[Methods for evaluating the economic efficiency of the project of PET-center's creation in conditions of a specialized medical institution].

This study evaluates the cost-effectiveness of the project of PET center's creation in the structure of specialized institution. To analyze the effectiveness and stability of obtained results there are used estimations of discounted factors, the flow and the amount of investments and the income at different discount rates. The figures revealed that the project should generate revenue as at zero discount rate it pays off.

[Creation of a statistical model for prediction of Hodgkin's lymphoma in young adults].

The aim of this study was to create a multi-dimensional correlation matrix of determinants giving information on the degree of influence on survival of young adults with Hodgkin's lymphoma each variable as well as the effect of the interaction of these variables with each other. 87 patients with Hodgkin's lymphoma at the age of 19 to 29 years (mean age 24 ± 4 years) were included in the study. Multiple matrix containing the coefficients of correlation of survival and correlation coefficients of 35 analyzed factors was of 5 significant determinants (volume of tumor lesion, stage IV of disease, E-damage, accelerated erythrocyte sedimentation rate, leukocytosis). Construction of the correlation matrix in order to select factors to be included in the equation, which contained the pair correlation coefficients of overall survival and each of factors, showed that only the volume of tumor lesion (correlation coefficient 0.2570, p = 0.026) influences on sign-result. Multiple regression equation is represented as follows ȳ=0,166667-0,227273x[volume]; R2=0,0643674507. This equation allows for given values of the factor «volume of tumor lesion" to have theoretical values of resultant sign (survival), substituting the actual values of the factor in it.

[Anxiety disorders diagnostic algorithm in cancer patients].

The article defines the basic principles of anxiety disorders diagnosis (anxious-phobic disorders, panic disorder, generalized anxiety disorder) in cancer patients in accordance with the evidence-based medicine. There are provided typical clinical manifestations, features and variants of courses of disease. There is proposed the anxiety-phobic disorders diagnosis algorithm. There are characterized clinical, experimental, psychological, laboratory methods and are highlighted stages of diagnostic process.

[Rehabilitation of cancer patients as a basis for improving the quality of life].

Rehabilitation of a cancer patient should be aimed not only at eliminating the disease itself and restore natural functions of the body but also at the maximum acceptable recovery of the human abilities to live with the disease and after it. Rehabilitation is carried out by efforts various professionals who in their work should take into account the state of a cancer patient and the features of his personality. Rehabilitation is one of factors in improving the quality of life of cancer patients.

[Optimization of pharmacological therapy for weakness syndrome in incurable patients].

In this work there is considered the possibility of correction of therapy for weakness syndrome in incurable patients with the use of drugs affecting dopamine and serotonin exchanges. It is showed that the use of 100 mg of ladasten, 16 mg of ondansetron orally per day and 50 mg of agomelatine per night is more effective in therapy for fatigue/weakness syndrome in incurable cancer patients compared to standard therapy.

[Predictive value of Hodgkin's lymphoma tumor burden in present].

Today approximately 70% of patients with Hodgkin lymphoma can be cured with the combined-modality therapy. Tumor burden, the importance of which was demonstrated 15 years ago for the first time, is a powerful prognostic factor. Data of literature of representations on predictive value of Hodgkin's lymphoma tumor burden are shown in the article. The difficult immunological relations between tumor cells and reactive ones lead to development of the main symptoms. Nevertheless, the collective sign of tumor burden shows the greatest influence on survival and on probability of resistance, which relative risk can be predicted on this variable and treatment program. Patients with bulky disease need escalated therapy with high-dose chemotherapy. Integration into predictive models of the variable will change an expected contribution of clinical and laboratory parameters in the regression analyses constructed on patients with Hodgkin's lymphoma. Today the role of diagnostic functional methods, in particular a positron emission tomography, for metabolic active measurement is conducted which allows excluding a reactive component.