Decrease in activity of the serotoninergic system during mutagenesis.

We studied changes in the content of serotonin-modulated anticonsolidation protein in the liver of goldfishes and gobies caused by oil and industrial pollution. The concentration of serotonin-modulated anticonsolidation protein in fish liver increased after short-term exposure to oil-contaminated water (100 mg/liter), but decreased under long-term effect of industrial wastes. We hypothesize that serotonin plays a role in antimutagenic protection of the organism and maintains the differentiated state of mature cells.