[Effect of treatment with perftoran on the course of experimental uveitis, lipid peroxidation and activity of antioxidant defense enzymes]. / Techenie éksperimental'nogo uveita, protsessy perekisnogo okisleniia lipidov i aktivnost' fermentov antioksidantnoi zashchity na fone lecheniia perftoranom.

Experimental uveitis is characterized by a pronounced lipid peroxidation (LPO) in damaged tissues of eye, which is complicated by reduced activity of the antioxidant enzymes, SOD and catalase. The intensification of LPO was also found in blood serum and hepatic tissue. However, hepatic lipid peroxidation was accompanied by compensatory increase of catalase activity. The activity of antioxidant defence enzymes decreased in blood, whereas catalase was activated in hepatic tissue. The therapeutic effect was accompanied by a decrease of LPO products and increase of activity of the antioxidant enzymes in all tissues. Treatment of uveitis with gentamycin and, especially, perftoran reduced inflammatory events.

[Disturbance in immunlogic reactivity in rats with uveitis dependeing on the intensity of acetylation processes]. / Narusheniia immunologicheskoi reaktivnosti u krys s uveitom v zavisimosti ot intensivnosti protsessov atsetilirovaniia.

In females and males with uveitis, a similar picture was to be seen of changes in indices for the titre of antibodies in the peripheral blood. It could be summarized that a more profound immunodeficiency in those specimens demonstrating elevated parameters for acetylation is associated with a stronger impact of products of the inflammatory reaction in the eye to immunocompetent cells. But more in-depth research is needed into this question to resolve it.

[Effect of bacteriophage on the lipid peroxidation process and antioxidant protective enzymes in experimental uveitis]. / Vliianie bakteriofaga na protsessy perekisnogo okisleniia lipidov i aktivnost' fermentov antioksidantnoi zashchity pri éksperimental'nom uveite.

Experimental uveitis features distinct hyperlipoperoxidation in damaged eye tissues, blood serum and the liver. The activity of antioxidant defense (AOD) enzymes decreases in tissues and blood of experimental animals whereas catalase compensatorily activates in hepatic tissue. Experimental therapy of uveitis with gentamycin and bacteriophage results in reducing hyperlipoperoxidation, increased activity of AOD enzymes but no complete normalization is observed. This manifested in preservation of inflammations to a certain degree.

[Effect of veroshpiron on hormone level in patients with Parkinson's disease]. / Vliianie veroshpirona na gormonalnyi profil u bolnykh Parkinsonizmom.

Blood hormones and urinary excretion of corticosteroids were measured in 39 parkinsonian patients receiving chemotherapy with adjuvant 3-week course of verospiron (50-100 mg/day). The latter promoted normalization of endocrine and clinical statuses in the majority of the patients. It is suggested that the response may be obtained via neuropeptide systems of the brain.

[A comparative study of the catecholamine content of the blood and urine in patients with facial paraspasm (Meige's syndrome)]. / Sravnitel'noe issledovanie soderzhaniia katekholaminov v krovi i moche u bol'nykh s litsevym paraspazom (sindrom Mezha).

Catecholamines and DOPA excretion and televant levels in blood were measured in 17 patients with facial paraspasm and in 24 healthy subjects. The findings gave evidence for sympathetic-adrenal system adrenal activation and more intensive catecholamine metabolism in patients, especially marked in those with generalised facial hyperkinesia.

[The characteristics of catecholamine excretion in parkinsonism patients in effective treatment and therapeutic resistance]. / Osobennosti ékskretsii katekholaminov u bol'nykh parkinsonizmom pri éffektivnom lechenii i terapevticheskoi rezistentnosti.

Catecholamines excretion has been analyzed in 36 patients suffering from parkinsonism and in 30 normal subjects. Curable patients demonstrated the same proportion of epinephrine and norepinephrine/DOPA excretion as normal subjects did. In resistant to treatment subjects and in unlikely curable the above coefficients were significantly larger. It is suggested that enhanced activity of peripheral sympathoadrenal system may serve a factor of low response to medication.

[Correlation of clinico-physiologic indices and the serotonin content of the blood of patients with parkinsonism]. / Korreliatsiia kliniko-fiziologicheskikh pokazatelei i soderzhaniia serotonina v krovi u bol'nykh parkinsonizmom.

On withdrawal of L-DOPA-containing drugs the blood serotonin content decreased in parkinsonism patients irrespective of form and etiology of the disease. L-DOPA-containing drugs caused the blood serotonin levels to rise. Substantial correlations of the blood serotonin levels and clinico-physiologic indices were found mostly in postencephalitic parkinsonism.

[Experience using veroshpiron in the combined therapy of parkinsonism]. / Opyt primeneniia veroshpirona v kompleksnoi terapii parkinsonizma.

The authors found changes in the function of the adrenals in parkinsonism, which were expressed in the form of elevated excretion of aldosterone and diminished excretion of hydrocortisone. The use of veroshpiron led to a certain normalization of adrenal function and to activation of the sympatho-adrenal system. The study of the clinical efficacy of veroshpiron administered for 20 days in a daily dose of 50-100 mg to 56 patients with parkinsonism showed improvement of a varying degree in 87.5% of patients. A 20-day course of veroshpiron resulted in regression of approximately 1/3 of the main symptoms of parkinsonism with the improvement persisting for several months.

[Changes in the blood level of serotonin in Parkinson disease]. / Izmeneniia soderzhaniia serotonina v krovi pri parkinsonizme.

Content of serotonin was studied in blood of 81 patient with parkinsonism and of 31 practically healthy person. Content of serotonin was distinctly decreased in blood of the patients with parkinsonism. With ageing concentration of the amine was increased in blood of the patients and decreased in control group.

[Function of the adrenal medullary layer in rats with experimental alloxan diabetes]. / Funktsional'noe sostoianie mozgovogo sloia nadpochechnikov u krys s éksperimental'nym alloksanovym sakharnym diabetom.

The level of catecholamines in the adrenals and catecholamine synthesis during incubation of adrenal slices in the presence of L-tyrosine were investigated in rats with alloxan diabetes mellitus. Experiments were conducted in 2 groups of rats with experimental diabetes mellitus: intact animals and those subjected to immobilization for 1 h. The results were compared with those of the investigation of 2 similar groups of control animals. In experimental alloxan diabetes the concentration of adrenaline in the adrenals was lowered. An increase in the adrenaline level in the incubation medium was noted in the control group of rats subjected to immobilization, and in the group of intact diabetic animals. No significant rise of adrenaline secretion was observed in diabetic animals subjected to immobilization.