Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 145
Filtrar
1.
Data Brief ; 4: 116-8, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26217773

RESUMO

The morphogenesis of the cerebral vesicles and ventricles was visualized in 3D movies using images derived from human embryo specimens between Carnegie stage 13 and 23 from the Kyoto Collection. These images were acquired with a magnetic resonance microscope equipped with a 2.35-T superconducting magnet. Three-dimensional images using the same scale demonstrated brain development and growth effectively. The non-uniform thickness of the brain tissue, which may indicate brain differentiation, was visualized with thickness-based surface color mapping. A closer view was obtained of the unique and complicated differentiation of the rhombencephalon, especially with regard to the internal view and thickening of the brain tissue. The present data contribute to a better understanding of brain and cerebral ventricle development.

2.
Neuroimage ; 115: 96-103, 2015 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-25934469

RESUMO

The three-dimensional dynamics and morphology of the human embryonic brain have not been previously analyzed using modern imaging techniques. The morphogenesis of the cerebral vesicles and ventricles was analyzed using images derived from human embryo specimens from the Kyoto Collection, which were acquired with a magnetic resonance microscope equipped with a 2.35-T superconducting magnet. A total of 101 embryos between Carnegie stages (CS) 13 and 23, without apparent morphological damage or torsion in the brain ventricles and axes, were studied. To estimate the uneven development of the cerebral vesicles, the volumes of the whole embryo and brain, prosencephalon, mesencephalon, and rhombencephalon with their respective ventricles were measured using image analyzing Amira™ software. The brain volume, excluding the ventricles (brain tissue), was 1.15 ± 0.43 mm(3) (mean ± SD) at CS13 and increased exponentially to 189.10 ± 36.91 mm(3) at CS23, a 164.4-fold increase, which is consistent with the observed morphological changes. The mean volume of the prosencephalon was 0.26 ± 0.15 mm(3) at CS13. The volume increased exponentially until CS23, when it reached 110.99 ± 27.58 mm(3). The mean volumes of the mesencephalon and rhombencephalon were 0.20 ± 0.07 mm(3) and 0.69 ± 0.23 mm(3) at CS13, respectively; the volumes reached 21.86 ± 3.30 mm(3) and 56.45 ± 7.64 mm(3) at CS23, respectively. The ratio of the cerebellum to the rhombencephalon was approximately 7.2% at CS20, and increased to 12.8% at CS23. The ratio of the volume of the cerebral vesicles to that of the whole embryo remained nearly constant between CS15 and CS23 (11.6-15.5%). The non-uniform thickness of the brain tissue during development, which may indicate the differentiation of the brain, was visualized with surface color mapping by thickness. At CS23, the basal regions of the prosencephalon and rhombencephalon were thicker than the corresponding dorsal regions. The brain was further studied by the serial digital subtraction of layers of tissue from both the external and internal surfaces to visualize the core region (COR) of the thickening brain tissue. The COR, associated with the development of nuclei, became apparent after CS16; this was particularly visible in the prosencephalon. The anatomical positions of the COR were mostly consistent with the formation of the basal ganglia, thalamus, and pyramidal tract. This was confirmed through comparisons with serial histological sections of the human embryonic brain. The approach used in this study may be suitable as a convenient alternative method for estimating the development and differentiation of the neural ganglia and tracts. These findings contribute to a better understanding of brain and cerebral ventricle development.


Assuntos
Encéfalo/anatomia & histologia , Encéfalo/embriologia , Angiografia Digital , Desenvolvimento Embrionário , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Imageamento Tridimensional , Imageamento por Ressonância Magnética , Vias Neurais/anatomia & histologia , Vias Neurais/embriologia , Neuroimagem , Gravidez
3.
Eur J Paediatr Dent ; 15(4): 360-6, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25517580

