RESUMO
BACKGROUND: Certain moisturizers can improve skin barrier function in atopic dermatitis. The effect of topical nicotinamide on atopic dry skin is unknown. We examined the effect of topical nicotinamide on atopic dry skin and compared the results with the effect of white petrolatum in a left-right comparison study. METHODS: Twenty-eight patients with atopic dermatitis, with symmetrical lesions of dry skin on both forearms, were enrolled, and were instructed to apply nicotinamide cream containing 2% nicotinamide on the left forearm and white petrolatum on the right forearm, twice daily over a 4- or 8-week treatment period. Transepidermal water loss and stratum corneum hydration were measured by instrumental devices. The amount of the stratum corneum exfoliated by tape stripping (desquamation index) was determined by an image analyzer. RESULTS: Nicotinamide significantly decreased transepidermal water loss, but white petrolatum did not show any significant effect. Both nicotinamide and white petrolatum increased stratum corneum hydration, but nicotinamide was significantly more effective than white petrolatum. The desquamation index was positively correlated with stratum corneum hydration at baseline and gradually increased in the nicotinamide group, but not in the white petrolatum group. CONCLUSIONS: Nicotinamide cream is a more effective moisturizer than white petrolatum on atopic dry skin, and may be used as a treatment adjunct in atopic dermatitis.
Assuntos
Dermatite Atópica/tratamento farmacológico , Niacinamida/administração & dosagem , Administração Tópica , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Perda Insensível de ÁguaAssuntos
Quitina Sintase/metabolismo , Sporothrix/enzimologia , Esporotricose/enzimologia , Idoso , Biópsia , Pré-Escolar , Quitina Sintase/genética , DNA Fúngico/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Dados de Sequência Molecular , Esporotricose/genética , Esporotricose/patologiaRESUMO
Plantar epidermoid cysts with human papillomavirus (HPV) infection are not rare in Japan. Most of them show the cytopathic effect of HPV type 60 - homogeneous intracytoplasmic inclusion bodies. Our case presented a plantar epidermoid cyst with vacuolation around the granular cell layer without any features of HPV type 60. In situ hybridization and polymerase chain reaction followed by DNA sequencing analysis revealed an association with HPV type 57.
Assuntos
Cisto Epidérmico/virologia , Dermatoses do Pé/virologia , Papillomaviridae/isolamento & purificação , Verrugas/virologia , Adulto , Cisto Epidérmico/patologia , Feminino , Dermatoses do Pé/patologia , Humanos , Hibridização In Situ , Análise de Sequência de DNA , Verrugas/patologiaAssuntos
Herpes Zoster/diagnóstico , Aciclovir/uso terapêutico , Seguimentos , Herpes Zoster/tratamento farmacológico , Humanos , Lactente , Extremidade Inferior , Masculino , Doenças Raras , Medição de Risco , Dermatopatias Virais/diagnóstico , Dermatopatias Virais/tratamento farmacológico , Resultado do TratamentoRESUMO
The clinical isolates from biopsy specimen human subcutaneous nodule developed orange-colored and wrinkled colonies on Sabouraud's dextrose agar at 24 C for 2 weeks. The isolates were aerobic and gram-positive. The bacteria were rod-shaped to coccoid and 1 x 5 microm in size. The assimilation tests revealed that the clinical isolate was identical to a reference strain of Nocardia veterana. A nucleotide sequence analysis of the 16S ribosomal DNA from the isolate and a reference strain of N. veterana showed 99.8% similarity. All data are consistent with the conclusion that the isolate in this human case of mycetoma is N. veterana.
