Predicting aging transition using Echo state network.

It is generally known that in a mixture of coupled active and inactive nonlinear oscillators, the entire system may stop oscillating and become inactive if the fraction of active oscillators is reduced to a critical value. This emerging phenomenon, called the "aging transition," can be analytically predicted from the view point of cluster synchronization. One can question whether a model-free, data-driven framework based on neural networks could be used to foretell when such a system will cease oscillation. Here, we demonstrate how a straightforward ESN with trained output weights can accurately forecast both the temporal evaluation and the onset of collapse in coupled paradigmatic limit-cycle oscillators. In particular, we have demonstrated that an ESN can identify the critical fraction of inactive oscillators in a large all-to-all, small-world, and scale-free network when it is trained only with two nodes (one active and the other inactive) selected from three different pre-collapse regimes. We further demonstrate that ESN can anticipate aging transition of the network when trained with the mean-field dynamics of active and inactive oscillators.

Quetiapine-induced Diabetic Ketoacidosis.

Psychomotor retardation and extrapyramidal symptoms have limited the conventional antipsychotic use. Atypical antipsychotics though widely prescribed with good tolerability and efficacy, the metabolic complications associated with them are of clinical importance. Diabetic ketoacidosis (DKA) is a fatal complication of atypical antipsychotic use. We report a case of new-onset diabetes presenting as DKA with quetiapine use.

Factitious Disorder - A Rare Cause for Unexplained Epistaxis.

Epistaxis or nasal bleeding is a common condition which may be severe enough to warrant an urgent medical or surgical treatment. Factitious epistaxis is a rare entity. Due to a lack of exposure in complex behavioral issues during undergraduate training, it is quite natural on the part of a surgeon to miss the underlying emotional phenomena. Here, we present a case of factitious disorder which presented to the surgical causality with nasal bleeding. After proper evaluation and liaison with the department of otorhinolaryngology, we were able to manage the patient with antidepressants and cognitive behavioral therapy.

Arachnoid Cyst and Psychosis: The Troublemaker or Innocent Bystander.

Organic underpinning of a psychotic disturbance is often missed. Arachnoid cysts are considered a rare neurological tumor, few of which exhibit any symptomatology. In most cases, they are diagnosed by accident. Literature regarding the coexistence of arachnoid cysts with psychiatric disorders is sparse. Here, we present a case who presented with a typical presentation of psychosis which was not enough for suspecting for an organic etiology.

Psychosis in Secondary Empty Sella Syndrome following a Russell's Viper Bite.

Hypopituitarism can present with psychiatric symptoms. We report a unique case of psychosis in clear consciousness in a case of hypopituitarism due to the secondary empty sella syndrome following a Russell's viper bite which was untreated and presented with psychotic symptoms for past 13 years following the snake bite. After the diagnosis of psychosis due to hypopituitarism was made, the patient was treated with levothyroxine and prednisolone supplements and his psychotic symptoms subsided without any psychotropic drugs. Vasculotoxic snake bites can cause hypopituitarism and can present with psychosis. Further research will be needed into the prevalence of this phenomenon.

Long-term Follow-up of a Case of Gilles de la Tourette's syndrome.

Gilles de la Tourette's syndrome is a combined vocal and multiple motor tic disorder. Here, we present a case of Tourette's syndrome who attended our psychiatric causality with severe depression and suicidal ideation. On reviewing follow-up records of 23 years, we come to know about the academic decline and nicotine dependence in the early childhood. He also developed co-morbid obsessive compulsive disorder (OCD) along with severe depression. He was agitated and self-injurious. We diagnosed him as Gilles de la Tourette's syndrome with co-morbid OCD, depression, nicotine dependence. The patient was treated with haloperidol, sertraline, and clonidine when he developed mixed switch that necessitated us to stop sertraline. Hence, he was treated with a mood stabilizer and he remitted. Here, we want to show how Tourette's syndrome can take a longer course with different co-morbidities in a single person's life. As per our knowledge, such presentation is relatively rare in Indian literature.