RESUMO

AIM: This study aimed to test the accuracy and precision of measurements of three-dimensional (3D) digital models from the pre-dentition period using a noncontact 3D measurement system (3D scanner) versus the gold standard method of direct measurements using a digital caliper on plaster models. MATERIALS AND METHODS: Ten pairs of plaster models were obtained from children during the predentition period. Linear measurements were performed using both methods. Three operators were trained in the use of both methods for this study. Measurements were performed with a minimum 2-week interval between measurements in a randomly chosen order. RESULTS: The mean difference between the measured values using the two methods was <0.2 mm for each measurement. There was no linearity in the measurements using pre-dentition digital models. An ANOVA Gage R&R analysis revealed that there was no significant operator difference (P < 0.307). The rate of variation of the 3D scanner over the total variation was 2.8%. The ICC was 0.982 (P< 0.001), suggesting excellent interoperator agreement. CONCLUSION: The results suggest that measurements of digital 3D pre-dentition models are highly accurate and precise, and also comparable to measurements using the gold standard method.


Assuntos
Cefalometria/estatística & dados numéricos , Processamento de Imagem Assistida por Computador/estatística & dados numéricos , Imageamento Tridimensional/estatística & dados numéricos , Modelos Dentários/estatística & dados numéricos , Viés , Sulfato de Cálcio/química , Calibragem , Humanos , Lactente , Mandíbula/anatomia & histologia , Maxila/anatomia & histologia , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Estudos Retrospectivos , Propriedades de Superfície
4.
Eur J Paediatr Dent ; 15(2): 137-42, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25102463

RESUMO

AIM: Recent advances in three-dimensional imaging have led to an increased interest in the application of computer-models in paediatric dentistry. However, in evidence-based paediatric dentistry the accuracy of new methods must be validated before they are introduced to clinical practice. We aimed to compare the accuracy of measurements of digital models obtained using a non-contact 3D measuring system, with direct measurements made on plaster models (gold standard) from children. MATERIALS AND METHODS: Twelve pairs of plaster models were obtained from children with deciduous dentition; tooth size, arch width, and arch length were examined. The same parts on each cast were measured twice with at least a 2-week interval between measurements with each method by four examiners. Linear mixed-effects model analyses were performed for comparison of values from the 2 different measurement methods. RESULTS: The average difference between the 2 methods in measured values, derived from the final model, was <0.2 mm. Random effect of examiners was always the smallest component of variance, and frequently negligible. STATISTICS: Intraclass correlation coefficients were typically >90%. CONCLUSION: These results suggest that primary dentition analysis of digital models has a high accuracy level, comparable to that of direct measurement of plaster models by digital calipers.


Assuntos
Modelos Anatômicos , Odontopediatria , Dente Decíduo , Criança , Pré-Escolar , Feminino , Humanos , Imageamento Tridimensional , Masculino
5.
Transpl Infect Dis ; 16(5): 853-8, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25040797

RESUMO

Human herpesvirus-6 (HHV-6) is a common pathogen among children, classically presenting with fever and rash that resolves without specific therapy. HHV-6 can be reactivated in the immunosuppressed patient. After bone marrow and solid organ transplantation, HHV-6 has been linked to various clinical syndromes, including undifferentiated febrile illness, encephalitis, myelitis, hepatitis, pneumonitis, and bone marrow suppression. However, HHV-6 encephalitis after pancreatic transplant has rarely been reported. Early diagnosis and treatment of HHV-6 encephalitis may be important for affected patients. We report the case of a 53-year-old pancreas-after-kidney transplant recipient who initially presented with high fever and confusion 3 weeks after operation. We managed to save the patient's life and preserve the pancreas graft function. We also review previously reported cases of HHV-6B encephalitis in solid organ transplant recipients.


