1.
Bioorg Med Chem Lett
; 20(24): 7226-9, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21067919
RESUMO
A novel epoxide 2 was formed as the major product in the reaction of 2-bromo-3-methyl-1,4-naphthoquinone with 1,3-propanedithiol in the presence of triethylamine in 92% yield. Molecular oxygen is suggested to be the source of the added oxygen in 2, an oxidation product of its precursor 3. A strong base such as triethylamine is required to abstract the methyl hydrogen of 1,4-naphthoquinones, leading to the formation of 3 as well as 2.