[Assessment of dental status, monitoring of individual hygiene and quality of life of patients with jaw defects in combination with medical osteonecrosis]. / Otsenka stomatologicheskogo statusa, kontrolya individual'noi gigieny i kachestva zhizni patsientov s defektami chelyustei v sochetanii s medikamentozno assotsiirovannym osteonekrozom.

THE AIM OF THE STUDY: Was to study the dental status, control individual hygiene and assess the quality of life of patients with jaw defects in combination with medical osteonecrosis at the stages of orthopedic rehabilitation. MATERIALS AND METHODS: 38 patients were examined, divided into two groups of 19 people aged 49 to 74 years (average age - 61.5±4.25 years). The main group was comprised of patients after resection of the jaws for malignant neoplasms. The comparison group consisted of patients with partial tooth loss who do not have a history of cancer. All participants used individual hygiene products in the form of parodontax Complete protection toothpaste and parodontax Extra 0.2% mouthwash, along with dental prosthetics, according to a certain scheme. The analysis was performed at the beginning of the study, after 7, 14 days and 2 months. The results of prosthetics and the quality of life of patients in both groups were evaluated using a questionnaire developed by us, which allows us to evaluate various parameters (pain, functions, sensations, social activity). RESULTS: The dynamics of the values of the hygiene index, bleeding gums and qualitative analysis of mixed saliva confirm the positive effect of regular use of recommended hygiene products on the oral tissue. There was an increase in the number of buccal epithelial cells with a low degree of destruction, which indicates the restoration of the barrier properties of the epithelial layer. The orthopedic rehabilitation performed against the background of the use of personal hygiene products showed a positive dynamics of all the studied parameters. After applying prosthetics, patients in the control group noted the restoration of chewing and speech, improved appearance and mood. CONCLUSION: Orthopedic treatment of patients after jaw resection in combination with the complex use of PO and OP allows to solve the issue of their functional, cosmetic and social rehabilitation.

[The first experience of PD-L1 testing of triple negative breast cancer with marker SP142 in Russia]. / Pervyi opyt PD-L1-testirovaniya troinogo negativnogo raka molochnoi zhelezy markerom SP142 v Rossii.

AIM OF STUDY: To evaluate the pecularities of PD-L1 expression in triple negative breast cancer (TNBC) in the Russian population. MATERIALS AND METHODS: For 7 months, within a scientific study of the Russian Society of Clinical Oncology (RUSSCO), we determined the PD-L1 status of 58 patients with TNBC. In each case, an immunohistochemical study was performed in a closed Ventana Bench Mark Ultra automatic stainer using a closed protocol with rabbit monoclonal antibodies Ventana PD-L1 SP142 and Opti View DAB IHC Detection Kit with Opti View Amplification Kit. RESULTS: Positive PD-L1 status in TNBC was detected in 37.93% of cases. Almost all tumors had an expression level of up to 10%. Only 5.17% of cases showed ligand expression on tumor cells. CONCLUSIONS: According to the results of the first experience of testing PD-L1 in TNLM in Russia, it was possible to obtain data comparable to the same data of large international studies. RUSSCO's information and logistic support allows making this analysis available to all citizens of the country.

[The efficacy of polychemotherapy with cisplatin, methotrexate and 5-fluorouracil in inoperable forms of squamous cell cancer of the head and neck area]. / Effektivnost' polikhimioterapii tsisplatinom, metotreksatom i 5-ftoruratsilom pri neoperabel'nykh formakh ploskokletochnogo raka oblasti golovy i shei.

The results of treatment of 19 cases of inoperable squamous cell tumors of the head and neck are discussed. The treatment schedule used three drugs: 100 mg/m2 cisplatin at day 1, 25 mg/m2 methotrexate, intravenously, at day 4, and a total of 1000 mg/m2 5-fluorouracil, at days 4-8 of treatment, by continuous 120 hour-long infusion. Effect was observed in 15 patients. The treatment was effective in 47.4% (complete regression--in 1 case, morphologically confirmed and partial regression--in 8 cases), stabilization--in 26.3 (5 patients) and further progression--in 26.3% (5 patients). Among the untoward side-effects were nausea, vomiting, anorexia, stomatitis and diarrhea. The toxicity proved tolerable.

[Combined treatment of patients with metastases of skin melanoma using cryotherapy]. / Kompleksnoe lechenie bol'nykh s metastazami melanomy kozhi s ispol'zovaniem krioterapii.

Cryotherapy or cryotherapy plus intratumoral injection of BCG vaccine were used in combination with either prospidin or imidazole-carboxamide and multidrug chemotherapy including vincristine, dactinomycin and CCNU for the treatment of 106 cases of cutaneous and subcutaneous metastases of skin malignant melanoma. Five-year survival for the entire group was 36 +/- 5.1%. The best results were obtained for prospidin (43.6 +/- 8.6%) (imidazole-carboxamide--31.3 +/- 9.4% and combined chemotherapy--30.5 +/- 5.8%). Imidazole-carboxamide should be used in conjunction with cryotherapy plus intratumoral BCG vaccine. Procedure of topical treatment did not significantly influence the effectiveness of prospidin or combination chemotherapy.