Assuntos
Encefalite/virologia , Herpesvirus Humano 6 , Terapia de Imunossupressão/efeitos adversos , Transplante de Rim/efeitos adversos , Transplante de Pâncreas/efeitos adversos , Infecções por Roseolovirus/complicações , Antivirais/uso terapêutico , Encefalite/diagnóstico , Encefalite/tratamento farmacológico , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Infecções por Roseolovirus/diagnóstico , Infecções por Roseolovirus/tratamento farmacológico
6.
Transplant Proc ; 46(2): 640-3, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24656034

RESUMO

A 61-year-old Japanese woman, who had undergone hemodialysis because of chronic glomerulonephritis, received a living renal transplant from her ABO blood type-compatible spouse. HLA typing of A, B and DRB showed 3/6 mismatches. Complement-dependent cytotoxicity crossmatches, HLA antibody screening with the use of flow panel reactive antibody (PRA), and flow cytometry crossmatches (FCXM) were all negative. Tacrolimus, mycophenolate mofetil, methylprednisolone (MP), and basiliximab induction were used as the standard immunosuppressive therapy. After renal transplantation, her serum creatinine level favorably decreased, but urine output was not sufficiently obtained, contrary to our expectations. Doppler sonography revealed disappearance of diastolic arterial flow on postoperative day 2. The episode biopsy showed acute antibody-mediated rejection (AMR) based on the current Banff classification, although FCXM and flow PRA were still negative. To determine the cause of acute AMR, we expanded the HLA typing at high resolution levels to Cw, DQB1, and DPB1. Retrospective analysis of perioperative sera demonstrated the presence of low levels of donor-specific HLA IgG and moderate levels of IgM antibody against DQB1 before transplantation. There was an elevation of IgM antibody at the time of rejection, whereas IgG antibody showed no remarkable change. AMR was successfully treated with plasma exchange, low-dose intravenous immunoglobulin, high-dose intravenous MP pulse, and rituximab.


Assuntos
Autoanticorpos/imunologia , Rejeição de Enxerto/imunologia , Cadeias beta de HLA-DQ/imunologia , Neoplasias Renais/imunologia , Feminino , Citometria de Fluxo , Humanos , Imunossupressores/administração & dosagem , Pessoa de Meia-Idade
7.
Phys Rev Lett ; 110(10): 107204, 2013 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-23521291

RESUMO

We investigate the two-dimensional highly spin-polarized electron accumulation layers commonly appearing near the surface of n-type polar semiconductors BiTeX (X=I, Br, and Cl) by angular-resolved photoemission spectroscopy. Because of the polarity and the strong spin-orbit interaction built in the bulk atomic configurations, the quantized conduction-band subbands show giant Rashba-type spin splitting. The characteristic 2D confinement effect is clearly observed also in the valence bands down to the binding energy of 4 eV. The X-dependent Rashba spin-orbit coupling is directly estimated from the observed spin-split subbands, which roughly scales with the inverse of the band-gap size in BiTeX.

9.
Transplant Proc ; 44(1): 210-3, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22310616

RESUMO

ABO-incompatible (ABOi) renal transplantation has been increasing, but malignant tumor is a troubling complication of kidney transplantation due to potent immunosuppression. Few previous studies, however, have demonstrated that potent immunosuppression for ABOi living-donor renal transplantation (LDRT) is a risk factor for malignancy. In the present research, data on 252 LDRT patients ftom 2003 to 2008 were retrospectively analyzed to clarify whether ABOi LDRT was associated with malignancy. A potent immunosuppressive regimen for ABOiLDRT consisted of splenectomy, cyclophosphamide, and double-filtration plasmapheresis to minimize the risk of antibody-mediated rejection, in addition to conventional immunosuppresssants including calcineurin inhibitor, prednisolone, and anti-CD25 monoclonal antibody. A total of 11 incidences of malignancy were observed during a median follow-up of 48 months. The incidence rates in ABO-compatible (ABOc; n = 189) and ABOi (n = 63) LDRT groups were 4.2 % (8/189) and 4.8 % (3/63), respectively. Kaplan-Meier survival analysis showed no statistical difference in event-free survival for malignancy between ABOc and ABOiLDRT groups (log-rank P = .73). Multivariable Cox regression analyses identified no associations of malignancy with ABOi LDRT or any immunosuppressant use. In conclusion, our investigation suggested that potent immunosuppression with splenectomy and cyclophosphamide for ABOi LDRT may not be a risk factor for malignancy.


