[The laboratory biochemical markers of severity of trauma in acute period after multiple fractures of bones of extremities].

The article presents results of studying alterations of biochemical indices of blood serum in 47 patients of both genders with multiple fractures of bones of lower extremities occurred in period up to 5 days after trauma. All examined patients were allocated in 5 groups: group I (n=10, average age 41±9 years) - patients received during 24 hours after trauma; group II (n=10, average age 42±7 years) - patients received during 24-48 hours after trauma; group III (n=10, average age 42±6 years) - patients received after 72-96 hours after trauma; group IV (n=8, average age 43±6years) - patients received 72-96 hours after trauma; group V (n=9 average age 39±8 years) - patients received after 96-120 hours after trauma. It is established that in examined patients the higher level of lactate (rate 0.745) and increased activity of aspartate aminotransferase (rate 0.553) are established most often. The high rate of increasing of activity of creatinine phosphatase was marked. The reliable correlation dependence on treatment period had three indices: total creatinine kinase, r=-0.534 (p=0.03); total protein, r=-0.477 (p=0.02) and lactate, r=0.406 (p=0.04). It was established also that average periods of treatment of received patients with both increased activity of total creatine kinase and level of lactate or decreased level of total protein, were reliably higher than average periods of treatment of patients with normal indices at the moment of reception into hospital. These three indices can be included into listing of tests for evaluation of trauma severity in patients with multiple fractures of bones of lower extremities with possibility of application of these tests as additional criteria of monitoring under management of patients in post-traumatic period.

[The laboratory evaluation of pathogenic factors under retarded consolidation of fractures of bones of lower extremities].

The study was carried out to comparatively analyze metabolic profile and content of growth factors in blood serum of patients with retarded consolidation of fractures of bones of lower extremities. The evaluation was applied to concentration of metabolites, growth factors and enzyme activity of blood serum in 13 patients with retarded consolidation of fractures of thigh and shank bones (main group). The comparative group included 14 patients with solid fractures of thigh and shank bones. The analysis established that as compared to patients with solid fractures of bones, in patients with retarded consolidation of fractures blood serum contained reliably higher concentration of triglycerides, products of glycolysis, epidermal growth factor and transforming growth factors TGF-α and TGF-ß2. The content of vitamin E and insullin-like growth factor (IGF-1) was decreased The given markers can be labeled as potential markers of diagnostic and prognosis of development of retarded consolidation of fractures.

[Reparative osteogenesis after the treatment of multiple fractures of the crural bones using the Ilizarov method]. / Reparativnoe kosteobrazovanie pri lechenii mnozhestvennykh perelomov kostei goleni po metodu Ilizarova.

Repair osteogenesis is associated with a certain pattern of change in bone tissue metabolism: metabolic processes are first enhanced continuously and, reaching a peak, grow weaker. Radioisotopic evidence demonstrates that osteogenesis is concluded within 7 to 8 weeks where the fractures involve no bone displacement, and 9 to 10 weeks where the bones were displaced by fracture.