Exploring the intersection of Aspergillus fumigatus biofilms, infections, immune response and antifungal resistance.

Aspergillus fumigatus is an opportunistic pathogen that primarily affects the lungs and frequently elicits an allergic immune response in human hosts via inhalation of its airborne asexual spores (conidia). In immunocompromised individuals, the conidia of this fungus can germinate in the lung and result in severe systemic infections characterised by widespread tissue and organ damage. Conversely, in healthy hosts, the innate immune system is instrumental in eliminating the conidia and preventing disease progression. As with numerous other pathogenic fungi, A. fumigatus possesses a set of virulence factors that facilitate its infective mechanism and the circumvention of immune defences in susceptible hosts. The intrinsic capacity of A. fumigatus to form complex 3D-structured biofilms, both on biotic and abiotic surfaces, represents a key determinant of its evasion of the host immune system and resistance to antifungal drugs. This review delineates the pivotal role of A. fumigatus biofilm structure and function as a significant virulence factor in pathogenic infections, such as aspergilloma and invasive pulmonary aspergillosis (IPA). Additionally, we discuss the importance for the development of novel antifungal drugs as drug-resistant strains continue to evolve. Furthermore, co-infections of A. fumigatus with other nosocomial pathogens have a substantial impact on patient's health outcomes. In this context, we provide a brief overview of COVID-19-associated pulmonary aspergillosis (CAPA), a recently documented condition that has gained attention due to its associated high degree of severity.

Biochar-based fertilizers and their applications in plant growth promotion and protection.

Soil is an integral part of the ecosystem because it serves as a habitat for various microorganisms and lays the foundation for supporting plant growth and development. Therefore, factors such as increased anthropogenic activities hand by hand with other natural processes that harm the ecosystem may eventually lead to a decline in soil quality and fertility, hindering the growth of plants and soil microbial communities. Given the current global scenario of increasing human intervention, it is essential to find effective measures and reliable technologies to restore soil quality. Biochar is an emerging soil ameliorant employed for soil health restoration and is primarily generated through the anoxygenic pyrolysis of biomass. The biochar application in soil remediation may be beneficial due to biochar's unique physicochemical properties, including high carbon and metal fixation abilities. In addition, biochar possesses abilities to reduce the plant's environmental stress injuries. This review briefly overviewed the ingredients and mechanism of biochar productions. We then emphatically reviewed the advances in biochar applications in soil bioremediation, soil microflora growth stimulation, and the alleviation of various biotic and abiotic stresses in plants.