[Biochemical parameters in the diagnosis of nephrotoxicity of antineoplastic chemotherapy in children]. / Biokhimicheskie pokazateli v diagnostike nefrotoksichnosti protivoopukholevoi khimioterapii u detei.

The investigation was concerned with the role of enzymouria in the assessment of nephrotoxic effects identified in 19 children with malignant solid tumors who received cisplatin polychemotherapy in a dose of 100 mg/sq.m or iphosphamide in a dose 9 g/sq.m. Chemotherapy application was followed by a persistent hyperenzymouria involving significantly higher levels of N-acetyl-beta-D-hexosaminidase, beta-glutamyl transferase and alanine aminopeptidase in the urine, as compared with basal indices. Iphosphamide treatment showed significantly higher levels of enzymouria than those in cisplatin-treated patients. Higher than normal creatinine and urea concentrations were recorded only in 2 out of 9 patients receiving iphosphamide. Enzymouria evaluation was shown to be an effective method of nephrotoxic diagnosis.

[The possibilities for the long-term outpatient use of anthracyclines and platinum compounds]. / Vozmozhnosti dlitel'nogo primeneniia antratsiklinov i soedinenii platiny v ambulatornykh usloviiakh.

The results of chemotherapy administered to 47 cancer outpatients (a total of 222 cycles) were studied. Leukopenia, alopecia, nausea and vomiting, mostly moderate, were the most frequent side-effects. Outpatient chemotherapy proved as effective as that given under hospital conditions.