[Postirradiated mice volatile secretion, irradiated in the lethal and superlethal dose].

In the early period after exposure to the radiation in the lethal dose (10 Gy) mice secreted with urine the volatile components, that attract for intact individuals. In the late period appear components with aversive property. In the terminal period after exposure to superlethal dose (70 Gy) dominate the secretions with aversive property. The exposure of intact recipients with the volatile secretions attractive or aversive in equal degree depression result in suppression their ability to the humoral immune response.

[The influence of postradiation chemical signals of mice on the humoral immune response in recipients in different time relative to antigenic stimulus].

The influence of volatile urine chemosignals of irradiated (4 Gy) mice on the primary humoral immune response to sheep red blood cells in intact recipients was investigated. It was demonstrated that the direction of immunomodulatory effect is dependent upon the time at which the postradiation chemosignals was initially applied. The antibody response to antigen was markedly suppressed in mice that were exposed before antigen injection. When chemosignals applied immediately following inoculation of antigen the antibody response was unaffected. The immune response was increased when chemosignals was loadeded for 1-10 days after immunization. The possible mechanisms of immunomodulation are considered.

[Poststressor change in attractiveness of mice odourgens].

It was shown, that under physiological conditions, intact noninbred mice or high-inbred mice-testers in reaction of preference-avoidance prefer volatile components secreted by mice of a genetically identical group. After exposure to stress factors, mice release with urine the volatile components, which are more preferable by testers than the volatile secretion of intact mice indepedently of the genotype of mice.

[Post-stress state and communicative alterations of immunity and blood]. / Poststressornye sostoianiia i kommunikativnye narusheniia immuniteta i krovi.

It is shown that intact animals caged with stressed animals or in smell contact with natural secretions of stressed animals develop alterations of the immune system and peripheral blood cell composition. The decline in the genesis of antibodies to T-dependent antigen is related to the animals' gender and occurs at the height of poststress immunodepression.

[Post-radiation communicative induction of blood and immunity disorders]. / Postradiatsionnaia kommunikativnaia induktsiia narushenii krovi i immuniteta.

Intact rats and mice were kept in one cage with irradiated rats and mice. Measurements of leukocyte and nuclear neutrophils counts in the peripheral blood, weight of the thymus and immune reactivity int he intact animals indicated that 1-2 weeks of sharing cage with irradiated animals produced a fall in the above values compared to those of the controls. This seems to be a reaction to changed behavior of the irradiated animals. The intact ones experienced anxiety which may provoke the above disorders.

[Natural excretions of mice in the postradiation period and contact induction of immunodeficiencies]. / Estestvennye vydeleniia myshei v postradiatsionnom periode i kontaktnaia induktsiia immunodefitsitov.

It was showed that the daily transfer of natural secrets litter from irradiated mice to intact mice decreased parameters of intact mice immune reactivity in 14 days. Presumedly this effect, conditioned of pathological odours, discovered on one from mechanism of contact induction second immunodeficient, also caged intact with irradiated animals.

[Effects of stress at different times after irradiation on capacity of humoral immune response in mice]. / Vliianie stressa v raznye sroki posle oblucheniia na sposobnost' k gumoral'nomu immunnomu otvetu u myshei.

It was shown, that sensitivity of immune response to stress in postirradiated period essentially depends from the dose of irradiation (1, 2 Gy) and the period after irradiation. The sensitivity was not distinguished from intact mice in early period further the sensitivity of immune response can be increased (1 Gy) or can be decreased (2 Gy), stress can be stimulated of the antibody-formation to sheep red blood cells in late period after irradiation.

[Communicative behavioral effects and disorders of immunity]. / Kommunikativnye povedencheskie éffekty i narusheniia immuniteta.

Rats and mice subjected to stress and/or irradiation or their urine induce impairment or the indices of immunologic reactivity in caged together their intact mates. It is suggested that communicative behavior, including olfactory-odor components, affect the state of blood and immunity systems.

[The combined action of ionizing radiation and stress on antibody formation in mice]. / Sochetannoe vozdeistvie ioniziruiushchei radiatsii i stressa na antitelogenez u myshei.

Disturbances in humoral immune response to sheep erythrocytes after separate and combined effect of ionizing radiation (2 and 4 Gy) and stress (swimming for 10 of 60 min) was studied in mice. The increase in sensitivity to stress was found in irradiated mice. Superposition of undulating dynamics of post-stress immunosuppression on dynamics of post-radiation disorder was revealed. This is due to the different mechanisms of disturbances: redistribution of precursors of immunocompetent cells between immune organs in the first case and destruction of cells in the second case.

[Immunopharmacological analysis of secondary postradiation immunodeficiency]. / Immunofarmakologicheskii analiz vtorichnogo postluchevogo immunodefitsita.

A model for secondary postradiation immunodeficiency of mice has been used to compare immunocorrective activities of some new immunomodulators (arbidol, cagocel, myelopid, proleukinferon and fragmine) administered at late times (2-3 months) after exposure to a nonlethal radiation dose (4.0 Gy). The highest immunocorrective effect has been shown with fragmine and proleukinferon.

Congenital pulmonary arteriovenous aneurysms.

The authors analyse their diagnostic and therapeutic experience with 26 patients suffering from congenital pulmonary arteriovenous aneurysms. Symptoms of the disease were found to depend directly on the presence and volume of arterial blood shunted into the venous bed. The volume of shunted nonoxygenated blood varied between 20 and 48 p.c.; the reflux caused hypoxic hypoxaemia with HbO2art. = 91.2 +/- 1.43%; pO2art. = 63.6 +/- 5.54 mmHg. Aimed tomography and pulmonary angiography proved most advantageous in terms of diagnostic; with their aid it was possible to identify three variants of congenital pulmonary arteriovenous aneurysm: isolated, multiple and "of the capillary haemangioma type".

[Surgical correction of congenital arteriovenous aneurysms of the lungs]. / Khirurgicheskaia korrektsiia vrozhdennykh arteriovenoznykh anevrizm legkikh.

The authors have analyzed results of the surgical treatment of 24 out of 26 patients observed at the clinic for arterio-venous aneurysms of the lungs. It was found that the reduction of efficiency of the gas exchange function of the lungs before operation manifested itself by arterial and venous hypoxemia with an increased arterio-venous oxygen difference and pronounced decrease of blood oxygen strain. Good results of the operative treatment, rapid recovery of blood oxygenation, disappearance of hypoxemia symptoms make the surgical method the only radical one in treatment of such patients. The operation of choice was lobectomy. No lethal outcomes followed.