Assuntos
Sistema ABO de Grupos Sanguíneos/imunologia , Incompatibilidade de Grupos Sanguíneos/imunologia , Dessensibilização Imunológica/efeitos adversos , Histocompatibilidade , Transplante de Rim/imunologia , Neoplasias/imunologia , Adulto , Incompatibilidade de Grupos Sanguíneos/mortalidade , Distribuição de Qui-Quadrado , Dessensibilização Imunológica/mortalidade , Intervalo Livre de Doença , Quimioterapia Combinada , Feminino , Rejeição de Enxerto/imunologia , Rejeição de Enxerto/prevenção & controle , Sobrevivência de Enxerto , Humanos , Imunossupressores/efeitos adversos , Incidência , Japão , Estimativa de Kaplan-Meier , Transplante de Rim/efeitos adversos , Transplante de Rim/mortalidade , Doadores Vivos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Neoplasias/mortalidade , Plasmaferese/efeitos adversos , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Esplenectomia/efeitos adversos , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
10.
Transplant Proc ; 44(1): 281-3, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22310633

RESUMO

BACKGROUND: Elderly renal transplant candidates constitute one the fastest-growing populations among end-stage renal disease patients. Since the impacts of advanced recipient age have not yet been fully defined, we evaluated the clinical characteristics and outcomes of elderly renal transplant recipients. METHODS: Among 564 adult renal transplant recipients, at our center between 2000 and 2009, 64 were at least 60 years of age (Elderly group), and 500 were younger than 60 years (Young group) at the time of the procedure. We compared their clinical features and surgical management. RESULTS: There were significant differences in mean donor age (55.6 years vs. 53.2 years, P = .030) and gender mismatch (77.0% vs. 63.4%, P = .035). However, there were no significant differences between the two groups in patient and graft survivals (P = .177 and P = .365, respectively). Malignancy after transplantation was a significant risk factor upon univariate evaluation but only ABO incompatibility upon multivariate analysis of patient and graft survival. The main cause of graft loss among the Elderly group was death with a functioning graft due to heart failure. CONCLUSIONS: Renal transplantation is a feasible, safe option for the elderly and should be actively implemented. However, screening for cancer and heart disease should be mandatory to improve outcomes.


Assuntos
Falência Renal Crônica/cirurgia , Transplante de Rim , Sistema ABO de Grupos Sanguíneos/imunologia , Adolescente , Adulto , Fatores Etários , Idoso , Incompatibilidade de Grupos Sanguíneos/imunologia , Distribuição de Qui-Quadrado , Feminino , Rejeição de Enxerto/imunologia , Rejeição de Enxerto/prevenção & controle , Sobrevivência de Enxerto/efeitos dos fármacos , Insuficiência Cardíaca/etiologia , Histocompatibilidade , Humanos , Imunossupressores/uso terapêutico , Japão/epidemiologia , Estimativa de Kaplan-Meier , Falência Renal Crônica/mortalidade , Transplante de Rim/efeitos adversos , Transplante de Rim/imunologia , Transplante de Rim/mortalidade , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Neoplasias/etiologia , Seleção de Pacientes , Modelos de Riscos Proporcionais , Medição de Risco , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
11.
Br J Cancer ; 105(6): 833-41, 2011 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-21847129

RESUMO

BACKGROUND: On the basis of the microRNA (miRNA) expression signature of maxillary sinus squamous cell carcinoma (MSSCC), we found that miR-874 was significantly reduced in cancer cells. We focused on the functional significance of miR-874 in cancer cells and identification of miR-874-regulated novel cancer networks in MSSCC. METHODS: We used PCR-based methods to investigate the downregulated miRNAs in clinical specimens of MSSCC. Our signature analyses identified 23 miRNAs that were significantly reduced in cancer cells, such as miR-874, miR-133a, miR-375, miR-204, and miR-1. We focused on miR-874 as the most downregulated novel miRNA in our analysis. RESULTS: We found potential tumour suppressive functions such as inhibition of cancer cell proliferation and invasion. A molecular target search of miR-874 revealed that PPP1CA was directly regulated by miR-874. Overexpression of PPP1CA was observed in MSSCC clinical specimens. Silencing of the PPP1CA gene significantly inhibited cancer cell proliferation and invasion. CONCLUSION: The downregulation of miR-874 was a frequent event in MSSCC, which suggests that miR-874 functions as a tumour suppressive miRNA, directly regulating PPP1CA that has a potential role of an oncogene. The identification of novel miR-874-regulated cancer pathways could provide new insights into potential molecular mechanisms of MSSCC oncogenesis.


