Digital Twin Meets Knowledge Graph for Intelligent Manufacturing Processes.

In the highly competitive field of material manufacturing, stakeholders strive for the increased quality of the end products, reduced cost of operation, and the timely completion of their business processes. Digital twin (DT) technologies are considered major enablers that can be deployed to assist the development and effective provision of manufacturing processes. Additionally, knowledge graphs (KG) have emerged as efficient tools in the industrial domain and are able to efficiently represent data from various disciplines in a structured manner while also supporting advanced analytics. This paper proposes a solution that integrates a KG and DTs. Through this synergy, we aimed to develop highly autonomous and flexible DTs that utilize the semantic knowledge stored in the KG to better support advanced functionalities. The developed KG stores information about materials and their properties and details about the processes in which they are involved, following a flexible schema that is not domain specific. The DT comprises smaller Virtual Objects (VOs), each one acting as an abstraction of a single step of the Industrial Business Process (IBP), providing the necessary functionalities that simulate the corresponding real-world process. By executing appropriate queries to the KG, the DT can orchestrate the operation of the VOs and their physical counterparts and configure their parameters accordingly, in this way increasing its self-awareness. In this article, the architecture of such a solution is presented and its application in a real laser glass bending process is showcased.

Design, Development, and Evaluation of 5G-Enabled Vehicular Services: The 5G-HEART Perspective.

The ongoing transition towards 5G technology expedites the emergence of a variety of mobile applications that pertain to different vertical industries. Delivering on the key commitment of 5G, these diverse service streams, along with their distinct requirements, should be facilitated under the same unified network infrastructure. Consequently, in order to unleash the benefits brought by 5G technology, a holistic approach towards the requirement analysis and the design, development, and evaluation of multiple concurrent vertical services should be followed. In this paper, we focus on the Transport vertical industry, and we study four novel vehicular service categories, each one consisting of one or more related specific scenarios, within the framework of the "5G Health, Aquaculture and Transport (5G-HEART)" 5G PPP ICT-19 (Phase 3) project. In contrast to the majority of the literature, we provide a holistic overview of the overall life-cycle management required for the realization of the examined vehicular use cases. This comprises the definition and analysis of the network Key Performance Indicators (KPIs) resulting from high-level user requirements and their interpretation in terms of the underlying network infrastructure tasked with meeting their conflicting or converging needs. Our approach is complemented by the experimental investigation of the real unified 5G pilot's characteristics that enable the delivery of the considered vehicular services and the initial trialling results that verify the effectiveness and feasibility of the presented theoretical analysis.

ENERDGE: Distributed Energy-Aware Resource Allocation at the Edge.

Mobile applications are progressively becoming more sophisticated and complex, increasing their computational requirements. Traditional offloading approaches that use exclusively the Cloud infrastructure are now deemed unsuitable due to the inherent associated delay. Edge Computing can address most of the Cloud limitations at the cost of limited available resources. This bottleneck necessitates an efficient allocation of offloaded tasks from the mobile devices to the Edge. In this paper, we consider a task offloading setting with applications of different characteristics and requirements, and propose an optimal resource allocation framework leveraging the amalgamation of the edge resources. To balance the trade-off between retaining low total energy consumption, respecting end-to-end delay requirements and load balancing at the Edge, we additionally introduce a Markov Random Field based mechanism for the distribution of the excess workload. The proposed approach investigates a realistic scenario, including different categories of mobile applications, edge devices with different computational capabilities, and dynamic wireless conditions modeled by the dynamic behavior and mobility of the users. The framework is complemented with a prediction mechanism that facilitates the orchestration of the physical resources. The efficiency of the proposed scheme is evaluated via modeling and simulation and is shown to outperform a well-known task offloading solution, as well as a more recent one.

Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer's Disease.

