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1.
J Trauma Stress ; 36(1): 205-217, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36514902

RESUMO

Cognitive processing therapy (CPT) is one of the most widely tested evidence-based treatments for posttraumatic stress disorder (PTSD). However, most studies on CPT have been conducted in Western cultural settings. This open-label, single-arm trial investigated the feasibility, acceptability, and preliminary efficacy of CPT for treating Japanese patients with PTSD. A total of 25 outpatients underwent 12 CPT sessions. The primary outcome was the assessment of PTSD symptoms using the Clinician-Administered PTSD Scale for DSM-IV (CAPS-IV); secondary outcomes included the assessment of subjective PTSD severity, depressive and anxiety symptoms, trauma-related cognitions, and subjective quality of life. All outcomes were evaluated at pretreatment (i.e., baseline), posttreatment, and 6- and 12-month follow-ups. On average, participants attended 13 sessions of CPT (SD = 1.38), with a completion rate of 96.0%. One serious adverse event (hospitalization) occurred. Significant within-subjects standardized mean differences in CAPS-IV scores were found from baseline to treatment completion, g = -2.28, 95% CI [-3.00, -1.56]; 6-month follow-up, g = -2.95, 95% CI [-3.79, -2.12]; and 12-month follow-up, g = -2.15, 95% CI [-2.89, -1.41]. Moderate-to-large effects, gs = -0.77 to -2.45, were found on secondary outcomes. These findings support the feasibility, acceptability, and preliminary efficacy of CPT in a Japanese clinical setting.


Assuntos
Terapia Cognitivo-Comportamental , Transtornos de Estresse Pós-Traumáticos , Humanos , População do Leste Asiático , Estudos de Viabilidade , Qualidade de Vida , Transtornos de Estresse Pós-Traumáticos/terapia , Resultado do Tratamento
2.
JMIR Mhealth Uhealth ; 10(5): e34154, 2022 05 23.
Artigo em Inglês | MEDLINE | ID: mdl-35604760

RESUMO

BACKGROUND: Adolescent health promotion is important in preventing risk behaviors and improving mental health. Health promotion during adolescence has been shown to contribute to the prevention of late onset of the mental health disease. However, scalable interventions have not been established yet. OBJECTIVE: This study was designed to test the efficacy of two adolescent health promotion interventions: a well-care visit (WCV) with a risk assessment interview and counseling and self-monitoring with a smartphone cognitive behavioral therapy (CBT) app. Our hypothesis was that participants who had received both WCV and the CBT app would have better outcomes than those who had received only WCV or those who had not received any intervention. We conducted a prospective multi-institutional randomized controlled trial. METHODS: Participants were 217 adolescents aged 13-18 years. They were randomly divided into two intervention groups (WCV group and WCV with CBT app group) and a nonintervention group. WCV comprised a standardized physical examination along with a structured interview and counseling for youth risk assessment, which was designed with reference to the Guideline for Health Supervision of Adolescents of Bright Futures. A smartphone-based CBT program was developed based on the CBT approach. The CBT app comprised a 1-week psychoeducation component and a 1-week self-monitoring component. During the CBT program, participants created several self-monitoring sheets based on the CBT model with five window panels: event, thoughts, feelings, body response, and actions. The primary outcome was the change in scores for depressive symptoms. Secondary outcomes included changes in scores for self-esteem, quality of life, self-monitoring, and an adolescent health promotion scale. These outcomes were evaluated at baseline and at 1, 2, and 4 months after baseline. The exploratory outcome was the presence of suicidal ideation during the observation period. Intervention effects were estimated using mixed effect models. RESULTS: In total, 94% (204/217) of the participants completed the 4-month evaluation. Both intervention groups showed a significant effect in the form of reduced scores for depressive symptoms at 1 month in high school students; however, these effects were not observed at 2 and 4 months. The intervention effect was significantly more predominant in those scoring above cutoff for depressive symptoms. There was significantly less suicidal ideation in the intervention groups. As for secondary outcomes, there was significant increase in health promotion scale scores at the 4-month follow-up among junior high school students in the WCV group. Moreover, the CBT app was significantly effective in terms of obtaining self-monitoring skills and reducing depressive symptoms. CONCLUSIONS: Although adolescent health promotion interventions may have short-term benefits, the frequency of WCV and further revision of the CBT app should be considered to evaluate long-term effectiveness. TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trials Registry UMIN 000036343; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000041246.


