Assuntos
Melanoma , Neoplasias Cutâneas , Humanos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , População do Leste Asiático , Ipilimumab/uso terapêutico , Melanoma/tratamento farmacológico , Melanoma/etiologia , Nivolumabe/uso terapêutico , Estudos Retrospectivos , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/etiologiaAssuntos
Povo Asiático , Colite Ulcerativa/etiologia , Doença de Crohn/etiologia , Diverticulose Cólica/etiologia , Doenças do Colo Sigmoide/etiologia , Idoso , Idoso de 80 Anos ou mais , Colite Ulcerativa/diagnóstico , Colite Ulcerativa/dietoterapia , Doença de Crohn/diagnóstico , Doença de Crohn/dietoterapia , Dieta/efeitos adversos , Diverticulose Cólica/diagnóstico , Diverticulose Cólica/dietoterapia , Feminino , Humanos , Masculino , Doenças do Colo Sigmoide/diagnóstico , Doenças do Colo Sigmoide/dietoterapiaRESUMO
Here we report two cases of primary skeletal muscle lymphoma. The first patient was an 82-year-old man. On April 2004, he was referred to our hospital because of swelling of the right upper arm. Magnetic resonance imaging (MRI) showed an area which was isointense on T1 and hyperintense on T2-weighted imaging compared with normal skeletal muscle. The size of the tumor was 5 x 7 x 13 cm. Following pathological, flow cytometric and genetic analyses of the specimen, we diagnosed the tumor as a non-Hodgkin lymphoma of the T-cell rich diffuse large B-cell type. The second patient was an 87-year-old man. He was admitted to our hospital on July 2004, under the chief complaint of swelling of the right thigh. MRI revealed a giant tumor mass of the right thigh which was isointense on T1 and hyperintense on T2 imaging. The patient was diagnosed by open biopsy as having diffuse large B-cell lymphoma. We could find only 62 cases of primary skeletal muscle lymphoma through a MEDLINE search. We report on our two cases with a review of the literature.
Assuntos
Linfoma de Células B/diagnóstico , Linfoma Difuso de Grandes Células B/diagnóstico , Linfoma não Hodgkin/diagnóstico , Linfoma de Células T/diagnóstico , Neoplasias Musculares/diagnóstico , Músculo Esquelético , Idoso de 80 Anos ou mais , Evolução Fatal , Humanos , Linfoma de Células B/patologia , Linfoma de Células B/terapia , Linfoma Difuso de Grandes Células B/patologia , Linfoma Difuso de Grandes Células B/terapia , Linfoma não Hodgkin/patologia , Linfoma não Hodgkin/terapia , Linfoma de Células T/patologia , Linfoma de Células T/terapia , Imageamento por Ressonância Magnética , Masculino , Neoplasias Musculares/patologia , Neoplasias Musculares/terapia , Resultado do TratamentoAssuntos
Anemia Ferropriva/metabolismo , Anemia/metabolismo , Ferro/metabolismo , Anemia/etiologia , Anemia Ferropriva/genética , Animais , Peptídeos Catiônicos Antimicrobianos/fisiologia , Proteínas de Transporte de Cátions/genética , Proteínas de Transporte de Cátions/fisiologia , Doença Crônica , Hepatite/complicações , Hepcidinas , Humanos , Inflamação/complicações , Proteínas de Ligação ao Ferro/genética , Proteínas de Ligação ao Ferro/fisiologia , Neoplasias Hepáticas/complicações , Sistema Fagocitário Mononuclear/metabolismo , Receptores da Transferrina/fisiologia , Transferrina/genética , Transferrina/fisiologiaRESUMO
We measured paclitaxel (PTX) concentrations in blood and ascites in a patient with advanced gastric cancer treated with weekly paclitaxel (80 mg/m2). After 180 minutes from infusion of PTX, the concentration of PTX in ascites was 13 ng/ml, which was more than the reported cytotoxic dose of PTX (8.5 ng/ml). The concentration of PTX in ascites was retained, and rose rather slowly during a 24-hour period. The patient died soon after the measurement, meaning this measurement was taken at a time when the antitumor effect was ineffective and under poor general conditions. The result suggested, however, that the desired concentration of PTX in ascites can be obtained with a smaller dose of PTX in a regimen of weekly PTX.
