RESUMO
AIM: To examine anti-inflammatory effect of statins on outcomes of acute coronary syndrome (ACS). MATERIAL AND METHODS: The trial included 211 ACS patients without ST elevation at ECG. The patients were followed up for 180 days. The anti-inflammatory action was studied for 30 days. The patients were divided into two groups by the treatment: simvastatin 10 mg + aspirin 325 mg (104 patients, group 1) and simvastatin 40 mg + aspirin 325 mg (107 patients, group 2) for 30 days. RESULTS: Simvastatin in maximal dose lowed LDLP cholesterol from 101 +/- 9.8 to 72 +/- 3.3 mg/dl, in a minimal dose--from 104 +/- 11.3 to 81 +/- 2.1 mg/dl (p < 0.05). Only maximal dose simvastatin produced a significant reduction of C-reactive protein (CRP) to the disease day 14. The integral index including all cases of cardiovascular death +acute myocardial infarction+progressive angina+rehospitalization was 70 scores for group 1 and 137 for group 2 (p = 0.047). CONCLUSION: Use of simvastatin in ACS patients, initially normal level of LDLP cholesterol and elevated level of CRP produced a dose-dependent effect, alleviated inflammation and improved the disease course.
Assuntos
Anti-Inflamatórios/uso terapêutico , LDL-Colesterol/sangue , Doença das Coronárias/tratamento farmacológico , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Sinvastatina/uso terapêutico , Doença Aguda , Idoso , Aspirina/uso terapêutico , Proteína C-Reativa/análise , Quimioterapia Combinada , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Síndrome , Resultado do TratamentoRESUMO
The study was undertaken to examine 89 patients with acute myocardial infarction whose pulmonary pressures were measured under monitoring. The findings were compared with the time course of necrotic focal formation. The rate of the latter was found to determine central hemodynamic changes. High necrotization rates were ascertained to be directly related to the rate of pressure elevation in the pulmonary artery and the changes in stroke volume.