Assuntos
Carcinoma de Células Escamosas/genética , Seio Maxilar , MicroRNAs/metabolismo , Idoso , Idoso de 80 Anos ou mais , Proliferação de Células , Regulação para Baixo , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Proteína Fosfatase 1/genética
12.
Exp Clin Endocrinol Diabetes ; 118(5): 320-4, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20072962

RESUMO

AIMS: To compare the glycemic variability of insulin detemir and insulin glargine in type 1 and type 2 diabetic patients. METHODS: 15 type 1 and 14 type 2 diabetic patients receiving intensive insulin therapy with insulin glargine were enrolled. Before and after switching insulin glargine to insulin detemir, we assessed fasting glucose variability using the standard deviation (SD) and the coefficient of variance (CV) of self-monitored fasting blood sugar (FBS) levels. RESULTS: The SD and CV values were significantly decreased in type 1 diabetes after switching the therapy, though there was no significant difference in type 2 diabetes. The frequency of hypoglycemia was decreased in type 1 diabetes and there was no change in type 2 diabetes. The changes of the CV value also showed significant positive correlation with fasting serum CPR levels in all patients and total insulin dose in type 1 diabetes. The changes of frequency of hypoglycemia showed significant positive correlation with total and basal insulin dose adjusted for body weight in type 1 diabetes. CONCLUSION: The present study demonstrated lower within-subject variability of insulin detemir compared to insulin glargine, suggesting that the basal insulin replacement with insulin detemir may provide a useful therapeutic strategy for uncontrolled type 1 diabetes with high glucose variability.


Assuntos
Glicemia/metabolismo , Diabetes Mellitus Tipo 1/tratamento farmacológico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Insulina/análogos & derivados , Adulto , Idoso , Glicemia/efeitos dos fármacos , Pressão Sanguínea , Peptídeo C/sangue , Proteína C-Reativa/metabolismo , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 2/sangue , Relação Dose-Resposta a Droga , Jejum , Feminino , Hemoglobinas Glicadas/metabolismo , Humanos , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Insulina Detemir , Insulina Glargina , Insulina de Ação Prolongada , Insulina Regular de Porco , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes
13.
Appl Radiat Isot ; 68(1): 139-43, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19740672

RESUMO

A simple method was developed for determination of (99)Tc in low-level radioactive waste: Technetium-99 retained by a solid phase extraction disk was directly measured with imaging plates system. It was found that more than 97% of Tc were retained by the disk from a solution of pH 2 to 12, whereas depth profile of Tc in the disk, which greatly influences the counting efficiency, depended on solution pH. The present method was successfully applied to actual radioactive liquid waste samples arising from nuclear research facilities.


Assuntos
Resíduos Radioativos/análise , Tecnécio/análise , Poluentes Radioativos da Água/análise , Reatores Nucleares , Extração em Fase Sólida , Tecnécio/isolamento & purificação
14.
Kyobu Geka ; 61(5): 423-6, 2008 May.
Artigo em Japonês | MEDLINE | ID: mdl-18464493

RESUMO

A 30-year-old male who had suffered from the left hemopneumothorax due to the traffic accident 13 years before was admitted to our hospital suffering from abdominal pain. Computed tomography revealed the stomach was incarcerated through the left central tendon of the left diaphragm. He was diagnosed as delayed traumatic diaphragmatic hernia and emergency operation was performed via thoracic approach. Stomach and omentum, densely adhered to the lung and the chest wall, were strangulated in the left pleural cavity and hardly reducible. Stomach and omentum were reduced through the enlarged hernia and necrotized stomach was totally resected under the subsequent laparotomy. Hernia was closed directly via thoracic approach. A prompt diagnosis is necessary for a case highly suspicious of delayed traumatic diaphragmatic hernias presenting with strangulation.


