly when compared with preoperative values (preoperative mean, 78.4 +/- 33.6 mm Hg, range, 50-212 mm Hg versus postoperative mean, 17.9 +/- 15.9 mm Hg: range, 0-40 mm Hg; p < 0.0001). CONCLUSION: Septal myectomy for patients with hypertrophic obstructive cardiomyopathy is a safe procedure with excellent clinical and functional results in the long-term follow-up.


Assuntos
Agonistas Adrenérgicos beta , Cardiomiopatia Hipertrófica/cirurgia , Dobutamina , Ecocardiografia , Septos Cardíacos/cirurgia , Análise Atuarial , Adolescente , Adulto , Valva Aórtica/anormalidades , Valva Aórtica/cirurgia , Cardiomiopatia Hipertrófica/diagnóstico por imagem , Cardiomiopatia Hipertrófica/fisiopatologia , Criança , Ecocardiografia Doppler , Feminino , Seguimentos , Coração/fisiopatologia , Septos Cardíacos/diagnóstico por imagem , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/cirurgia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Valva Mitral/cirurgia , Segurança , Volume Sistólico , Taxa de Sobrevida , Sístole , Função Ventricular Esquerda , Obstrução do Fluxo Ventricular Externo/cirurgia
9.
Acta Ophthalmol Scand ; 73(3): 246-8, 1995 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7493237

RESUMO

Topical medications have a very important role in chronic glaucoma treatment. Long-term use of these medications can cause significant changes on ocular surfaces. In this study, the ocular surfaces of 20 control subjects (group I), 20 primary open-angle glaucoma patients (group II) treated (mean 21.20 +/- 1.32 months) with 0.50% timolol maleate, and 20 primary open-angle glaucoma patients (group III) treated (mean 21.70 +/- 1.34 months) with 0.50% timolol maleate + 1% dipivefrin hydrochloride were evaluated. Studied parameters included Schirmer's test, tear break-up time, conjunctiva impression cytology and goblet cell density. These results suggest that long-term applications of topical anti glaucoma medications damage the ocular surface.


Assuntos
Agonistas Adrenérgicos/efeitos adversos , Antagonistas Adrenérgicos beta/efeitos adversos , Túnica Conjuntiva/efeitos dos fármacos , Epinefrina/análogos & derivados , Glaucoma de Ângulo Aberto/tratamento farmacológico , Timolol/efeitos adversos , Administração Tópica , Agonistas Adrenérgicos/administração & dosagem , Antagonistas Adrenérgicos beta/administração & dosagem , Adulto , Idoso , Compostos de Benzalcônio/administração & dosagem , Contagem de Células , Túnica Conjuntiva/patologia , Córnea/efeitos dos fármacos , Córnea/patologia , Quimioterapia Combinada , Epinefrina/administração & dosagem , Epinefrina/efeitos adversos , Epitélio/efeitos dos fármacos , Epitélio/patologia , Feminino , Humanos , Aparelho Lacrimal/efeitos dos fármacos , Aparelho Lacrimal/patologia , Masculino , Pessoa de Meia-Idade , Soluções Oftálmicas , Lágrimas/metabolismo , Timolol/administração & dosagem
10.
J Neuroophthalmol ; 14(4): 193-5, 1994 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-7881521

RESUMO

We report on the development of juxtapapillary subretinal neovascular membrane and permanent severe visual loss in a patient with pseudotumor cerebri. The patient was managed by a lumboperitoneal shunt. After surgery, despite resolving papilledema and intracranial pressure control, the membrane had enlarged rapidly to involve the foveal avascular zone, and resulted in rapid visual loss. The membrane slowly regressed, and was replaced by fibrous tissue at the ninth month, causing permanent severe visual loss.


Assuntos
Macula Lutea/patologia , Pseudotumor Cerebral/complicações , Neovascularização Retiniana/etiologia , Adulto , Cegueira/etiologia , Membrana Celular/patologia , Feminino , Angiofluoresceinografia , Fundo de Olho , Humanos , Pressão Intracraniana , Papiledema/etiologia , Neovascularização Retiniana/patologia , Acuidade Visual
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