RESUMO
BACKGROUND: Basic fibroblast growth factor (b-FGF) has recently been shown to have a positive effect on the treatment of postoperative mastoid cavity problem, but its ototoxicity has not been investigated. OBJECTIVE: To investigate the effect of b-FGF on the inner ear of guinea pigs. STUDY DESIGN AND SETTING: In groups A (n = 10) and B (n =11), b-FGF was applied into the left external auditory canal and the middle ear, respectively. The right ear served as a control. At 1 week after b-FGF administration, the endocochlear DC potential (EP) was measured, and morphology of the cochleae was examined by scanning electron microscopy. RESULTS: In group A, the EP values of experimental ears and controls were 90.0 +/- 8.4 (mV, mean +/- SD) and 89.4 +/- 4.3 (P > 0.05). In group B, the values were 86.5 +/- 11.4 and 87.5 +/- 6.1, respectively, (P > 0.05). Morphological findings showed no damage on the cochlear. CONCLUSION: Application of b-FGF to the external and middle ears does not seem to have an apparent risk of ototoxicity.
Assuntos
Orelha Interna/efeitos dos fármacos , Fator 2 de Crescimento de Fibroblastos/administração & dosagem , Administração Tópica , Animais , Contagem de Células , Cóclea/efeitos dos fármacos , Cóclea/fisiologia , Eletrofisiologia , Cobaias , Células Ciliadas Auditivas Internas/efeitos dos fármacos , Células Ciliadas Auditivas Externas/efeitos dos fármacos , Masculino , Microscopia Eletrônica de VarreduraRESUMO
OBJECTIVE: To clarify the three-dimensional anatomical features of the sphenoid sinus and its surrounding structures as are relevant to performing an endoscopic sphenoidotomy. METHODS: Various dimensions of 224 CT images of the sphenoid sinus and surrounding structures from 122 Japanese adult patients were measured using the multiplanar reconstruction technique. RESULTS: The mean distance from the nasal sill to the sphenoid ostium was nearly 66 mm, and that from the sphenoid ostium to the posterior wall of the sphenoid sinus was nearly 14 mm. The angles from the sphenoid ostium to both the carotid artery and the optic canal varied among the patients. The sphenoid ostium was located at almost the vertical midpoint of the anterior wall of the sphenoid sinus. CONCLUSION: The present study provides anatomical information about the sphenoid sinus and surrounding structures that is essential for avoiding complications in performing an endoscopic sphenoidotomy.
