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1.
Zh Mikrobiol Epidemiol Immunobiol ; (3): 66-71, 1979 Mar.
Artigo em Russo | MEDLINE | ID: mdl-571190

RESUMO

Gonadotropic activity of 106 series of immunoglobulin preparations obtained in the USSR and-the People's Republic of Bulgaria was studied. In difference from donor immunoglobulins, all the preparations of placental materials were contaminated with chorionic gonadotropin. Gonadotropin content in the immunoglobulins made of abortion serum was 2--7 times greater than in the preparations from the retoplacental serum and the placental extracts. The mean results of gonadotropin content in the immunoglobulins obtained by biological studies differed from those obtained from the investigations by immunological methods since the mentioned methods apparently characterized different properties of the hormonal molecule.


Assuntos
Aborto Espontâneo/imunologia , Doadores de Sangue , Gonadotropina Coriônica/imunologia , Imunoglobulinas/imunologia , Placenta/imunologia , Animais , Bulgária , Testes de Fixação de Complemento , Estabilidade de Medicamentos , Feminino , Testes de Inibição da Hemaglutinação , Humanos , Imunoglobulinas/isolamento & purificação , Camundongos , Gravidez , Radioimunoensaio , Ratos , Fatores de Tempo , U.R.S.S.
3.
Artigo em Russo | MEDLINE | ID: mdl-808058

RESUMO

With the aid of a modified Dubos and Schaedleder's method a determination was made on albino mice of the toxicity of 49 strains of meningococcus. The greatest toxicity was possessed by strains isolated from the cerebrospinal fluid of patients with cerebrospinal meningitis; standard strains were less toxic and strains isolated from healthy carriers were nontoxic. The living and the heated cultures of meningococci produced the same toxic action which was apparently associated with the thermostable antigens of the cell. The virulence studied in 24 strains of meningococcus on a model of 9-day chick embryos failed to correlate with the toxic properties of the strains.


Assuntos
Neisseria meningitidis/patogenicidade , Animais , Líquido Cefalorraquidiano/microbiologia , Embrião de Galinha , Humanos , Meningite Meningocócica/microbiologia , Camundongos , Neisseria meningitidis/isolamento & purificação , Virulência
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