Assuntos
Hérnia Diafragmática Traumática/complicações , Gastropatias/etiologia , Acidentes de Trânsito , Adulto , Emergências , Gastrectomia , Hérnia Diafragmática Traumática/diagnóstico , Hérnia Diafragmática Traumática/cirurgia , Humanos , Masculino , Necrose , Gastropatias/patologia , Gastropatias/cirurgia , Fatores de Tempo , Tomografia Computadorizada por Raios X
15.
Placenta ; 28(7): 676-87, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17182098

RESUMO

Although placental proteins play multiple roles in fetal and placental development and in the maintenance of pregnancy, many remain inadequately characterized. In the present study, we comprehensively analyzed these proteins by using a proteomic approach. Samples were denatured with guanidine hydrochloride, which was found to be superior to the commonly used urea for the present purpose, and subjected to 2-dimensional (2D) electrophoresis (2-DE) to obtain placental proteome maps. The identified protein spots (ca. 60% of the total) on the proteome maps included several pregnancy-related proteins (PRPs). Furthermore, a novel 2D immunoblotting (2-DI) analysis of molecules related to pre-eclampsia revealed three immunopositive spots that appeared to correspond to dynactin p-50, a protein related to cell turn-over. The rate of positivity for dynactin p-50-reactive antibodies was significantly (P=0.0024) higher in 26 pre-eclamptic women than in 58 normally pregnant women. These results indicate that dynactin p-50 may be involved in the pathophysiology of pre-eclampsia.


Assuntos
Proteínas Associadas aos Microtúbulos/análise , Placenta/química , Pré-Eclâmpsia/metabolismo , Gravidez/metabolismo , Proteoma/análise , Adulto , Anticorpos/imunologia , Complexo Dinactina , Eletroforese em Gel Bidimensional , Feminino , Guanidina/química , Humanos , Proteínas Associadas aos Microtúbulos/sangue , Placenta/metabolismo , Desnaturação Proteica
16.
Neurology ; 64(8): 1452-4, 2005 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-15851744

RESUMO

There is controversy regarding the initial pathology of tabes dorsalis. In a patient with early tabes dorsalis, tibial nerve somatosensory evoked potentials elicited normal P15, a delayed traveling peak in the lumbar bipolar leads, and absent subsequent components. Based on the comparison with normative data and stimulation at different intensities, the authors conclude that only the slower conducting antidromic motor volleys are preserved, whereas the dorsal root is damaged at its distal end.


Assuntos
Potenciais Somatossensoriais Evocados , Transtornos de Sensação/fisiopatologia , Raízes Nervosas Espinhais/fisiopatologia , Tabes Dorsal/diagnóstico , Tabes Dorsal/fisiopatologia , Nervo Tibial/fisiopatologia , Adulto , Progressão da Doença , Estimulação Elétrica , Eletrodiagnóstico , Potenciais Evocados , Potenciais Somatossensoriais Evocados/fisiologia , Transtornos Neurológicos da Marcha/diagnóstico , Transtornos Neurológicos da Marcha/etiologia , Transtornos Neurológicos da Marcha/fisiopatologia , Gânglios Espinais/fisiopatologia , Humanos , Masculino , Condução Nervosa/fisiologia , Neuralgia/etiologia , Neuralgia/patologia , Neuralgia/fisiopatologia , Neurônios Aferentes/fisiologia , Penicilina G/uso terapêutico , Tempo de Reação/fisiologia , Recuperação de Função Fisiológica , Reflexo Anormal/fisiologia , Transtornos de Sensação/diagnóstico , Transtornos de Sensação/etiologia , Distúrbios Somatossensoriais/diagnóstico , Distúrbios Somatossensoriais/etiologia , Distúrbios Somatossensoriais/fisiopatologia , Tabes Dorsal/tratamento farmacológico , Resultado do Tratamento
17.
J Dent Res ; 84(2): 133-7, 2005 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-15668329

