[Efficacy of baxtims in eliminating dysfunction of the liver monooxygenase system in exotoxinemia]. / Effektivnost' preparata bakstims v ustranenii narusheniia funktsii monooksigenaznoi sistemy pecheni pri ékzotoksemii.

The hepatoprotector activity of baxtims was studied with respect to hepatobiliary system pathologies. The tetrachloromethane and bulldok induced liver damage is accompanied by a significant decrease in activity of the monooxygenase system, which leads to violation of the detoxicant function and protein synthesis function of liver, followed by the development of engenous intoxication. Baxtims produced a pronounced hepatoprotector effect in the case of liver damage induced by toxicants of various chemical nature. The drug favors an increase in the concentration of cytochromes in liver microsomes, a decrease in the level of medium-molecular-mass peptides, and normalization of the protein synthesis. This hepatoprotector action justifies the drug administration in cases of exotoxinemia.

[Application of baxtims preparation in treatment of experimental diffuse purulent peritonitis]. / Primenenie preparata bakstims pri lechenii éksperimental'nogo razlitogo gnoinogo peritonita.

The proteins proteolysis increase as well as their biosynthesis disorder were observed in experimental diffuse purulent peritonitis, which was simulated in rats of Wistar line. Application of baxtims preparation for the abdominal cavity treatment during 14 days had promoted restoration of this process and the proteinic deficiency elimination as well.

[Application of carbon sorbents in the treatment of experimental peritonitis]. / Primenenie uglerodnykh sorbentov v lechenii éksperimental'nogo peritonita.

Comparative estimation of efficacy of sorpents SKN-1K, KAU, AU-L in experimental peritonitis was performed. Most favourable effect was observed after performance of hemosorption using AU-L. Sorpent KAU caused very pronounced detoxicational effect, but while its application additional correction of the glucose level is necessary, and that's why it is contraindicated in hypoglycemia. SKN absorbs toxic products least actively, but corrects the carbohydrate metabolism indexes better than KAU.

[Change in the concentration of nontoxic plasma components in the process of hemosorption in experimental acute liver failure]. / Izmenenie kontsentratsii netoksichnykh komponentov plazmy v protsesse gemosorbtsii pri éksperimental'noi ostroi pechenochnoi nedostatochnosti.

To study the hemosorption-induced changes in the plasma levels on nontoxic components, experiments were made on dogs with acute hepatic failure simulated by ligation of the common bile and vesicle tracts followed by administration of carbon tetrachloride into the common bile duct. Hemosorption was accomplished by the vein-vein variant by using KAU-type sorbent. Changes in lipid metabolism and the concentrations of biogenic amines were examined during and after a hemosorption session. The positive action of this procedure was found to appear as normalization of lipolysis whose activation occurred in acute hepatic failure, and as increases in the level of histamine and moderate-weight molecules.

[Changes of hemodynamics and microcirculation in ultraviolet blood irradiation for experimental peritonitis]. / Izmenenie gemodinamiki i mikrotsirkuliatsii pod vliianiem ultrafioletovogo oblucheniia krovi pri éksperimentalnom peritonite.

It was established that resulting form ultra-violet irradiation of the blood in peritonitis, the pulse increased, diastolic and systolic arterial pressure didn't decreased. The intensity of tissue blood flow increased, especially in the mesentery. This was caused by considerable increase in volumetric blood flow rate in the mesenteric artery.

[The modelling of diffuse peritonitis]. / Modelirovanie razlitogo peritonita.

Peritonitis is still an urgent problem and its solution is determined to a great measure by purposeful studies in the field of pathogenesis and treatment. The creation of adequate models of peritonitis acquires particular significance. Eighty-four animals (dogs) were used to create the model. It is shown in the work that a standard model of generalized peritonitis can be produced by two injections of a polymicrobial suspension consisting of the most commonly encountered peritoneal microbes E. coli and B. fragilis. The suspension is injected into different levels of the abdominal cavity. With this method of administration of the polymicrobial suspension the model was reproduced in 90% of cases. Thus, the developed model resembles human peritonitis in the clinical picture and the laboratory and morphological values.