The treatment of complex and multifactorial diseases constitutes a big challenge in day-to-day clinical practice. As many parameters influence clinical phenotypes, accurate diagnosis and prompt therapeutic management is often difficult. Significant research and investment focuses on state-of-the-art genomic and metagenomic analyses in the burgeoning field of Precision (or Personalized) Medicine with genome-wide-association-studies (GWAS) helping in this direction by linking patient genotypes at specific polymorphic sites (single-nucleotide polymorphisms, SNPs) to the specific phenotype. The generation of polygenic risk scores (PRSs) is a relatively novel statistical method that associates the collective genotypes at many of a person's SNPs to a trait or disease. As GWAS sample sizes increase, PRSs may become a powerful tool for prevention, early diagnosis and treatment. However, the complexity and multidimensionality of genetic and environmental contributions to phenotypes continue to pose significant challenges for the clinical, broad-scale use of PRSs. To improve the value of PRS measures, we propose a novel pipeline which might better utilize GWAS results and improve the utility of PRS when applied to Alzheimer's Disease (AD), as a paradigm of multifactorial disease with existing large GWAS datasets that have not yet achieved significant clinical impact. We propose a refined approach for the construction of AD PRS improved by (1), taking into consideration the genetic loci where the SNPs are located, (2) evaluating the post-translational impact of SNPs on coding and non-coding regions by focusing on overlap with open chromatin data and SNPs that are expression quantitative trait loci (QTLs), and (3) scoring and annotating the severity of the associated clinical phenotype into the PRS. Open chromatin and eQTL data need to be carefully selected based on tissue/cell type of origin (e.g., brain, excitatory neurons). Applying such filters to traditional PRS on GWAS studies of complex diseases like AD, can produce a set of SNPs weighted according to our algorithm and a more useful PRS. Our proposed methodology may pave the way for new applications of genomic machine and deep learning pipelines to GWAS datasets in an effort to identify novel clinically useful genetic biomarkers for complex diseases like AD.

Big Data Clustering via Community Detection and Hyperbolic Network Embedding in IoT Applications.

In this paper, we present a novel data clustering framework for big sensory data produced by IoT applications. Based on a network representation of the relations among multi-dimensional data, data clustering is mapped to node clustering over the produced data graphs. To address the potential very large scale of such datasets/graphs that test the limits of state-of-the-art approaches, we map the problem of data clustering to a community detection one over the corresponding data graphs. Specifically, we propose a novel computational approach for enhancing the traditional Girvan-Newman (GN) community detection algorithm via hyperbolic network embedding. The data dependency graph is embedded in the hyperbolic space via Rigel embedding, allowing more efficient computation of edge-betweenness centrality needed in the GN algorithm. This allows for more efficient clustering of the nodes of the data graph in terms of modularity, without sacrificing considerable accuracy. In order to study the operation of our approach with respect to enhancing GN community detection, we employ various representative types of artificial complex networks, such as scale-free, small-world and random geometric topologies, and frequently-employed benchmark datasets for demonstrating its efficacy in terms of data clustering via community detection. Furthermore, we provide a proof-of-concept evaluation by applying the proposed framework over multi-dimensional datasets obtained from an operational smart-city/building IoT infrastructure provided by the Federated Interoperable Semantic IoT/cloud Testbeds and Applications (FIESTA-IoT) testbed federation. It is shown that the proposed framework can be indeed used for community detection/data clustering and exploited in various other IoT applications, such as performing more energy-efficient smart-city/building sensing.

Analysis and control of information diffusion dictated by user interest in generalized networks.

The diffusion of useful information in generalized networks, such as those consisting of wireless physical substrates and social network overlays is very important for theoretical and practical applications. Contrary to previous works, we focus on the impact of user interest and its features (e.g., interest periodicity) on the dynamics and control of diffusion of useful information within such complex wireless-social systems. By considering the impact of temporal and topical variations of users interests, e.g., seasonal periodicity of interest in summer vacation advertisements which spread more effectively during Spring-Summer months, we develop an epidemic-based mathematical framework for modeling and analyzing such information dissemination processes and use three indicative operational scenarios to demonstrate the solutions and results that can be obtained by the corresponding differential equation-based formalism. We then develop an optimal control framework subject to the above information diffusion modeling that allows controlling the trade-off between information propagation efficiency and the associated cost, by considering and leveraging on the impact that user interests have on the diffusion processes. By analysis and extensive simulations, significant outcomes are obtained on the impact of each network layer and the associated interest parameters on the dynamics of useful information diffusion. Furthermore, several behavioral properties of the optimal control of the useful information diffusion with respect to the number of infected/informed nodes and the evolving user interest are shown through analysis and verified via simulations. Specifically, a key finding is that low interest-related diffusion can be aided by utilizing proper optimal controls. Our work in this paper paves the way towards this user-centered information diffusion framework.