Assuntos
Saúde do Adolescente , Terapia Cognitivo-Comportamental , Depressão , Promoção da Saúde , Aplicativos Móveis , Adolescente , Terapia Cognitivo-Comportamental/métodos , Depressão/diagnóstico , Depressão/terapia , Promoção da Saúde/métodos , Humanos , Visita a Consultório Médico , Estudos Prospectivos , Qualidade de Vida , Medição de Risco , Smartphone
3.
Eur J Psychotraumatol ; 11(1): 1753938, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32595913

RESUMO

Background: The diagnostic criteria for posttraumatic stress disorder (PTSD) differ between DSM-5 and ICD-11, which may affect the estimation of prevalence. Objective: To investigate the concordance of ICD-11 and DSM-5, as compared to ICD-10 and DSM-IV, regarding PTSD caseness among Japanese people who had experienced different potentially traumatic events. In addition, we estimated the comorbidity with major depressive disorder and generalized anxiety disorder according to these four diagnostic manuals. Method: A web-based survey (n = 6,180) was conducted from November 2016 to March 2017. Participants completed the PTSD Checklist for DSM-5, and other standardized measures of PTSD, depression, and anxiety. Results: The prevalence of PTSD caseness according to ICD-11 was significantly lower as compared to DSM-IV, DSM-5, and ICD-10. Cohen's kappa between DSM-5 and ICD-11 was 0.79, indicating substantial agreement. Comorbidity with depression was significantly higher in unique DSM-5 cases than in unique ICD-11 cases. Unique DSM-5 PTSD cases were significantly stronger functionally impaired than unique ICD-11 PTSD cases. Conclusions: Although requiring fewer items, the ICD-11 showed substantial agreement with DSM-5 regarding PTSD caseness. The lower comorbidity rates in unique cases may support the concept of the ICD-11 which intends to reduce comorbidity by identifying the core elements of PTSD.


Antecedentes: Los criterios diagnósticos para trastorno de estrés postraumático (TEPT) difieren entre el DSM-5 y la CIE-11, lo cual puede afectar la estimación de prevalencia.Objetivo: Investigar la concordancia de la CIE-11 y DSM-5, comparada con la CIE-10 y DSM-IV, en relación a la casuística de TEPT entre la población japonesa que ha experimentado diferentes eventos potencialmente traumáticos. Además, estimamos la comorbilidad con el trastorno depresivo mayor y el trastorno de ansiedad generalizada según estos cuatro manuales diagnósticos.Método: Se condujo una encuesta basada en la web (n= 6.180) entre Noviembre del 2016 y Marzo del 2017. Los participantes completaron la Lista de verificación de TEPT según el DSM-5, y otras mediciones estandarizadas para TEPT, depresión y ansiedad.Resultados: La prevalencia de casuística de TEPT según la CIE-11 fue significativamente menor comparada con el DSM-IV, DSM-5 y CIE-10. La kappa de Cohen entre el DSM-5 y CIE-11 fue de 0.79, lo que indica un acuerdo sustancial. La comorbilidad con depresión fue significativamente mayor en casos únicos del DSM-5 que en casos únicos de la CIE-11. Los casos únicos de TEPT según el DSM-5 tuvieron una discapacidad funcional significativamente más fuerte que los casos únicos de TEPT según la CIE-11.Conclusiones: Aunque la CIE-11 requiere menos ítems, mostró un acuerdo sustancial con el DSM-5 en relación a la casuística de TEPT. Las tasas más bajas de comorbilidad en los casos únicos pueden respaldar el concepto de la CIE-11 que tiene la intención de reducir la comorbilidad mediante la identificación de los elementos centrales del TEPT.

4.
BMJ Open ; 7(6): e014292, 2017 06 30.
Artigo em Inglês | MEDLINE | ID: mdl-28667201

RESUMO

INTRODUCTION: Cognitive processing therapy (CPT) is widely regarded as a safe and effective first-line treatment for individuals with post-traumatic stress disorder (PTSD); however, no comparative studies have been conducted to examine the treatment outcomes in an Asian population. The aim of the present trial is to investigate the efficacy of CPT (individual format) as a treatment for PTSD in a population of Japanese patients. METHODS AND ANALYSIS: A 16-week, single-centre, assessor-masked, randomised, parallel-group superiority trial has been designed to compare the efficacy of CPT in conjunction with treatment as usual (mostly pharmacotherapy and clinical monitoring) versus treatment as usual alone. The Clinician-Administered PTSD Scale for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) will be our primary outcome measure of the post-traumatic stress symptoms at 17 weeks, whereas the PTSD Checklist for DSM-5 and determination of the operationally defined responder status will be used to assess the secondary outcomes. An estimated sample size of 29 participants in each group will be required to detect an expected effect size of 1.4 (95% CI 0.85 to 1.95). ETHICS AND DISSEMINATION: The institutional review board at the National Center of Neurology and Psychiatry in Japan approved this study. The results of this clinical trial will be presented at conferences and disseminated through publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: UMIN000021670 (registered on 1 April 2016).


Assuntos
Terapia Cognitivo-Comportamental/métodos , Projetos de Pesquisa , Transtornos de Estresse Pós-Traumáticos/terapia , Estudos de Casos e Controles , Humanos , Japão , Qualidade de Vida , Autorrelato , Resultado do Tratamento
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