[Side effects of hemosorption in the treatment of acute hepatic insufficiency]. / Pobochnye éffekty gemosorbtsii pri lechenii ostroi pechenochnoi nedostatochnosti.

The authors have established that in hemosorption with the use of the KAU type sorbent, the biologically active substances, which are the substrates of carbohydrate, lipid and protein metabolism were eliminated from the blood. After termination of a seánce of hemosorption, levels of all the substances studied were normalized. However, total protein content was not reestablished.

[The possibility of normalizing the microcirculation using hemosorption in experimental peritonitis]. / Vozmozhnost' normalizatsii mikrotsirkuliatsii pod vozdeistviem gemosorbtsii pri éksperimental'nom peritonite.

The goal of the present paper was a comparative study of microcirculation in the peritoneum, mesentery and omentum during the development of experimental peritonitis, as well as the investigation of possible correction of microcirculatory disturbances with the help of hemosorption. It has been established that different degree of microcirculatory disturbances in the tissues under study depended on the duration of peritonitis. Hemosorption recovered microcirculation to initial values, which indicated the reversibility of the disturbances.

[Effect of hemosorption and ultraviolet irradiation of blood on the blood levels of oligopeptides and biogenic amines in peritonitis]. / Vliianie gemosorbtsii i ul'trafioletovogo oblucheniia krovi na soderzhanie v nei oligopeptidov i biogennykh aminov pri peritonite.

Hemosorption permits more rapid and significant decrease in blood plasma concentration of oligopeptides. But at the same time, the decrease in concentration of a number of biogenic amines is noted. Under the influence of ultraviolet irradiation of the autologous blood, the reduction in manifestations of intoxication occurs slower, but norepinephrine production increases, contributing to improvement in the state of systemic hemodynamics and microcirculation.

[Possibilities of hemosorption using a fibrous sorbent in acute hepatic failure (experimental study)]. / Vozmozhnosti gemosorbtsii voloknistym sorbentom pri ostroi pechenochnoi nedostatochnosti (éksperimental'noe issledovanie).

The purpose of the experiment was study of the effect of hemosorption with the polymer sorbent PP-PAA (polypropylene-polyacrylic acid) on some hemodynamic values and level of metabolites in the blood of animals with acute hepatic failure. It was found that in perfusing blood through this sorbent there is practically no loss of total protein, the level of the studied metabolites in the blood reduces considerably, and the hepatic blood flow improves.

[Effects of benzonal on intracardiac hemodynamics in experimental myocardial infarct]. / Vliianie benzonala na vnutriserdechnuiu gemodinamiku pri éksperimental'nom infarkte miokarda.

Benzonal was tested for effects on the natural history of experimental myocardial infarction. Systemic and intracardiac hemodynamic parameters were studied in 35 Shinshilla rabbits. Benzonal was found to exert a positive action of myocardial diastolic relaxation and to be beneficial on the natural history of experimental myocardial infarction.

[Effect of hemosorption on the ultrastructure of hepatocytes in toxic liver damage]. / Vliianie gemosorbtsii na ul'trastrukturu gepatotsitov pri toksicheskom porazhenii pecheni.

Extracorporeal perfusion of toxic blood via carbonic sorbents is an effective method for correcting severe disturbances of hemostasis. Ultrastructural alterations in hepatic cells were studied in experimental toxic liver injury before and after hemosorption. It was established that after hemosorption the processes of intracellular regeneration were significantly activated in the liver parenchyma. The number of crysts in the mitochondria increased as did the electronic density of the matrix. At the same time the number of lysosomes rose as well. However, in persistent unresolved cholestasis, destructive alterations in the hepatic tissue progressed despite the performance of hemosorption.