RESUMO

Patients with open bite often show a weak occlusal force and temporomandibular disorders (TMDs). If these are the main cause of open bite, it may be hypothesized that both pre-pubertal and adult open-bite patients would show a weak occlusal force and abnormal condylar motion. The purpose of this study was to test this hypothesis. Test group subjects consisted of 13 consecutive pre-pubertal and 13 adult patients with anterior open bite. They were compared with age-matched normal subjects. The adult open-bite group showed a weaker occlusal force and a shorter range of condylar motion compared with the control subjects. In the pre-pubertal subjects, however, there were no significant differences in the occlusal force and range of condylar motion between the open-bite and control groups. Therefore, these results suggest that a weak occlusal force or TMDs may not be the main cause of open bite.


Assuntos
Força de Mordida , Mordida Aberta/fisiopatologia , Amplitude de Movimento Articular/fisiologia , Transtornos da Articulação Temporomandibular/fisiopatologia , Articulação Temporomandibular/fisiologia , Adolescente , Adulto , Cefalometria , Criança , Feminino , Humanos , Masculino , Côndilo Mandibular/fisiologia , Análise por Pareamento , Mordida Aberta/complicações , Articulação Temporomandibular/fisiopatologia , Transtornos da Articulação Temporomandibular/etiologia
18.
Eur J Cardiothorac Surg ; 26(2): 348-50, 2004 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15296895

RESUMO

OBJECTIVE: Because residual dissection often exists even after the repair of a type A dissection, we evaluated coagulation conditions, cytokine levels, and adhesion molecule levels in mid-term follow up after repair of type A dissections. METHODS: Thrombin-antithrombin III complex (TAT), D-dimer, soluble interleukin-2 receptor (sIL-2R), soluble intercellular adhesion molecule (sICAM)-1, and type III procollagen peptide (PIIIP) were measured in 12 patients (mean age=63 years) following the repair of a type A aortic dissection at 6-82 months after repair (median=33 months). RESULTS: In the chronic phase, TAT and D-dimer were significantly higher in patients following the repair of a type A dissection compared to healthy controls (TAT; 12+/-8 vs. 2.5+/-1.2 ng/ml, P = 0.0001, D-dimer; 779+/-1384 vs. 104+/-46 U/ml, P = 0.0001). Cytokine was significantly higher in the affected patients (sIL-2R; 556+/-205 vs. 398+/-132 U/ml, P = 0.003, sICAM-1; 255+/-131 vs. 211+/-48 ng/ml, P = 0.136). Collagen turnover (PIIIP) showed a significantly higher value in the affected patients (0.80+/-0.32, vs. 0.58+/-0.13 U/ml, P = 0.002). sIL-2R, sICAM-1 and PIIIP showed a negative correlation with the follow-up period (sIL-2R; r = -0.733, P = 0.0067, sICAM-1; r = -0.61, P = 0.035, PIIIP; r = -0.692, P = 0.0126). We found a positive correlation between aortic size and TAT (r = 0.644, P = 0.0238, n = 12) as well as with D-dimer (r = -0.7831, P = 0.0106, n = 12) and TAT showed significantly higher values in the residual dissection group compared to those without residual dissection (16.6+/-7.9 vs. 7.45+/-4.75 ng/ml, P = 0.035). CONCLUSION: Hypercoagulation conditions continued even after repair. Both TAT and D-dimer would be good indices for following up patients having repaired aortic dissections. Furthermore, cytokine, adhesion molecules, and collagen turnover would return to a stable state unless impairment and expansion of the vessel wall occurred.


