[Treatment of diaphyseal femoral fractures with extramedullary compressive-dynamic osteosynthesis].

Since 2000 year 39 patients with diaphyseal femoral fractures have been treated using the technique of extramedullary compressive-dynamic osteosynthesis. Treatment is finished in 25 patients, 11 of them resumed their previous activities, while 14 did not. They are under follow-up and demonstrate different stages of fracture consolidation. The constructed device meets the requirements of extramedullary fixation and develops the necessary compression of the fracture zone. The flexible partly transfers the load to the fracture area, stimulating, thus, regeneration and consolidation of the lesion.

[Spectrum, incidence and prognostic value of systemic manifestations in chronic hepatitis C of low activity].

AIM: To study the incidence and prognostic significance of extrahepatic manifestations of chronic HCV-infection with low activity of hepatic process and to specify treatment policy. MATERIAL AND METHODS: Sixty-two patients with low-active chronic hepatitis C (CHC) entered the study. Blood samples from all the patients were studied clinically, biochemically, immunologically and virusologically. In 58 patients the diagnosis was confirmed morphologically (liver tissue). RESULTS: Systemic manifestations of CHC were observed in 23 (37.1%) patients, in 12 of them they were associated with cryoglobulinemia. Most frequent was cryoglobulinemic vasculitis with skin (12.9%) and joint (9.7%) involvement, cryoglobulinemic glomerulonephritis (11.3%), arthralgia without association with cryoglobulinemia (11.3%). Independent risk factors for development of systemic disorders in CHC of low activity comprised female gender, age over 45, the disease duration and presence of cryoglobulinemia. CONCLUSION: CHC of low activity is characterized by high occurrence of systemic manifestations primarily associated with cryoglobulinemia. Renal affection with development of cryoglobulinemic glomerulonephritis is most prognostically significant.