RESUMO
The effect of 25, 50 and 75 mg/kg body wt. chlordane on the blood glucose level and of glucose administration in chlordane intoxicated Indian desert gerbils are investigated. Chlordane produces hyperglycemia and lowers the glucose tolerance indicating an impairment in the uptake and utilization of glucose in intoxicated gerbils. The possible reasons for these effects are discussed.
Assuntos
Glicemia/metabolismo , Clordano/farmacologia , Glucose/farmacologia , Animais , Clordano/toxicidade , Gerbillinae , Teste de Tolerância a Glucose , Masculino , Fatores de TempoRESUMO
Different acute doses of chlordane enhance the serum alkaline phosphatase activity in Indian desert gerbils. The damage to parenchymal cells of liver, and hepatic microsomal enzyme induction as a result of chlordane treatment are discussed as the possible reasons for the increase in serum alkaline phosphatase activity.
Assuntos
Fosfatase Alcalina/sangue , Clordano/toxicidade , Animais , Gerbillinae , Masculino , Fatores de TempoAssuntos
Proteínas Sanguíneas/metabolismo , Clordano/farmacologia , Animais , Gerbillinae , MasculinoRESUMO
The effect of different doses of pyrethrum on the blood glucose level and glucose tolerance in pytethrum-administered gerbils, were investigated. Pyrethrum produces hyperglycemia and lowers the glucose tolerance indicating an impairment in the uptake and utilization of glucose. The possible reasons for these effects are discussed.