Assuntos
Aneurisma Aórtico/cirurgia , Dissecção Aórtica/cirurgia , Coagulação Sanguínea/fisiologia , Molécula 1 de Adesão Intercelular/sangue , Receptores de Interleucina-2/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Dissecção Aórtica/sangue , Antifibrinolíticos/sangue , Antitrombina III , Aneurisma Aórtico/sangue , Colágeno Tipo III/sangue , Produtos de Degradação da Fibrina e do Fibrinogênio/análise , Humanos , Pessoa de Meia-Idade , Peptídeo Hidrolases/sangue , Pró-Colágeno , Solubilidade
19.
Transplant Proc ; 36(2 Suppl): 461S-464S, 2004 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15041388

RESUMO

We investigated the clinical benefits of cyclosporine microemulsion preconcentrate (CyA-MEPC; Neoral) in 16 de novo renal transplant recipients. The dose of CyA-MEPC was managed from AUC(0-4h), with serial target values of AUC(0-4h) at 5000-->4000-->3000-->2000 ng. hr/mL. The frequency of acute rejection episodes was 25%. The decreased renal function reached a low value of 12.5%, and creatinine was stable. Therefore, setting the target AUC(0-4h) value in the early phase at 5000 ng.hr/mL is an effective strategy to prevent acute rejection episodes. The single dose of Neoral given immediately after the renal transplant was 6 mg/kg (making a daily dose of 12 mg/kg). Thereafter, the dose-normalized AUC(0-4h) was set at a constant value to 4 weeks posttransplant. At week 4, the single dose was decreased to 4 mg/kg twice daily (a daily dose of 8 mg/kg). From these studies a daily dose of 12 mg/kg is suggested to be the appropriate amount for the first dose immediately after transplant. The renal biopsy performed at 6 months posttransplant showed neither cyclosporine-induced renal impairments, nor findings of chronic rejection, suggesting that 2000 ng.hr/mL is an appropriate target AUC(0-4h) value in the maintenance phase. These results suggest that it is possible to set the target value of C2 monitoring in the maintenance phase to a value slightly lower than that proposed from other studies.


Assuntos
Ciclosporina/farmacocinética , Ciclosporina/uso terapêutico , Absorção Intestinal/fisiologia , Transplante de Rim/imunologia , Ácido Micofenólico/análogos & derivados , Adulto , Área Sob a Curva , Ciclosporina/administração & dosagem , Ciclosporina/sangue , Quimioterapia Combinada , Feminino , Rejeição de Enxerto/epidemiologia , Rejeição de Enxerto/prevenção & controle , Humanos , Imunossupressores/administração & dosagem , Imunossupressores/farmacocinética , Imunossupressores/uso terapêutico , Transplante de Rim/fisiologia , Masculino , Ácido Micofenólico/uso terapêutico , Período Pós-Operatório , Fatores de Tempo
20.
Epidemiol Infect ; 132(1): 145-9, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-14979600

RESUMO

The number of patients with severe invasive group-G streptococcal (Streptococcus dysgalactiae subsp. equisimilis) infections has been increasing in Japan. The emm genotypes and SmaI-digested pulsed-field gel electrophoresis DNA profiles were variable among the strains isolated, suggesting there has not been clonal expansion of a specific subpopulation of strains. However, all strains carried scpA, ska, slo and sag genes, some of which may be involved in the pathogenesis of the disease.


Assuntos
Adesinas Bacterianas , Infecções Estreptocócicas/epidemiologia , Infecções Estreptocócicas/microbiologia , Streptococcus , Idoso , Idoso de 80 Anos ou mais , Impressões Digitais de DNA/métodos , DNA Bacteriano , Eletroforese em Gel de Campo Pulsado , Endopeptidases/genética , Feminino , Variação Genética/genética , Genótipo , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Epidemiologia Molecular , Reação em Cadeia da Polimerase/métodos , Vigilância da População , Estudos Soroepidemiológicos , Sorotipagem , Índice de Gravidade de Doença , Infecções Estreptocócicas/diagnóstico , Streptococcus/classificação , Streptococcus/genética , Streptococcus/patogenicidade , Virulência/genética
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...