1.
Org Biomol Chem
; 17(10): 2753-2758, 2019 03 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30785174
RESUMO
A system for the directed hydrogenation of nitrogen heterocycles is described in which hydrogen is delivered cis to a hydroxymethyl group by a rhodium catalyst with a simple phosphine ligand. The chemistry is applied to the synthesis of the hygric acid moiety of lincomycin and the pipecolic acid moiety of Argatroban. A series of control experiments indicate that the stereoselectivity is a result of a combination of both coordination and hydrogen bonding.
Assuntos
Aminoácidos/química , Aminoácidos/síntese química , Catálise , Técnicas de Química Sintética , Ligação de Hidrogênio , Hidrogenação , Ligantes , Lincomicina/química , Estereoisomerismo
2.
Top Curr Chem
; 342: 187-223, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23571858
RESUMO
The application of hydroformylation to the synthesis of natural products and natural product-like molecules is surveyed.