[Prevention of experimental allergic encephalomyelitis in guinea pigs by treatment with magnetophores]. / Predotvrashchenie éksperimental'nogo allergicheskogo éntsefalomielita u morskikh svinok vozdeistviem magnitoforov.

Subcutaneous application of magnetophores with a field intensity of 210 ersted prevented the development of experimental allergic encephalomyelitis (EAE) in guinea-pigs. The magnetophores appeared efficacious both at the beginning of the induction period and in the second half of the latent period, i.e. within the first two weeks after injection of encephalitogenic suspension. Application of magnetophores after the appearance of the neurological signs of EAE was ineffective. Magnetophores did not affect cellular or humoral response in animals. It may be assumed that the effect of magnetophores is related to the increased resistance of nerve cells to the immunopathological action of the immune response factors, a topic for further studies.

[Suppressive effect of normal lymphoid cells on manifestations of immunologic memory]. / Supressornoe deistvie normal'nykh limfoidnykh kletok na proiavleniia immunologicheskoi pamiati.

The authors studied the influence of the cells of normal lymphoid organs on the level of immunological response in the recipients of splenic cells from the suppressed animals. The organ cells were mixed with the suppressed ones and were administered to the recipients together with the reimmunizing dose of the antigen. Cells of the spleen, of the lymph nodes, the thymus or of the bone marrow suppressed the capacity of the memory cells to the realization of the immunological response to sheep red blood cells and egg albumin. The spleen cells of one and a half month old mice were more active than the cells of young or old animals. The suppressor activity persisted after the administration to donors of various doses of cortisone or heating of the cells transferred at 56 degrees C. Treatment with T-antiserum or heating at 80 degrees C led to reduction of the suppressor action of normal cells.

[Natural immune response and immunological memory in the effects of a 2d unrelated antigen]. / Zakonomernosti immunnogo otveta i immunologicheskoi pamiati pri deistvii vtorogo nerodstvennogo antigena

In combined administration of two nonaffiliated erythrocytic antigens there can be seen both depression and stimulation of the immunological response to the participating antigens. The end result of the interaction depended on the "power", the dose and the order of administration of the antigens. Distribution of the antigen in the animals whose immune response was depressed as a result of preliminary administration of the nonaffiliated antigen remained unchanged. The factor determining the effect on the immunological response to the other antigen did not serve as an antibody.