[Evaluation of NMR relaxation method as a diagnostic tool for donor blood analysis and patients with hematologic diseases and burns]. / Otsenka diagnosticheskikh vozmozhnostei metoda IaMR-relaksatsii pri analize krovi donorov, gematologicheskikh i ozhogovykh bol'nykh.

Diagnostic value of the NMR-relaxation method in the blood plasma was estimated in the patients with different pathologies. The time of hydrogen nuclei longitudinal relaxation (T1) in the health donors of the blood, in the patients with oncopathology (hemoblastoses) and in the cases with anemia and burning disease were investigated. The time of the longitudinal relaxation (T1) was measured by automated NMR-relaxometer "Palma" (Russia). The working frequency was equal to 35 MHz, the temperature was 45 +/- 0.1 degrees C. For the single measurement 0.2 ml of blood obtained from heparinized venous blood 1.5 hours after its taking was used. The time of the longitudinal relaxation (T1) was shown to be 1.78 +/- 0.02 in the health donors, 1.70 +/- 0.06 s in cases with anemia, 1.97 +/- 0.48 c in patients with leucosis, 2.40 +/- 0.12 s in patients with burns. The sensitivity and the specificity of diagnostics of leucosis based upon the results of the only single T1 measurement in blood plasma were concluded to be 75%. It proves the significant T1 change both in patients with anemia and burning disease of the II-III degree. However it is evidently insufficient for selective use of NMR-relaxation blood plasma (serum) in the diagnostics of anemia and leucosis. The data obtained prove also the possibility of use of NMR-relaxation blood plasma (serum) for control of the hemostasis state during treatment or remission.

[Magnetic resonance characteristics of the blood serum of healthy persons]. / Magnitno-rezonansnye kharakteristiki syvorotki krovi zdorovykh liudei.

A study was made of the time spin-grid T1 and spin-spin T2 of NMR-relaxation of the blood serum of healthy individuals. These parameters were shown not to depend on age and sex but to differ from such parameters in patients, especially cancer patients.

[NMR-relaxation of blood serum in cancer patients]. / IaMR-relaksatsiia syvorotki krovi onkologicheskikh bol'nykh.

A study was made of the levels of T1 and T2 of NMR-relaxation of the blood serum of 197 healthy person, 180 patients without a history of malignant tumors and in 345 cancer patients with tumors of different sites. The above parameters did not depend on the patients' sex and age. T1 and T2 values in the cancer patients were much higher than in the patients without tumors and still much higher than in the healthy subjects, and depended on tumor spreading and site. The above values could be probably used for the control of therapeutic efficacy in cancer patients.