The effect of the scanning pathway in high-intensity focused ultrasound therapy on lesion production.

Because tumors are much larger in size compared with the beam width of high-intensity focused ultrasound (HIFU), raster scanning throughout the entire target is conventionally performed for HIFU thermal ablation. Thermal diffusion affects the temperature elevation and the consequent lesion formation. As a result, the lesion will grow continuously over the course of HIFU therapy. The purpose of this study was to investigate the influence of scanning pathways on the overall thermal lesion. Two new scanning pathways, spiral scanning from the center to the outside and spiral scanning from the outside to the center, were proposed with the same HIFU parameters (power and exposure time) for each treatment spot. The lesions produced in the gel phantom and bovine liver were compared with those using raster scanning. Although more uniform lesions can be achieved using the new scanning pathways, the produced lesion areas (27.5 ± 12.3 mm(2) and 65.2 ± 9.6 mm(2), respectively) in the gel phantom are significantly smaller (p < 0.05) than those using raster scanning (92.9 ± 11.8 mm(2)). Furthermore, the lesion patterns in the gel phantom and bovine liver were similar to the simulations using temperature and thermal dose-threshold models, respectively. Thermal diffusion, the scanning pathway and the biophysical aspects of the target all play important roles in HIFU lesion production. By selecting the appropriate scanning pathway and varying the parameters as ablation progresses, HIFU therapy can achieve uniform lesions while minimizing the total delivered energy and treatment time.

Acoustic scattering from a solid aluminum cylinder in contact with a sand sediment: measurements, modeling, and interpretation.

Understanding acoustic scattering from objects placed on the interface between two media requires incorporation of scattering off the interface. Here, this class of problems is studied in the particular context of a 61 cm long, 30.5 cm diameter solid aluminum cylinder placed on a flattened sand interface. Experimental results are presented for the monostatic scattering from this cylinder for azimuthal scattering angles from 0 degrees to 90 degrees and frequencies from 1 to 30 kHz. In addition, synthetic aperture sonar (SAS) processing is carried out. Next, details seen within these experimental results are explained using insight derived from physical acoustics. Subsequently, target strength results are compared to finite-element (FE) calculations. The simplest calculation assumes that the source and receiver are at infinity and uses the FE result for the cylinder in free space along with image cylinders for approximating the target/interface interaction. Then the effect of finite geometries and inclusion of a more complete Green's function for the target/interface interaction is examined. These first two calculations use the axial symmetry of the cylinder in carrying out the analysis. Finally, the results from a three dimensional FE analysis are presented and compared to both the experiment and the axially symmetric calculations.

Effective medium approach to linear acoustics in bubbly liquids.

Linear wave propagation through a bubbly liquid has seen a resurgence of interest because of proposed "corrections" to the lowest-order approximation of an effective wave number obtained from Foldy's exact multiple scattering theory [Foldy, Phys. Rev. 67, 107 (1945)]. An alternative approach to wave propagation through a bubbly liquid reduces the governing equations for a two-phase medium to an effective medium. Based on this approach, Commander and Prosperetti [J. Acoust. Soc. Am. 85, 732 (1989)] derive an expression for the lowest-order approximation to an effective wave number. At this level of approximation the bubbles interact with only the mean acoustic field without higher-order rescattering. That is, the field scattered from a bubble may interact with one or more new bubbles in the distribution, but a portion of that scattered field may not be scattered back to any previous bubble. The current article shows that modifications to the results of Commander and Prosperetti lead to a new expression for the effective wave number, which properly accounts for all higher orders of multiple scattering.