RESUMO
Motor fluctuations complicate therapy in Parkinson's disease (PD). The mechanisms responsible for motor fluctuations such as the on-off type, are poorly understood. Differences of activity of various enzymes, such as Catechol-O-Methyltransferase (COMT, E.C.2.1.1.6.) may influence the appearance of motor fluctuations and the quantity of metabolic products of levodopa. Aim of this study was to compare erythrocyte COMT-activity in Parkinsonian patients without and with motor fluctuations from the on-off type. No significant differences in COMT-activity appeared in both groups. We conclude that activity differences in COMT-activity do not contribute to the appearance of motor fluctuations in Parkinson's disease.
Assuntos
Catecol O-Metiltransferase/metabolismo , Neurônios Motores/enzimologia , Transtornos dos Movimentos/enzimologia , Doença de Parkinson/enzimologia , Idoso , Progressão da Doença , Ativação Enzimática , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos TestesAssuntos
Doenças do Sistema Nervoso/etiologia , Doenças da Glândula Tireoide/complicações , Idoso , Doenças do Sistema Nervoso Central/etiologia , Ataxia Cerebelar/etiologia , Doenças dos Nervos Cranianos/etiologia , Feminino , Humanos , Hipertireoidismo/complicações , Hipotireoidismo/complicações , Transtornos Mentais/etiologia , Doenças Neuromusculares/etiologia , Doenças do Sistema Nervoso Periférico/etiologiaRESUMO
A case of an idiopathic glossopharyngeal neuralgia associated with an autoimmunological disorder of the thyroid gland is reported here. The relationship between these two diseases is discussed. In conclusion we propose that in all cases of idiopathic glossopharyngeal neuralgia metabolic and autoimmunological disorders of the thyroid should be considered.
